AAH1 | GeneID:855581 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 855581 Official Symbol AAH1
Locus YNL141W Gene Type protein-coding
Full Name N/A
Description Aah1p
Chromosome N/A
Also Known As Adenine deaminase (adenine aminohydrolase), involved in purine salvage and nitrogen catabolism
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 37249

ID Symbol Protein Species
GeneID:100 ADA NP_000013.2 Homo sapiens
GeneID:11486 Ada NP_031424.1 Mus musculus
GeneID:24165 Ada NP_569083.1 Rattus norvegicus
GeneID:177469 C06G3.5 NP_501087.1 Caenorhabditis elegans
GeneID:280712 ADA NP_776312.1 Bos taurus
GeneID:419194 ADA NP_001006290.1 Gallus gallus
GeneID:436919 ada NP_001002646.1 Danio rerio
GeneID:477236 ADA XP_534428.2 Canis lupus familiaris
GeneID:741760 ADA XP_001144517.1 Pan troglodytes
GeneID:810446 PF10_0289 XP_001347573.1 Plasmodium falciparum
GeneID:855581 AAH1 NP_014258.1 Saccharomyces cerevisiae
GeneID:2540066 dea2 NP_595071.1 Schizosaccharomyces pombe
GeneID:2894386 KLLA0E23254g XP_454997.1 Kluyveromyces lactis

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0005634 Component nucleus
GO:0000034 Function adenine deaminase activity
GO:0004000 Function adenosine deaminase activity
GO:0019239 Function deaminase activity
GO:0016787 Function hydrolase activity
GO:0006146 Process adenine catabolic process
GO:0043103 Process hypoxanthine salvage
GO:0009117 Process nucleotide metabolic process
GO:0009168 Process purine ribonucleoside monophosphate biosynthetic process
GO:0043101 Process purine salvage

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

CAA86885   CAA96024   CAN08429   NP_014258   P53909   S55143  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
AAH1 AAH1 / AAH1 Affinity Capture-MS Krogan NJ (2004)
ADE4 ADE4 / AAH1 Phenotypic Enhancement Jakubowski H (1988)
APT1 APT1 / AAH1 Phenotypic Enhancement Jakubowski H (1988)
ESA1 ESA1 / AAH1 Synthetic Growth Defect Mitchell L (2008)
GEM1 GEM1 / AAH1 Synthetic Growth Defect Frederick RL (2008)
LIA1 LIA1 / AAH1 Synthetic Lethality Tong AH (2004)
N/A N/A / AAH1 Affinity Capture-MS Collins SR (2007)
N/A N/A / AAH1 Affinity Capture-MS Ho Y (2002)
N/A N/A / AAH1 Two-hybrid Escusa S (2007)
SKP1 SKP1 / AAH1 Synthetic Growth Defect Measday V (2005)
VID21 VID21 / AAH1 Synthetic Growth Defect Mitchell L (2008)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Frederick RL, et al. (2008) "Multiple pathways influence mitochondrial inheritance in budding yeast." Genetics. 178(2):825-837. PMID:18245340
  2. [ + ] Mitchell L, et al. (2008) "Functional dissection of the NuA4 histone acetyltransferase reveals its role as a genetic hub and that Eaf1 is essential for complex integrity." Mol Cell Biol. 28(7):2244-2256. PMID:18212056
  3. [ + ] Escusa S, et al. (2007) "Skp1-Cullin-F-box-dependent degradation of Aah1p requires its interaction with the F-box protein Saf1p." J Biol Chem. 282(28):20097-20103. PMID:17517885
  4. [ + ] Collins SR, et al. (2007) "Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae." Mol Cell Proteomics. 6(3):439-450. PMID:17200106
  5. [ + ] Escusa S, et al. (2006) "Proteasome- and SCF-dependent degradation of yeast adenine deaminase upon transition from proliferation to quiescence requires a new F-box protein named Saf1p." Mol Microbiol. 60(4):1014-1025. PMID:16677311
  6. [ + ] Measday V, et al. (2005) "Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation." Proc Natl Acad Sci U S A. 102(39):13956-13961. PMID:16172405
  7. [ + ] Tong AH, et al. (2004) "Global mapping of the yeast genetic interaction network." Science. 303(5659):808-813. PMID:14764870
  8. [ + ] Krogan NJ, et al. (2004) "High-definition macromolecular composition of yeast RNA-processing complexes." Mol Cell. 13(2):225-239. PMID:14759368
  9. [ + ] Huh WK, et al. (2003) "Global analysis of protein localization in budding yeast." Nature. 425(6959):686-691. PMID:14562095
  10. [ + ] Ho Y, et al. (2002) "Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry." Nature. 415(6868):180-183. PMID:11805837
  11. [ + ] Philippsen P, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Nature. 387(6632 Suppl):93-98. PMID:9169873
  12. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  13. [ + ] Deeley MC, et al. (1992) "Adenine deaminase and adenine utilization in Saccharomyces cerevisiae." J Bacteriol. 174(10):3102-3110. PMID:1577682
  14. [ + ] Jakubowski H, et al. (1988) "Evidence for cooperation between cells during sporulation of the yeast Saccharomyces cerevisiae." Mol Cell Biol. 8(12):5166-5178. PMID:3072477