ADE17 | GeneID:855149 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 855149 Official Symbol ADE17
Locus YMR120C Gene Type protein-coding
Synonyms
Full Name N/A
Description Ade17p
Chromosome N/A
Also Known As Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade16p; ade16 ade17 mutants require adenine and histidine
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 2983

ID Symbol Protein Species
GeneID:471 ATIC NP_004035.2 Homo sapiens
GeneID:42973 CG11089 NP_651305.1 Drosophila melanogaster
GeneID:81643 Atic NP_112276.2 Rattus norvegicus
GeneID:108147 Atic NP_080471.1 Mus musculus
GeneID:140622 atic NP_001076265.1 Danio rerio
GeneID:177576 transferase NP_741452.2 Caenorhabditis elegans
GeneID:396091 ATIC NP_990509.1 Gallus gallus
GeneID:459925 ATIC XP_001150375.1 Pan troglodytes
GeneID:488513 ATIC XP_863050.1 Canis lupus familiaris
GeneID:506343 ATIC NP_001068722.1 Bos taurus
GeneID:818069 AT2G35040 NP_850240.1 Arabidopsis thaliana
GeneID:855149 ADE17 NP_013839.1 Saccharomyces cerevisiae
GeneID:1281753 AgaP_AGAP001423 XP_321707.2 Anopheles gambiae
GeneID:2539569 ade10 NP_588027.1 Schizosaccharomyces pombe
GeneID:2677832 MGG_04435 XP_361990.1 Magnaporthe grisea
GeneID:2713697 NCU02629.1 XP_331828.1 Neurospora crassa
GeneID:2895615 KLLA0F17655g XP_455873.1 Kluyveromyces lactis
GeneID:4344931 Os08g0206600 NP_001061240.1 Oryza sativa
GeneID:4622022 AGOS_AFR213C NP_985760.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005829 Component cytosol
GO:0001950 Component plasma membrane enriched fraction
GO:0003824 Function catalytic activity
GO:0016787 Function hydrolase activity
GO:0003937 Function IMP cyclohydrolase activity
GO:0004643 Function phosphoribosylaminoimidazolecarboxamide formyltransferase activity
GO:0016740 Function transferase activity
GO:0006189 Process 'de novo' IMP biosynthetic process
GO:0006188 Process IMP biosynthetic process
GO:0006164 Process purine nucleotide biosynthetic process
GO:0006417 Process regulation of translation

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

CAA89269   NP_013839   P38009   S54489  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ACB1 ACB1 / ADE17 PCA Tarassov K (2008)
ADE16 ADE16 / ADE17 Affinity Capture-MS Collins SR (2007)
ADE16 ADE16 / ADE17 Affinity Capture-MS Krogan NJ (2006)
ADE16 ADE16 / ADE17 PCA Tarassov K (2008)
ADE16 ADE16 / ADE17 Phenotypic Enhancement Tibbetts AS (2000)
ADE17 ADE17 / ADE17 PCA Tarassov K (2008)
ADE4 ADE17 / ADE4 Dosage Lethality Rebora K (2005)
ALO1 ALO1 / ADE17 PCA Tarassov K (2008)
CAF20 ADE17 / CAF20 PCA Tarassov K (2008)
DCS1 DCS1 / ADE17 PCA Tarassov K (2008)
DEF1 DEF1 / ADE17 PCA Tarassov K (2008)
EFT1 ADE17 / EFT1 PCA Tarassov K (2008)
GIS2 ADE17 / GIS2 PCA Tarassov K (2008)
GLC7 GLC7 / ADE17 Affinity Capture-MS Graumann J (2004)
GSY2 GSY2 / ADE17 PCA Tarassov K (2008)
HCH1 ADE17 / HCH1 PCA Tarassov K (2008)
HUG1 HUG1 / ADE17 PCA Tarassov K (2008)
HYR1 HYR1 / ADE17 PCA Tarassov K (2008)
INO1 INO1 / ADE17 PCA Tarassov K (2008)
N/A N/A / ADE17 Biochemical Activity Ptacek J (2005)
N/A ADE17 / N/A PCA Tarassov K (2008)
PGM2 PGM2 / ADE17 PCA Tarassov K (2008)
PHO13 PHO13 / ADE17 PCA Tarassov K (2008)
PMU1 ADE17 / PMU1 Dosage Rescue Rebora K (2005)
PRP6 PRP6 / ADE17 Affinity Capture-MS Ho Y (2002)
PST2 PST2 / ADE17 PCA Tarassov K (2008)
RSP5 RSP5 / ADE17 Reconstituted Complex Gupta R (2007)
SAP155 SAP155 / ADE17 PCA Tarassov K (2008)
SEM1 SEM1 / ADE17 PCA Tarassov K (2008)
SKI8 SKI8 / ADE17 PCA Tarassov K (2008)
SNC2 ADE17 / SNC2 PCA Tarassov K (2008)
SOL1 SOL1 / ADE17 Affinity Capture-MS Krogan NJ (2006)
SOL1 ADE17 / SOL1 PCA Tarassov K (2008)
STE4 STE4 / ADE17 Affinity Capture-MS Ho Y (2002)
TPK2 TPK2 / ADE17 Biochemical Activity Ptacek J (2005)
TPK3 TPK3 / ADE17 Biochemical Activity Ptacek J (2005)
VMA8 VMA8 / ADE17 PCA Tarassov K (2008)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  2. [ + ] Tarassov K, et al. (2008) "An in vivo map of the yeast protein interactome." Science. 320(5882):1465-1470. PMID:18467557
  3. [ + ] Gupta R, et al. (2007) "Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast." Mol Syst Biol. 3():116. PMID:17551511
  4. [ + ] Collins SR, et al. (2007) "Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae." Mol Cell Proteomics. 6(3):439-450. PMID:17200106
  5. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  6. [ + ] Ptacek J, et al. (2005) "Global analysis of protein phosphorylation in yeast." Nature. 438(7068):679-684. PMID:16319894
  7. [ + ] Rebora K, et al. (2005) "Revisiting purine-histidine cross-pathway regulation in Saccharomyces cerevisiae: a central role for a small molecule." Genetics. 170(1):61-70. PMID:15744050
  8. [ + ] Graumann J, et al. (2004) "Applicability of tandem affinity purification MudPIT to pathway proteomics in yeast." Mol Cell Proteomics. 3(3):226-237. PMID:14660704
  9. [ + ] Ho Y, et al. (2002) "Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry." Nature. 415(6868):180-183. PMID:11805837
  10. [ + ] Tibbetts AS, et al. (2000) "Characterization of two 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase isozymes from Saccharomyces cerevisiae." J Biol Chem. 275(27):20920-20927. PMID:10877846
  11. [ + ] Bowman S, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Nature. 387(6632 Suppl):90-93. PMID:9169872
  12. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441