ACC1 | GeneID:855750 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 855750 Official Symbol ACC1
Locus YNR016C Gene Type protein-coding
Synonyms ABP2; FAS3; MTR7
Full Name N/A
Description Acc1p
Chromosome N/A
Also Known As Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 31015

ID Symbol Protein Species
GeneID:31 ACACA NP_942131.1 Homo sapiens
GeneID:35761 CG11198 NP_610342.1 Drosophila melanogaster
GeneID:60581 Acaca NP_071529.1 Rattus norvegicus
GeneID:107476 Acaca NP_579938.2 Mus musculus
GeneID:281590 ACACA NP_776649.1 Bos taurus
GeneID:396504 ACACA NP_990836.1 Gallus gallus
GeneID:454602 ACACA XP_511428.2 Pan troglodytes
GeneID:491130 ACACA XP_548250.2 Canis lupus familiaris
GeneID:559403 im:7138837 XP_001919815.1 Danio rerio
GeneID:812246 PF14_0664 XP_001348838.1 Plasmodium falciparum
GeneID:840521 ACC1 NP_174849.2 Arabidopsis thaliana
GeneID:855750 ACC1 NP_014413.1 Saccharomyces cerevisiae
GeneID:1274881 AgaP_AGAP005175 XP_314071.2 Anopheles gambiae
GeneID:2543344 cut6 NP_593271.1 Schizosaccharomyces pombe
GeneID:2683533 MGG_07613 XP_367702.2 Magnaporthe grisea
GeneID:2711503 NCU08535.1 XP_329580.1 Neurospora crassa
GeneID:2895282 KLLA0F06072g XP_455355.1 Kluyveromyces lactis
GeneID:4348450 Os10g0363300 NP_001064439.1 Oryza sativa
GeneID:4618419 AGOS_AAR071W NP_982612.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0005789 Component endoplasmic reticulum membrane
GO:0005739 Component mitochondrion
GO:0003989 Function acetyl-CoA carboxylase activity
GO:0005524 Function ATP binding
GO:0009374 Function biotin binding
GO:0004075 Function biotin carboxylase activity
GO:0003824 Function catalytic activity
GO:0016874 Function ligase activity
GO:0030145 Function manganese ion binding
GO:0046872 Function metal ion binding
GO:0000166 Function nucleotide binding
GO:0043284 Process biopolymer biosynthetic process
GO:0006633 Process fatty acid biosynthetic process
GO:0008610 Process lipid biosynthetic process
GO:0008152 Process metabolic process
GO:0006998 Process nuclear envelope organization
GO:0006606 Process protein import into nucleus
GO:0006417 Process regulation of translation
GO:0006412 Process translation

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

CAA96294   NP_014413   Q00955   S63347  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ACC1 ACC1 / ACC1 Co-crystal Structure Zhang H (2003)
APQ12 ACC1 / APQ12 Phenotypic Suppression Scarcelli JJ (2007)
APQ12 APQ12 / ACC1 Synthetic Growth Defect Scarcelli JJ (2007)
BRR2 BRR2 / ACC1 Two-hybrid van Nues RW (2001)
CCT5 ACC1 / CCT5 Affinity Capture-MS Gavin AC (2002)
CCT5 ACC1 / CCT5 Affinity Capture-MS Gavin AC (2006)
DMC1 DMC1 / ACC1 Affinity Capture-MS Ho Y (2002)
DMC1 DMC1 / ACC1 Two-hybrid Dresser ME (1997)
HFA1 ACC1 / HFA1 Affinity Capture-MS Krogan NJ (2006)
HPR1 ACC1 / HPR1 Synthetic Lethality Schneiter R (1999)
HSP82 HSP82 / ACC1 Affinity Capture-MS Zhao R (2005)
MAE1 MAE1 / ACC1 Affinity Capture-MS Gavin AC (2006)
MRPL22 MRPL22 / ACC1 Affinity Capture-MS Gavin AC (2006)
N/A ACC1 / N/A Affinity Capture-MS Krogan NJ (2006)
PRE1 PRE1 / ACC1 Affinity Capture-MS Verma R (2000)
PSA1 ACC1 / PSA1 Affinity Capture-MS Gavin AC (2006)
PSA1 PSA1 / ACC1 Affinity Capture-MS Gavin AC (2006)
PUB1 PUB1 / ACC1 Phenotypic Enhancement Wilmes GM (2008)
RIC1 RIC1 / ACC1 Phenotypic Suppression Wilmes GM (2008)
RPC40 RPC40 / ACC1 Affinity Capture-MS Ho Y (2002)
SHS1 SHS1 / ACC1 Affinity Capture-MS Ho Y (2002)
SIT4 ACC1 / SIT4 Affinity Capture-MS Gavin AC (2002)
SIT4 SIT4 / ACC1 Affinity Capture-MS Gavin AC (2002)
SIT4 ACC1 / SIT4 Affinity Capture-MS Gavin AC (2006)
SIT4 SIT4 / ACC1 Affinity Capture-MS Gavin AC (2006)
SIT4 SIT4 / ACC1 Affinity Capture-MS Ho Y (2002)
SNF1 SNF1 / ACC1 Synthetic Rescue Shirra MK (2001)
SNP1 SNP1 / ACC1 Two-hybrid Fromont-Racine M (1997)
UTP5 UTP5 / ACC1 Affinity Capture-MS Ho Y (2002)
VAC14 ACC1 / VAC14 Affinity Capture-MS Gavin AC (2002)
YKU80 YKU80 / ACC1 Affinity Capture-MS Ho Y (2002)
YPT6 YPT6 / ACC1 Phenotypic Suppression Wilmes GM (2008)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  2. [ + ] Scarcelli JJ, et al. (2007) "The yeast integral membrane protein Apq12 potentially links membrane dynamics to assembly of nuclear pore complexes." J Cell Biol. 178(5):799-812. PMID:17724120
  3. [ + ] Reinders J, et al. (2006) "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." J Proteome Res. 5(7):1543-1554. PMID:16823961
  4. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  5. [ + ] Gavin AC, et al. (2006) "Proteome survey reveals modularity of the yeast cell machinery." Nature. 440(7084):631-636. PMID:16429126
  6. [ + ] Zhao R, et al. (2005) "Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone." Cell. 120(5):715-727. PMID:15766533
  7. [ + ] Sickmann A, et al. (2003) "The proteome of Saccharomyces cerevisiae mitochondria." Proc Natl Acad Sci U S A. 100(23):13207-13212. PMID:14576278
  8. [ + ] Gao H, et al. (2003) "Nuclear accumulation of the small GTPase Gsp1p depends on nucleoporins Nup133p, Rat2p/Nup120p, Nup85p, Nic96p, and the acetyl-CoA carboxylase Acc1p." J Biol Chem. 278(28):25331-25340. PMID:12730220
  9. [ + ] Ho Y, et al. (2002) "Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry." Nature. 415(6868):180-183. PMID:11805837
  10. [ + ] Gavin AC, et al. (2002) "Functional organization of the yeast proteome by systematic analysis of protein complexes." Nature. 415(6868):141-147. PMID:11805826
  11. [ + ] van Nues RW, et al. (2001) "Functional contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae." Genetics. 157(4):1451-1467. PMID:11290703
  12. [ + ] Shirra MK, et al. (2001) "Inhibition of acetyl coenzyme A carboxylase activity restores expression of the INO1 gene in a snf1 mutant strain of Saccharomyces cerevisiae." Mol Cell Biol. 21(17):5710-5722. PMID:11486011
  13. [ + ] Verma R, et al. (2000) "Proteasomal proteomics: identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomes." Mol Biol Cell. 11(10):3425-3439. PMID:11029046
  14. [ + ] Schneiter R, et al. (1999) "The Saccharomyces cerevisiae hyperrecombination mutant hpr1Delta is synthetically lethal with two conditional alleles of the acetyl coenzyme A carboxylase gene and causes a defect in nuclear export of polyadenylated RNA." Mol Cell Biol. 19(5):3415-3422. PMID:10207065
  15. [ + ] Ivessa AS, et al. (1997) "Yeast acetyl-CoA carboxylase is associated with the cytoplasmic surface of the endoplasmic reticulum." Eur J Cell Biol. 74(4):399-406. PMID:9438137
  16. [ + ] Dresser ME, et al. (1997) "DMC1 functions in a Saccharomyces cerevisiae meiotic pathway that is largely independent of the RAD51 pathway." Genetics. 147(2):533-544. PMID:9335591
  17. [ + ] Fromont-Racine M, et al. (1997) "Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens." Nat Genet. 16(3):277-282. PMID:9207794
  18. [ + ] Fabre E, et al. (1997) "Yeast genetics to dissect the nuclear pore complex and nucleocytoplasmic trafficking." Annu Rev Genet. 31():277-313. PMID:9442897
  19. [ + ] Philippsen P, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Nature. 387(6632 Suppl):93-98. PMID:9169873
  20. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  21. [ + ] Hasslacher M, et al. (1993) "Acetyl-CoA carboxylase from yeast is an essential enzyme and is regulated by factors that control phospholipid metabolism." J Biol Chem. 268(15):10946-10952. PMID:8098706
  22. [ + ] Al-Feel W, et al. (1992) "Cloning of the yeast FAS3 gene and primary structure of yeast acetyl-CoA carboxylase." Proc Natl Acad Sci U S A. 89(10):4534-4538. PMID:1350093
  23. [ + ] Mishina M, et al. (1980) "Yeast mutants defective in acetyl-coenzyme A carboxylase and biotin: apocarboxylase ligase." Eur J Biochem. 111(1):79-87. PMID:6108218