ADE4 | GeneID:855346 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 855346 Official Symbol ADE4
Locus YMR300C Gene Type protein-coding
Full Name N/A
Description Ade4p
Chromosome N/A
Also Known As Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 68272

ID Symbol Protein Species
GeneID:5471 PPAT NP_002694.3 Homo sapiens
GeneID:38753 Prat2 NP_523949.2 Drosophila melanogaster
GeneID:40935 Prat NP_524271.2 Drosophila melanogaster
GeneID:117544 Ppat XP_579602.1 Rattus norvegicus
GeneID:175613 Amidophosphoribosyltransferase NP_497958.1 Caenorhabditis elegans
GeneID:231327 Ppat XP_979031.1 Mus musculus
GeneID:422743 PPAT XP_001232005.1 Gallus gallus
GeneID:461309 PPAT XP_001140991.1 Pan troglodytes
GeneID:509652 PPAT XP_586663.3 Bos taurus
GeneID:572027 si:dkeyp-117h8.5 NP_001076346.2 Danio rerio
GeneID:611407 PPAT XP_854170.1 Canis lupus familiaris
GeneID:816156 ATASE NP_179247.1 Arabidopsis thaliana
GeneID:829626 ATASE2 NP_195200.1 Arabidopsis thaliana
GeneID:830043 ATASE3 NP_195599.1 Arabidopsis thaliana
GeneID:855346 ADE4 NP_014029.1 Saccharomyces cerevisiae
GeneID:1272085 AgaP_AGAP000179 XP_310956.2 Anopheles gambiae
GeneID:2543626 ade4 NP_594961.1 Schizosaccharomyces pombe
GeneID:2677934 MGG_04618 XP_362173.2 Magnaporthe grisea
GeneID:2705466 NCU04216.1 XP_323556.1 Neurospora crassa
GeneID:2896821 KLLA0A10109g XP_451442.1 Kluyveromyces lactis
GeneID:4622626 AGOS_AGL334W NP_986333.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0004044 Function amidophosphoribosyltransferase activity
GO:0000287 Function magnesium ion binding
GO:0046872 Function metal ion binding
GO:0016740 Function transferase activity
GO:0016757 Function transferase activity, transferring glycosyl groups
GO:0006189 Process 'de novo' IMP biosynthetic process
GO:0006541 Process glutamine metabolic process
GO:0008152 Process metabolic process
GO:0009116 Process nucleoside metabolic process
GO:0009113 Process purine base biosynthetic process
GO:0006164 Process purine nucleotide biosynthetic process
GO:0042254 Process ribosome biogenesis
GO:0016072 Process rRNA metabolic process

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

CAA89133   NP_014029   P04046   S53970  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
AAH1 ADE4 / AAH1 Phenotypic Enhancement Jakubowski H (1988)
ADE13 ADE13 / ADE4 Dosage Lethality Rebora K (2005)
ADE16 ADE16 / ADE4 Dosage Lethality Rebora K (2005)
ADE17 ADE17 / ADE4 Dosage Lethality Rebora K (2005)
ADE2 ADE2 / ADE4 Phenotypic Suppression Zekhnov AM (1998)
ADE4 ADE4 / ADE4 PCA Tarassov K (2008)
ALG7 ALG7 / ADE4 PCA Tarassov K (2008)
ALO1 ALO1 / ADE4 PCA Tarassov K (2008)
CYS3 ADE4 / CYS3 Affinity Capture-MS Gavin AC (2002)
HPT1 ADE4 / HPT1 Phenotypic Suppression Breton A (2008)
HSC82 HSC82 / ADE4 Synthetic Growth Defect McClellan AJ (2007)
HSP82 HSP82 / ADE4 Synthetic Growth Defect McClellan AJ (2007)
LTE1 LTE1 / ADE4 Affinity Capture-MS Graumann J (2004)
PWP2 PWP2 / ADE4 Affinity Capture-MS Gavin AC (2002)
RNA1 ADE4 / RNA1 Affinity Capture-MS Gavin AC (2002)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  2. [ + ] Tarassov K, et al. (2008) "An in vivo map of the yeast protein interactome." Science. 320(5882):1465-1470. PMID:18467557
  3. [ + ] Breton A, et al. (2008) "Lethal accumulation of guanylic nucleotides in Saccharomyces cerevisiae HPT1-deregulated mutants." Genetics. 178(2):815-824. PMID:18245832
  4. [ + ] McClellan AJ, et al. (2007) "Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches." Cell. 131(1):121-135. PMID:17923092
  5. [ + ] Rebora K, et al. (2005) "Revisiting purine-histidine cross-pathway regulation in Saccharomyces cerevisiae: a central role for a small molecule." Genetics. 170(1):61-70. PMID:15744050
  6. [ + ] Graumann J, et al. (2004) "Applicability of tandem affinity purification MudPIT to pathway proteomics in yeast." Mol Cell Proteomics. 3(3):226-237. PMID:14660704
  7. [ + ] Huh WK, et al. (2003) "Global analysis of protein localization in budding yeast." Nature. 425(6959):686-691. PMID:14562095
  8. [ + ] Gavin AC, et al. (2002) "Functional organization of the yeast proteome by systematic analysis of protein complexes." Nature. 415(6868):141-147. PMID:11805826
  9. [ + ] Rebora K, et al. (2001) "Yeast AMP pathway genes respond to adenine through regulated synthesis of a metabolic intermediate." Mol Cell Biol. 21(23):7901-7912. PMID:11689683
  10. [ + ] Zekhnov AM, et al. (1998) "[New phenotypic manifestation of the ad2 mutation in Saccharomyces cerevisiae yeast--the inability to grow on a synthetic medium with glycerol and hypoxanthine]" Genetika. 34(2):190-197. PMID:9589850
  11. [ + ] Bowman S, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Nature. 387(6632 Suppl):90-93. PMID:9169872
  12. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  13. [ + ] Jakubowski H, et al. (1988) "Evidence for cooperation between cells during sporulation of the yeast Saccharomyces cerevisiae." Mol Cell Biol. 8(12):5166-5178. PMID:3072477
  14. [ + ] Mantsala P, et al. (1984) "Glutamine nucleotide sequence of Saccharomyces cerevisiae ADE4 encoding phosphoribosylpyrophosphate amidotransferase." J Biol Chem. 259(13):8478-8484. PMID:6376509