AFT2 | GeneID:855899 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 855899 Official Symbol AFT2
Locus YPL202C Gene Type protein-coding
Full Name N/A
Description Aft2p
Chromosome N/A
Also Known As Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; similar to Aft1p
Summary N/A

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005739 Component mitochondrion
GO:0005634 Component nucleus
GO:0005506 Function iron ion binding
GO:0043565 Function sequence-specific DNA binding
GO:0003704 Function specific RNA polymerase II transcription factor activity
GO:0003700 Function transcription factor activity
GO:0006879 Process cellular iron ion homeostasis
GO:0045941 Process positive regulation of transcription
GO:0006355 Process regulation of transcription, DNA-dependent
GO:0006979 Process response to oxidative stress
GO:0006350 Process transcription
GO:0006367 Process transcription initiation from RNA polymerase II promoter

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

CAA97916   NP_015122   Q08957   S65221  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
HSP82 HSP82 / AFT2 Synthetic Lethality Zhao R (2005)
RCS1 RCS1 / AFT2 Dosage Rescue Rutherford JC (2001)
RCS1 RCS1 / AFT2 Phenotypic Enhancement Courel M (2005)
RCS1 RCS1 / AFT2 Phenotypic Enhancement Portnoy ME (2002)
RCS1 RCS1 / AFT2 Phenotypic Enhancement Rutherford JC (2001)
RCS1 RCS1 / AFT2 Synthetic Growth Defect Blaiseau PL (2001)
RCS1 RCS1 / AFT2 Synthetic Growth Defect Dubacq C (2006)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Reinders J, et al. (2006) "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." J Proteome Res. 5(7):1543-1554. PMID:16823961
  2. [ + ] Dubacq C, et al. (2006) "Role of the iron mobilization and oxidative stress regulons in the genomic response of yeast to hydroxyurea." Mol Genet Genomics. 275(2):114-124. PMID:16328372
  3. [ + ] Rutherford JC, et al. (2005) "Activation of the iron regulon by the yeast Aft1/Aft2 transcription factors depends on mitochondrial but not cytosolic iron-sulfur protein biogenesis." J Biol Chem. 280(11):10135-10140. PMID:15649888
  4. [ + ] Courel M, et al. (2005) "Direct activation of genes involved in intracellular iron use by the yeast iron-responsive transcription factor Aft2 without its paralog Aft1." Mol Cell Biol. 25(15):6760-6771. PMID:16024809
  5. [ + ] Zhao R, et al. (2005) "Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone." Cell. 120(5):715-727. PMID:15766533
  6. [ + ] Sickmann A, et al. (2003) "The proteome of Saccharomyces cerevisiae mitochondria." Proc Natl Acad Sci U S A. 100(23):13207-13212. PMID:14576278
  7. [ + ] Portnoy ME, et al. (2002) "The distinct methods by which manganese and iron regulate the Nramp transporters in yeast." Biochem J. 362(Pt 1):119-124. PMID:11829747
  8. [ + ] Rutherford JC, et al. (2001) "A second iron-regulatory system in yeast independent of Aft1p." Proc Natl Acad Sci U S A. 98(25):14322-14327. PMID:11734641
  9. [ + ] Blaiseau PL, et al. (2001) "Aft2p, a novel iron-regulated transcription activator that modulates, with Aft1p, intracellular iron use and resistance to oxidative stress in yeast." J Biol Chem. 276(36):34221-34226. PMID:11448968
  10. [ + ] Bussey H, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Nature. 387(6632 Suppl):103-105. PMID:9169875
  11. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441