ADE12 | GeneID:855501 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 855501 Official Symbol ADE12
Locus YNL220W Gene Type protein-coding
Synonyms BRA9
Full Name N/A
Description Ade12p
Chromosome N/A
Also Known As Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 111992

ID Symbol Protein Species
GeneID:11565 Adssl1 NP_031447.1 Mus musculus
GeneID:122622 ADSSL1 NP_689541.1 Homo sapiens
GeneID:407989 adssl1 NP_999985.1 Danio rerio
GeneID:467568 ADSSL1 XP_522963.2 Pan troglodytes
GeneID:612692 ADSSL1 XP_855512.1 Canis lupus familiaris
GeneID:776127 ADSSL1 XP_001235680.1 Gallus gallus
GeneID:784089 ADSSL1 XP_001251819.1 Bos taurus
GeneID:814251 PF13_0287 XP_001350257.1 Plasmodium falciparum
GeneID:824930 ATPURA NP_191320.1 Arabidopsis thaliana
GeneID:855501 ADE12 NP_014179.1 Saccharomyces cerevisiae
GeneID:2542823 ade2 NP_594664.1 Schizosaccharomyces pombe
GeneID:2682892 MGG_10691 XP_367061.2 Magnaporthe grisea
GeneID:2712324 NCU09789.1 XP_330439.1 Neurospora crassa
GeneID:2893507 KLLA0D19426g XP_453924.1 Kluyveromyces lactis
GeneID:4331792 Os03g0174500 NP_001049128.1 Oryza sativa
GeneID:4333815 Os03g0699300 NP_001050987.1 Oryza sativa
GeneID:4618841 AGOS_ABL186W NP_982761.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0004019 Function adenylosuccinate synthase activity
GO:0003677 Function DNA binding
GO:0003688 Function DNA replication origin binding
GO:0005525 Function GTP binding
GO:0016874 Function ligase activity
GO:0000287 Function magnesium ion binding
GO:0046872 Function metal ion binding
GO:0000166 Function nucleotide binding
GO:0043094 Process cellular metabolic compound salvage
GO:0018193 Process peptidyl-amino acid modification
GO:0006164 Process purine nucleotide biosynthetic process
GO:0006417 Process regulation of translation

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

AAA91338   CAA88590   CAA96123   NP_014179   P80210   S48515  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
REG1 ADE12 / REG1 Affinity Capture-MS Krogan NJ (2006)
RSP5 RSP5 / ADE12 Reconstituted Complex Gupta R (2007)
SMT3 SMT3 / ADE12 Affinity Capture-MS Panse VG (2004)
TUF1 ADE12 / TUF1 Affinity Capture-MS Krogan NJ (2006)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  2. [ + ] Gupta R, et al. (2007) "Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast." Mol Syst Biol. 3():116. PMID:17551511
  3. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  4. [ + ] Panse VG, et al. (2004) "A proteome-wide approach identifies sumoylated substrate proteins in yeast." J Biol Chem. 279(40):41346-41351. PMID:15292183
  5. [ + ] Huh WK, et al. (2003) "Global analysis of protein localization in budding yeast." Nature. 425(6959):686-691. PMID:14562095
  6. [ + ] Lipps G, et al. (1999) "Adenylosuccinate synthase from Saccharomyces cerevisiae: homologous overexpression, purification and characterization of the recombinant protein." Biochem J. 341 ( Pt 3)():537-543. PMID:10417315
  7. [ + ] Philippsen P, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Nature. 387(6632 Suppl):93-98. PMID:9169873
  8. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  9. [ + ] Gallert KC, et al. (1996) "Enzymatic properties and inhibition by single-stranded autonomously replicating sequences of adenylosuccinate synthase from Saccharomyces cerevisiae." Eur J Biochem. 239(2):487-493. PMID:8706758
  10. [ + ] Dorfman BZ, et al. (1969) "The isolation of adenylosuccinate synthetase mutants in yeast by selection for constitutive behavior in pigmented strains." Genetics. 61(2):377-389. PMID:5807803