AFG1 | GeneID:856658 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 856658 Official Symbol AFG1
Locus YEL052W Gene Type protein-coding
Full Name N/A
Description Afg1p
Chromosome N/A
Also Known As Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 5782

ID Symbol Protein Species
GeneID:36357 CG8520 NP_610780.1 Drosophila melanogaster
GeneID:172427 C30F12.2 NP_491986.1 Caenorhabditis elegans
GeneID:215951 Lace1 NP_665686.2 Mus musculus
GeneID:246269 LACE1 NP_660358.2 Homo sapiens
GeneID:421770 LACE1 XP_419799.2 Gallus gallus
GeneID:462920 LACE1 XP_518672.2 Pan troglodytes
GeneID:481952 LACE1 XP_539073.2 Canis lupus familiaris
GeneID:537689 LACE1 XP_617866.3 Bos taurus
GeneID:555926 si:ch211-278n15.1 NP_001020653.2 Danio rerio
GeneID:828922 AT4G28070 NP_001031737.1 Arabidopsis thaliana
GeneID:829172 AT4G30490 NP_567847.1 Arabidopsis thaliana
GeneID:856658 AFG1 NP_010862.1 Saccharomyces cerevisiae
GeneID:1279286 AgaP_AGAP009867 XP_318985.2 Anopheles gambiae
GeneID:2540093 SPBC115.02c NP_595259.1 Schizosaccharomyces pombe
GeneID:2681796 MGG_12248 XP_365949.2 Magnaporthe grisea
GeneID:2705649 NCU04481.1 XP_323834.1 Neurospora crassa
GeneID:2896478 KLLA0A01947g XP_451086.1 Kluyveromyces lactis
GeneID:4345118 Os08g0265500 NP_001061401.1 Oryza sativa
GeneID:4618549 AGOS_AAR132C NP_982674.1 Eremothecium gossypii
GeneID:100150030 LOC100150030 XP_001923655.1 Danio rerio

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005743 Component mitochondrial inner membrane
GO:0005739 Component mitochondrion
GO:0005524 Function ATP binding
GO:0003674 Function molecular_function
GO:0000166 Function nucleotide binding
GO:0006515 Process misfolded or incompletely synthesized protein catabolic process
GO:0055114 Process oxidation reduction
GO:0016558 Process protein import into peroxisome matrix
GO:0006979 Process response to oxidative stress

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

AAB64990   NP_010862   P32317   S30825  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
COX11 COX11 / AFG1 Dosage Rescue Khalimonchuk O (2007)
PAC10 PAC10 / AFG1 Synthetic Lethality Tong AH (2004)
SCO1 SCO1 / AFG1 Dosage Rescue Khalimonchuk O (2007)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  2. [ + ] Khalimonchuk O, et al. (2007) "Evidence for a pro-oxidant intermediate in the assembly of cytochrome oxidase." J Biol Chem. 282(24):17442-17449. PMID:17430883
  3. [ + ] Reinders J, et al. (2006) "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." J Proteome Res. 5(7):1543-1554. PMID:16823961
  4. [ + ] Tong AH, et al. (2004) "Global mapping of the yeast genetic interaction network." Science. 303(5659):808-813. PMID:14764870
  5. [ + ] Sickmann A, et al. (2003) "The proteome of Saccharomyces cerevisiae mitochondria." Proc Natl Acad Sci U S A. 100(23):13207-13212. PMID:14576278
  6. [ + ] Huh WK, et al. (2003) "Global analysis of protein localization in budding yeast." Nature. 425(6959):686-691. PMID:14562095
  7. [ + ] Dietrich FS, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Nature. 387(6632 Suppl):78-81. PMID:9169868
  8. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441