ADK2 | GeneID:856917 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 856917 Official Symbol ADK2
Locus YER170W Gene Type protein-coding
Synonyms AKY3; PAK3
Full Name N/A
Description Adk2p
Chromosome N/A
Also Known As Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 21744

ID Symbol Protein Species
GeneID:26956 Ak3 NP_037350.1 Rattus norvegicus
GeneID:41318 Adk3 NP_524312.1 Drosophila melanogaster
GeneID:50808 AK3 NP_057366.2 Homo sapiens
GeneID:56248 Ak3 NP_067274.1 Mus musculus
GeneID:174608 ZK673.2 NP_496245.1 Caenorhabditis elegans
GeneID:281613 AK3L1 NP_776662.1 Bos taurus
GeneID:406404 ak3l1 NP_998295.1 Danio rerio
GeneID:426534 AK3 XP_424173.2 Gallus gallus
GeneID:464977 AK3L1 XP_001138039.1 Pan troglodytes
GeneID:480745 LOC480745 XP_537864.2 Canis lupus familiaris
GeneID:608853 LOC608853 XP_851083.1 Canis lupus familiaris
GeneID:856917 ADK2 NP_011097.1 Saccharomyces cerevisiae
GeneID:1279044 AgaP_AGAP009660 XP_318704.2 Anopheles gambiae
GeneID:2676490 MGG_03683 XP_361140.1 Magnaporthe grisea
GeneID:2712452 NCU03216.1 XP_330652.1 Neurospora crassa
GeneID:2892158 KLLA0C17754g XP_452993.1 Kluyveromyces lactis
GeneID:4623083 AGOS_AGR115C NP_986781.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005743 Component mitochondrial inner membrane
GO:0005739 Component mitochondrion
GO:0004017 Function adenylate kinase activity
GO:0005524 Function ATP binding
GO:0016301 Function kinase activity
GO:0019205 Function nucleobase, nucleoside, nucleotide kinase activity
GO:0046899 Function nucleoside triphosphate adenylate kinase activity
GO:0000166 Function nucleotide binding
GO:0019201 Function nucleotide kinase activity
GO:0016776 Function phosphotransferase activity, phosphate group as acceptor
GO:0016740 Function transferase activity
GO:0006139 Process nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GO:0009117 Process nucleotide metabolic process
GO:0006412 Process translation

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
DUO1 ADK2 / DUO1 PCA Tarassov K (2008)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  2. [ + ] Tarassov K, et al. (2008) "An in vivo map of the yeast protein interactome." Science. 320(5882):1465-1470. PMID:18467557
  3. [ + ] Reinders J, et al. (2006) "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." J Proteome Res. 5(7):1543-1554. PMID:16823961
  4. [ + ] Gu Y, et al. (2005) "A GTP:AMP phosphotransferase, Adk2p, in Saccharomyces cerevisiae. Role of the C terminus in protein folding/stabilization, thermal tolerance, and enzymatic activity." J Biol Chem. 280(19):18604-18609. PMID:15753074
  5. [ + ] Dietrich FS, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Nature. 387(6632 Suppl):78-81. PMID:9169868
  6. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  7. [ + ] Schricker R, et al. (1995) "Strain-dependent occurrence of functional GTP:AMP phosphotransferase (AK3) in Saccharomyces cerevisiae." J Biol Chem. 270(52):31103-31110. PMID:8537371