ADH2 | GeneID:855349 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 855349 Official Symbol ADH2
Locus YMR303C Gene Type protein-coding
Synonyms ADR2
Full Name N/A
Description Adh2p
Chromosome N/A
Also Known As Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 113665

ID Symbol Protein Species
GeneID:854068 ADH1 NP_014555.1 Saccharomyces cerevisiae
GeneID:855349 ADH2 NP_014032.1 Saccharomyces cerevisiae
GeneID:2894942 ADH2_KLULA XP_455899.1 Kluyveromyces lactis
GeneID:2895056 ADH1_KLULA XP_456023.1 Kluyveromyces lactis
GeneID:4618556 AGOS_AAR084W NP_982625.1 Eremothecium gossypii
GeneID:4621094 AGOS_AER032W NP_984892.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0004022 Function alcohol dehydrogenase (NAD) activity
GO:0005488 Function binding
GO:0003824 Function catalytic activity
GO:0046872 Function metal ion binding
GO:0016491 Function oxidoreductase activity
GO:0008270 Function zinc ion binding
GO:0000947 Process amino acid catabolic process to alcohol via Ehrlich pathway
GO:0043284 Process biopolymer biosynthetic process
GO:0006067 Process ethanol metabolic process
GO:0006113 Process fermentation
GO:0008152 Process metabolic process
GO:0006116 Process NADH oxidation
GO:0055114 Process oxidation reduction
GO:0006417 Process regulation of translation
GO:0006412 Process translation

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

AAA34408   CAA24602   CAA89136   DEBYA2   NP_014032   P00331  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ADH1 ADH2 / ADH1 Affinity Capture-MS Collins SR (2007)
ADH1 ADH1 / ADH2 Phenotypic Enhancement Kusano M (1998)
ADR1 ADH2 / ADR1 Phenotypic Enhancement Denis CL (1987)
AIR2 AIR2 / ADH2 Affinity Capture-MS Ho Y (2002)
BUD20 BUD20 / ADH2 Affinity Capture-MS Ho Y (2002)
CDC42 CDC42 / ADH2 Affinity Capture-MS Ho Y (2002)
CPR6 CPR6 / ADH2 Affinity Capture-MS Ho Y (2002)
FKH2 FKH2 / ADH2 Affinity Capture-MS Ho Y (2002)
HRT3 HRT3 / ADH2 Affinity Capture-MS Ho Y (2002)
HYM1 HYM1 / ADH2 Affinity Capture-MS Ho Y (2002)
LCD1 LCD1 / ADH2 Affinity Capture-MS Ho Y (2002)
MUS81 MUS81 / ADH2 Affinity Capture-MS Ho Y (2002)
N/A ADH2 / N/A Two-hybrid Uetz P (2000)
RFC4 RFC4 / ADH2 Affinity Capture-MS Ho Y (2002)
RPC40 RPC40 / ADH2 Affinity Capture-MS Ho Y (2002)
SLD2 SLD2 / ADH2 Affinity Capture-MS Ho Y (2002)
YCK1 YCK1 / ADH2 Affinity Capture-MS Ho Y (2002)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  2. [ + ] Young ET, et al. (2008) "Artificial recruitment of mediator by the DNA-binding domain of Adr1 overcomes glucose repression of ADH2 expression." Mol Cell Biol. 28(8):2509-2516. PMID:18250152
  3. [ + ] Collins SR, et al. (2007) "Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae." Mol Cell Proteomics. 6(3):439-450. PMID:17200106
  4. [ + ] Xella B, et al. (2006) "The ISWI and CHD1 chromatin remodelling activities influence ADH2 expression and chromatin organization." Mol Microbiol. 59(5):1531-1541. PMID:16468993
  5. [ + ] Voronkova V, et al. (2006) "Snf1-dependent and Snf1-independent pathways of constitutive ADH2 expression in Saccharomyces cerevisiae." Genetics. 172(4):2123-2138. PMID:16415371
  6. [ + ] Thomson JM, et al. (2005) "Resurrecting ancestral alcohol dehydrogenases from yeast." Nat Genet. 37(6):630-635. PMID:15864308
  7. [ + ] Dickinson JR, et al. (2003) "The catabolism of amino acids to long chain and complex alcohols in Saccharomyces cerevisiae." J Biol Chem. 278(10):8028-8034. PMID:12499363
  8. [ + ] Huh WK, et al. (2003) "Global analysis of protein localization in budding yeast." Nature. 425(6959):686-691. PMID:14562095
  9. [ + ] Kumar A, et al. (2002) "Subcellular localization of the yeast proteome." Genes Dev. 16(6):707-719. PMID:11914276
  10. [ + ] Ho Y, et al. (2002) "Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry." Nature. 415(6868):180-183. PMID:11805837
  11. [ + ] Uetz P, et al. (2000) "A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae." Nature. 403(6770):623-627. PMID:10688190
  12. [ + ] Kusano M, et al. (1998) "Hemiacetal dehydrogenation activity of alcohol dehydrogenases in Saccharomyces cerevisiae." Biosci Biotechnol Biochem. 62(10):1956-1961. PMID:9836432
  13. [ + ] Bowman S, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Nature. 387(6632 Suppl):90-93. PMID:9169872
  14. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  15. [ + ] Ronne H, et al. (1995) "Glucose repression in fungi." Trends Genet. 11(1):12-17. PMID:7900189
  16. [ + ] Denis CL, et al. (1987) "The effects of ADR1 and CCR1 gene dosage on the regulation of the glucose-repressible alcohol dehydrogenase from Saccharomyces cerevisiae." Mol Gen Genet. 208(1-2):101-106. PMID:3302603
  17. [ + ] Ganzhorn AJ, et al. (1987) "Kinetic characterization of yeast alcohol dehydrogenases. Amino acid residue 294 and substrate specificity." J Biol Chem. 262(8):3754-3761. PMID:3546317