AEP2 | GeneID:855325 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 855325 Official Symbol AEP2
Locus YMR282C Gene Type protein-coding
Synonyms ATP13
Full Name N/A
Description Aep2p
Chromosome N/A
Also Known As Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 52435

ID Symbol Protein Species
GeneID:855325 AEP2 NP_014009.1 Saccharomyces cerevisiae
GeneID:2893015 KLLA0D01408g XP_453131.1 Kluyveromyces lactis
GeneID:4618908 AGOS_ABL119C NP_982828.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005739 Component mitochondrion
GO:0003674 Function molecular_function
GO:0045333 Process cellular respiration
GO:0070124 Process mitochondrial translational initiation

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

CAA89780   NP_014009   P22136   S54589  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
HRP1 HRP1 / AEP2 Affinity Capture-MS Gavin AC (2002)
HSP82 HSP82 / AEP2 Affinity Capture-MS Zhao R (2005)
HSP82 HSP82 / AEP2 Synthetic Lethality Zhao R (2005)
JNM1 JNM1 / AEP2 Synthetic Lethality Schoner D (2008)
SVP26 SVP26 / AEP2 Synthetic Lethality Tong AH (2004)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  2. [ + ] Schoner D, et al. (2008) "Annotating novel genes by integrating synthetic lethals and genomic information." BMC Syst Biol. 2():3. PMID:18194531
  3. [ + ] Reinders J, et al. (2006) "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." J Proteome Res. 5(7):1543-1554. PMID:16823961
  4. [ + ] Zhao R, et al. (2005) "Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone." Cell. 120(5):715-727. PMID:15766533
  5. [ + ] Tong AH, et al. (2004) "Global mapping of the yeast genetic interaction network." Science. 303(5659):808-813. PMID:14764870
  6. [ + ] Sickmann A, et al. (2003) "The proteome of Saccharomyces cerevisiae mitochondria." Proc Natl Acad Sci U S A. 100(23):13207-13212. PMID:14576278
  7. [ + ] Gavin AC, et al. (2002) "Functional organization of the yeast proteome by systematic analysis of protein complexes." Nature. 415(6868):141-147. PMID:11805826
  8. [ + ] Ellis TP, et al. (1999) "Suppression of a nuclear aep2 mutation in Saccharomyces cerevisiae by a base substitution in the 5'-untranslated region of the mitochondrial oli1 gene encoding subunit 9 of ATP synthase." Genetics. 151(4):1353-1363. PMID:10101162
  9. [ + ] Bowman S, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Nature. 387(6632 Suppl):90-93. PMID:9169872
  10. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  11. [ + ] Finnegan PM, et al. (1995) "The mature AEP2 gene product of Saccharomyces cerevisiae, required for the expression of subunit 9 of ATP synthase, is a 58 kDa mitochondrial protein." FEBS Lett. 368(3):505-508. PMID:7635208