ADH6 | GeneID:855368 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 855368 Official Symbol ADH6
Locus YMR318C Gene Type protein-coding
Synonyms ADHVI
Full Name N/A
Description Adh6p
Chromosome N/A
Also Known As NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 112107

ID Symbol Protein Species
GeneID:816710 AT2G21730 NP_179765.1 Arabidopsis thaliana
GeneID:816725 AT2G21890 NP_179780.1 Arabidopsis thaliana
GeneID:829953 AT4G37970 NP_195510.1 Arabidopsis thaliana
GeneID:829954 ELI3-1 NP_195511.1 Arabidopsis thaliana
GeneID:829955 ELI3-2 NP_195512.1 Arabidopsis thaliana
GeneID:830088 AT4G39330 NP_195643.1 Arabidopsis thaliana
GeneID:850469 ADH7 NP_010030.1 Saccharomyces cerevisiae
GeneID:855368 ADH6 NP_014051.1 Saccharomyces cerevisiae
GeneID:2674858 MGG_00220 XP_369024.2 Magnaporthe grisea
GeneID:2704205 NCU00260.1 XP_322346.1 Neurospora crassa
GeneID:2894727 KLLA0E19987g XP_454851.1 Kluyveromyces lactis
GeneID:4336968 Os04g0612700 NP_001053848.1 Oryza sativa
GeneID:4345137 Os08g0270400 NP_001061418.1 Oryza sativa
GeneID:4348690 Os10g0430200 NP_001064659.1 Oryza sativa

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005625 Component soluble fraction
GO:0008106 Function alcohol dehydrogenase (NADP+) activity
GO:0005488 Function binding
GO:0003824 Function catalytic activity
GO:0033833 Function hydroxymethylfurfural reductase (NADH) activity
GO:0033845 Function hydroxymethylfurfural reductase (NADPH) activity
GO:0046872 Function metal ion binding
GO:0016491 Function oxidoreductase activity
GO:0008270 Function zinc ion binding
GO:0043284 Process biopolymer biosynthetic process
GO:0045454 Process cell redox homeostasis
GO:0006066 Process cellular alcohol metabolic process
GO:0006081 Process cellular aldehyde metabolic process
GO:0043094 Process cellular metabolic compound salvage
GO:0033859 Process furaldehyde metabolic process
GO:0008152 Process metabolic process
GO:0055114 Process oxidation reduction
GO:0006417 Process regulation of translation
GO:0006412 Process translation

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

1PIW-A   1PIW-B   1PS0-A   1Q1N-A   CAA90836   NP_014051   Q04894   S59311  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ADH6 ADH6 / ADH6 Co-crystal Structure Valencia E (2004)
GAS1 GAS1 / ADH6 Synthetic Lethality Lesage G (2004)
GAS1 GAS1 / ADH6 Synthetic Lethality Tong AH (2004)
RAD26 RAD26 / ADH6 Affinity Capture-MS Ho Y (2002)
SIR3 SIR3 / ADH6 Affinity Capture-MS Ho Y (2002)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  2. [ + ] Petersson A, et al. (2006) "A 5-hydroxymethyl furfural reducing enzyme encoded by the Saccharomyces cerevisiae ADH6 gene conveys HMF tolerance." Yeast. 23(6):455-464. PMID:16652391
  3. [ + ] Tong AH, et al. (2004) "Global mapping of the yeast genetic interaction network." Science. 303(5659):808-813. PMID:14764870
  4. [ + ] Lesage G, et al. (2004) "Analysis of beta-1,3-glucan assembly in Saccharomyces cerevisiae using a synthetic interaction network and altered sensitivity to caspofungin." Genetics. 167(1):35-49. PMID:15166135
  5. [ + ] Larroy C, et al. (2002) "Characterization of the Saccharomyces cerevisiae YMR318C (ADH6) gene product as a broad specificity NADPH-dependent alcohol dehydrogenase: relevance in aldehyde reduction." Biochem J. 361(Pt 1):163-172. PMID:11742541
  6. [ + ] Ho Y, et al. (2002) "Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry." Nature. 415(6868):180-183. PMID:11805837
  7. [ + ] Bowman S, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Nature. 387(6632 Suppl):90-93. PMID:9169872
  8. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441