ACVR1B | GeneID:91 | Homo sapiens

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 91 Official Symbol ACVR1B
Locus N/A Gene Type protein-coding
Full Name activin A receptor, type IB
Description activin A receptor, type IB
Chromosome 12q13
Also Known As activin A receptor, type II-like kinase 4; activin receptor-like kinase 4; serine(threonine) protein kinase receptor R2
Summary Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed. [provided by RefSeq]

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 20906

ID Symbol Protein Species
GeneID:91 ACVR1B NP_004293.1 Homo sapiens
GeneID:11479 Acvr1b NP_031421.1 Mus musculus
GeneID:29381 Acvr1b NP_954700.1 Rattus norvegicus
GeneID:30183 acvr1b NP_571065.1 Danio rerio
GeneID:451911 ACVR1B XP_001145219.1 Pan troglodytes
GeneID:486537 ACVR1B XP_543663.2 Canis lupus familiaris
GeneID:539315 ACVR1B XP_586402.3 Bos taurus
GeneID:559222 LOC559222 XP_687633.2 Danio rerio
GeneID:768878 ACVR1B XP_001231301.1 Gallus gallus


[ - ] Monoclonal and Polyclonal Antibodies

No. Provider Product No. Description
1 abcam ab37813 Activin A Receptor Type IB antibody (ab37813); Rabbit polyclonal to Activin A Receptor Type IB
2 abcam ab54953 Activin A Receptor Type IB antibody (ab54953); Mouse monoclonal to Activin A Receptor Type IB
3 abcam ab64813 Activin A Receptor Type IB antibody (ab64813); Rabbit polyclonal to Activin A Receptor Type IB
4 abcam ab10594 Activin A Receptor Type IB antibody (ab10594); Goat polyclonal to Activin A Receptor Type IB
5 abgent AP7801a ACVR1B Antibody (N-term); Purified Rabbit Polyclonal Antibody (Pab)
6 abgent AP7801b ACVR1B Antibody (Center I149); Purified Rabbit Polyclonal Antibody (Pab)
7 abgent AP7801c ACVR1B Antibody (Center); Purified Rabbit Polyclonal Antibody (Pab)
8 abnova H00000091-M08 ACVR1B monoclonal antibody (M08), clone 6G11; Mouse monoclonal antibody raised against a partial recombinant ACVR1B.
9 abnova H00000091-M06 ACVR1B monoclonal antibody (M06), clone 2E12; Mouse monoclonal antibody raised against a partial recombinant ACVR1B.
10 abnova H00000091-M02 ACVR1B monoclonal antibody (M02), clone 6D3; Mouse monoclonal antibody raised against a partial recombinant ACVR1B.
11 abnova H00000091-M01 ACVR1B monoclonal antibody (M01), clone 2D4; Mouse monoclonal antibody raised against a partial recombinant ACVR1B.
12 abnova H00000091-M09 ACVR1B monoclonal antibody (M09), clone 1C1; Mouse monoclonal antibody raised against a partial recombinant ACVR1B.
13 acris AP14598PU-N Activin receptor type 1B (ACVR1B) (Center); antibody Ab
14 acris AP14597PU-N Activin receptor type 1B (ACVR1B) (Center); antibody Ab
15 acris AP14596PU-N Activin receptor type 1B (ACVR1B) (N-term); antibody Ab
16 acris AP06686PU-N Activin receptor type 1B (ACVR1B); antibody Ab
17 scbt ACVR1B ACVR1B Antibody / ACVR1B Antibodies;
18 sigma A2455 Anti-Activin Receptor IB antibody produced in goat ;

Exon, Intron and UTRs

Exon, Intron and UTRs of ACVR1B Gene Transcript Isoforms

CpG near TSS

CpG dinucleotides near Transcription Start Site of ACVR1B Gene

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0009986 Component cell surface
GO:0005887 Component integral to plasma membrane
GO:0016020 Component membrane
GO:0048185 Function activin binding
GO:0016361 Function activin receptor activity, type I
GO:0005524 Function ATP binding
GO:0019838 Function growth factor binding
GO:0000287 Function magnesium ion binding
GO:0030145 Function manganese ion binding
GO:0000166 Function nucleotide binding
GO:0004674 Function protein serine/threonine kinase activity
GO:0004872 Function receptor activity
GO:0046332 Function SMAD binding
GO:0016740 Function transferase activity
GO:0043130 Function ubiquitin binding
GO:0031625 Function ubiquitin protein ligase binding
GO:0009790 Process embryonic development
GO:0000082 Process G1/S transition of mitotic cell cycle
GO:0001942 Process hair follicle development
GO:0006917 Process induction of apoptosis
GO:0001701 Process in utero embryonic development
GO:0030308 Process negative regulation of cell growth
GO:0018107 Process peptidyl-threonine phosphorylation
GO:0032927 Process positive regulation of activin receptor signaling pathway
GO:0045648 Process positive regulation of erythrocyte differentiation
GO:0046777 Process protein amino acid autophosphorylation
GO:0045449 Process regulation of transcription
GO:0007165 Process signal transduction
GO:0007178 Process transmembrane receptor protein serine/threonine kinase signaling pathway

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_004302  UCSC Browser NP_004293
2 NM_020327  UCSC Browser NP_064732
3 NM_020328  UCSC Browser NP_064733

MicroRNA and Targets

[ - ] MicroRNA Sequences and Transcript Targets from miRBase at Sanger

RNA Target miRNA # mat miRNA Mature miRNA Sequence
ENST00000257963 MI0005512 mmu-miR-467c UAAGUGCGUGCAUGUAUAUGUG
ENST00000257963 MI0005513 mmu-miR-467d UAAGUGCGCGCAUGUAUAUGCG

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Mutations and SNPs

[ - ] NCBI's dbSNP

[ - ] Somatic Mutations in Cancer - Sanger's COSMIC

The mutation data was obtained from the Sanger Institute Catalogue Of Somatic Mutations In Cancer web site, Bamford et al (2004) The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website. Br J Cancer, 91,355-358.
Mutation (top 10)Total Observations
Primary Site / Histology (Top 10)Mutations (sites * observations)
pancreas / carcinoma4
kidney / carcinoma1


[ - ] Genes and Diseases - MIM at NCBI

Chemicals and Drugs

[ - ] Comparative Toxicogenomics Database from MDI Biological Lab

Curated [chemical–gene interactions|chemical–disease|gene–disease] data were retrieved from the Comparative Toxicogenomics Database (CTD), Mount Desert Island Biological Laboratory, Salisbury Cove, Maine. World Wide Web (URL: [Jan. 2009].
Chemical and Interaction
  • Dust results in decreased expression of ACVR1B mRNA

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ACVR1 ACVR1B / ACVR1 Affinity Capture-Western De Winter JP (1996)
ACVR2A ACVR1B / ACVR2A Affinity Capture-Western De Winter JP (1996)
ACVR2A ACVR1B / ACVR2A Affinity Capture-Western Lebrun JJ (1999)
ACVR2B ACVR2B / ACVR1B Affinity Capture-Western De Winter JP (1996)
ACVR2B ACVR2B / ACVR1B Co-purification Attisano L (1996)
BMPR2 BMPR2 / ACVR1B Two-hybrid Liu F (1995)
INHBA INHBA / ACVR1B Affinity Capture-Western Martens JW (1997)
INHBB INHBB / ACVR1B Affinity Capture-Western Martens JW (1997)
SMAD2 ACVR1B / SMAD2 Affinity Capture-Western Lebrun JJ (1999)
SMAD3 ACVR1B / SMAD3 Affinity Capture-Western Lebrun JJ (1999)
Smad7 Smad7 / ACVR1B Affinity Capture-Western Souchelnytskyi S (1998)
SMAD7 ACVR1B / SMAD7 Affinity Capture-Western Liu X (2002)
SNX1 SNX1 / ACVR1B Affinity Capture-Western Parks WT (2001)
SNX2 SNX2 / ACVR1B Affinity Capture-Western Parks WT (2001)
TDGF1 TDGF1 / ACVR1B Reconstituted Complex Bianco C (2002)

Transcript Cluster

[ - ] NCBI's UniGene

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Calvanese L, et al. (2009) "Structural insights into the interaction between the Cripto CFC domain and the ALK4 receptor." J Pept Sci. 15(3):175-183. PMID:19035567
  2. [ + ] Wang Q, et al. (2008) "MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4." Blood. 111(2):588-595. PMID:17906079
  3. [ + ] Esguerra CV, et al. (2007) "Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination." Development. 134(24):4381-4393. PMID:18039968
  4. [ + ] Yamaguchi T, et al. (2006) "FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor." J Mol Endocrinol. 36(3):569-579. PMID:16720724
  5. [ + ] Tsuchida K, et al. (2004) "Activin isoforms signal through type I receptor serine/threonine kinase ALK7." Mol Cell Endocrinol. 220(1-2):59-65. PMID:15196700
  6. [ + ] Gerhard DS, et al. (2004) "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14(10B):2121-2127. PMID:15489334
  7. [ + ] Zhang L, et al. (2004) "Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors." Science. 306(5693):114-117. PMID:15459392
  8. [ + ] Harrison CA, et al. (2004) "An activin mutant with disrupted ALK4 binding blocks signaling via type II receptors." J Biol Chem. 279(27):28036-28044. PMID:15123686
  9. [ + ] Casagrandi D, et al. (2003) "Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia." Mol Hum Reprod. 9(4):199-203. PMID:12651901
  10. [ + ] Rebbapragada A, et al. (2003) "Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis." Mol Cell Biol. 23(20):7230-7242. PMID:14517293
  11. [ + ] Harrison CA, et al. (2003) "Identification of a functional binding site for activin on the type I receptor ALK4." J Biol Chem. 278(23):21129-21135. PMID:12665502
  12. [ + ] Mukasa C, et al. (2003) "Activin signaling through type IB activin receptor stimulates aromatase activity in the ovarian granulosa cell-like human granulosa (KGN) cells." Endocrinology. 144(4):1603-1611. PMID:12639945
  13. [ + ] Bianco C, et al. (2002) "Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells." Mol Cell Biol. 22(8):2586-2597. PMID:11909953
  14. [ + ] Schneider-Kolsky ME, et al. (2002) "The distribution of activin and activin receptors in gestational tissues across human pregnancy and during labour." Placenta. 23(4):294-302. PMID:11969340
  15. [ + ] Liu X, et al. (2002) "Phosphorylation regulation of the interaction between Smad7 and activin type I receptor." FEBS Lett. 519(1-3):93-98. PMID:12023024
  16. [ + ] Welt CK, et al. (2002) "The physiology and pathophysiology of inhibin, activin and follistatin in female reproduction." Curr Opin Obstet Gynecol. 14(3):317-323. PMID:12032389
  17. [ + ] Inman GJ, et al. (2002) "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7." Mol Pharmacol. 62(1):65-74. PMID:12065756
  18. [ + ] Maguire PB, et al. (2002) "Identification of the phosphotyrosine proteome from thrombin activated platelets." Proteomics. 2(6):642-648. PMID:12112843
  19. [ + ] Danila DC, et al. (2002) "Overexpression of wild-type activin receptor alk4-1 restores activin antiproliferative effects in human pituitary tumor cells." J Clin Endocrinol Metab. 87(10):4741-4746. PMID:12364468
  20. [ + ] Strausberg RL, et al. (2002) "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." Proc Natl Acad Sci U S A. 99(26):16899-16903. PMID:12477932
  21. [ + ] Chapman SC, et al. (2001) "Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP)." Mol Endocrinol. 15(4):668-679. PMID:11266516
  22. [ + ] Su GH, et al. (2001) "ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma." Proc Natl Acad Sci U S A. 98(6):3254-3257. PMID:11248065
  23. [ + ] Birkey Reffey S, et al. (2001) "X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling." J Biol Chem. 276(28):26542-26549. PMID:11356828
  24. [ + ] Parks WT, et al. (2001) "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases." J Biol Chem. 276(22):19332-19339. PMID:11279102
  25. [ + ] Wurthner JU, et al. (2001) "Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone." J Biol Chem. 276(22):19495-19502. PMID:11278302
  26. [ + ] Gray PC, et al. (2000) "Identification of a binding site on the type II activin receptor for activin and inhibin." J Biol Chem. 275(5):3206-3212. PMID:10652306
  27. [ + ] Zhou Y, et al. (2000) "Truncated activin type I receptor Alk4 isoforms are dominant negative receptors inhibiting activin signaling." Mol Endocrinol. 14(12):2066-2075. PMID:11117535
  28. [ + ] Lebrun JJ, et al. (1999) "Roles of pathway-specific and inhibitory Smads in activin receptor signaling." Mol Endocrinol. 13(1):15-23. PMID:9892009
  29. [ + ] Souchelnytskyi S, et al. (1998) "Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors." J Biol Chem. 273(39):25364-25370. PMID:9738003
  30. [ + ] Hashimoto O, et al. (1998) "The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells." Cell Signal. 10(10):743-749. PMID:9884026
  31. [ + ] Roijer E, et al. (1998) "Chromosomal localization of three human genes encoding members of the TGF-beta superfamily of type I serine/threonine kinase receptors." Mamm Genome. 9(3):266-268. PMID:9501322
  32. [ + ] Martens JW, et al. (1997) "Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells." Endocrinology. 138(7):2928-2936. PMID:9202237
  33. [ + ] Lebrun JJ, et al. (1997) "Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation." Mol Cell Biol. 17(3):1682-1691. PMID:9032295
  34. [ + ] De Winter JP, et al. (1996) "Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors." Exp Cell Res. 224(2):323-334. PMID:8612709
  35. [ + ] Attisano L, et al. (1996) "Activation of signalling by the activin receptor complex." Mol Cell Biol. 16(3):1066-1073. PMID:8622651
  36. [ + ] Liu F, et al. (1995) "Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs." Mol Cell Biol. 15(7):3479-3486. PMID:7791754
  37. [ + ] Xu J, et al. (1994) "Genomic structure and cloned cDNAs predict that four variants in the kinase domain of serine/threonine kinase receptors arise by alternative splicing and poly(A) addition." Proc Natl Acad Sci U S A. 91(17):7957-7961. PMID:8058741
  38. [ + ] Carcamo J, et al. (1994) "Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin." Mol Cell Biol. 14(6):3810-3821. PMID:8196624
  39. [ + ] ten Dijke P, et al. (1993) "Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity." Oncogene. 8(10):2879-2887. PMID:8397373