ACM1 | GeneID:855861 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 855861 Official Symbol ACM1
Locus YPL267W Gene Type protein-coding
Synonyms
Full Name N/A
Description Acm1p
Chromosome N/A
Also Known As Cell cycle regulated protein of unknown function; associated with Cdh1p and may supress the APC/C[Cdh1]-mediated proteolysis of mitotic cyclins
Summary N/A

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0005634 Component nucleus
GO:0055105 Function ubiquitin-protein ligase inhibitor activity
GO:0007049 Process cell cycle
GO:0051301 Process cell division
GO:0007067 Process mitosis
GO:0051436 Process negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle
GO:0006355 Process regulation of transcription, DNA-dependent
GO:0006350 Process transcription

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

AAS56465   CAA98002   NP_015056   Q08981   S65300  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
BMH1 ACM1 / BMH1 Affinity Capture-Western Dial JM (2007)
BMH1 BMH1 / ACM1 Affinity Capture-Western Hall MC (2008)
CDC14 ACM1 / CDC14 Affinity Capture-Western Hall MC (2008)
CDC14 CDC14 / ACM1 Affinity Capture-Western Hall MC (2008)
CDC14 CDC14 / ACM1 Biochemical Activity Hall MC (2008)
CDC20 CDC20 / ACM1 Biochemical Activity Enquist-Newman M (2008)
CDC28 CDC28 / ACM1 Biochemical Activity Hall MC (2008)
CDC28 CDC28 / ACM1 Biochemical Activity Ubersax JA (2003)
CDC5 ACM1 / CDC5 Phenotypic Enhancement Crasta K (2008)
CDH1 CDH1 / ACM1 Affinity Capture-MS Dial JM (2007)
CDH1 CDH1 / ACM1 Affinity Capture-MS Hall MC (2008)
CDH1 ACM1 / CDH1 Affinity Capture-Western Dial JM (2007)
CDH1 CDH1 / ACM1 Affinity Capture-Western Hall MC (2008)
CDH1 CDH1 / ACM1 Affinity Capture-Western Ostapenko D (2008)
CDH1 ACM1 / CDH1 Biochemical Activity Enquist-Newman M (2008)
CDH1 CDH1 / ACM1 Biochemical Activity Enquist-Newman M (2008)
CDH1 CDH1 / ACM1 Dosage Rescue Enquist-Newman M (2008)
CDH1 ACM1 / CDH1 Phenotypic Suppression Crasta K (2008)
CDH1 CDH1 / ACM1 Reconstituted Complex Enquist-Newman M (2008)
CDH1 CDH1 / ACM1 Reconstituted Complex Ostapenko D (2008)
CDH1 CDH1 / ACM1 Synthetic Rescue Hall MC (2008)
CLB2 CLB2 / ACM1 Biochemical Activity Ubersax JA (2003)
CLB3 CLB3 / ACM1 Affinity Capture-MS Archambault V (2004)
CLN2 CLN2 / ACM1 Affinity Capture-MS Archambault V (2004)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Hall MC, et al. (2008) "Cdc28 and Cdc14 control stability of the anaphase-promoting complex inhibitor Acm1." J Biol Chem. 283(16):10396-10407. PMID:18287090
  2. [ + ] Choi E, et al. (2008) "Unique D box and KEN box sequences limit ubiquitination of Acm1 and promote pseudosubstrate inhibition of the anaphase-promoting complex." J Biol Chem. 283(35):23701-23710. PMID:18596038
  3. [ + ] Ostapenko D, et al. (2008) "Pseudosubstrate inhibition of the anaphase-promoting complex by Acm1: regulation by proteolysis and Cdc28 phosphorylation." Mol Cell Biol. 28(15):4653-4664. PMID:18519589
  4. [ + ] Crasta K, et al. (2008) "Inactivation of Cdh1 by synergistic action of Cdk1 and polo kinase is necessary for proper assembly of the mitotic spindle." Nat Cell Biol. 10(6):665-675. PMID:18500339
  5. [ + ] Enquist-Newman M, et al. (2008) "Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1." Mol Cell. 30(4):437-446. PMID:18498748
  6. [ + ] Dial JM, et al. (2007) "Inhibition of APCCdh1 activity by Cdh1/Acm1/Bmh1 ternary complex formation." J Biol Chem. 282(8):5237-5248. PMID:17178718
  7. [ + ] Martinez JS, et al. (2006) "Acm1 is a negative regulator of the CDH1-dependent anaphase-promoting complex/cyclosome in budding yeast." Mol Cell Biol. 26(24):9162-9176. PMID:17030612
  8. [ + ] Archambault V, et al. (2004) "Targeted proteomic study of the cyclin-Cdk module." Mol Cell. 14(6):699-711. PMID:15200949
  9. [ + ] Ubersax JA, et al. (2003) "Targets of the cyclin-dependent kinase Cdk1." Nature. 425(6960):859-864. PMID:14574415
  10. [ + ] Bussey H, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Nature. 387(6632 Suppl):103-105. PMID:9169875
  11. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441