ADH3 | GeneID:855107 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 855107 Official Symbol ADH3
Locus YMR083W Gene Type protein-coding
Synonyms
Full Name N/A
Description Adh3p
Chromosome N/A
Also Known As Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 58361

ID Symbol Protein Species
GeneID:855107 ADH3 NP_013800.1 Saccharomyces cerevisiae
GeneID:2713728 NCU02476.1 XP_331675.1 Neurospora crassa
GeneID:2894943 ADH4_KLULA XP_455689.1 Kluyveromyces lactis
GeneID:4619006 AGOS_ABL033C NP_982914.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005759 Component mitochondrial matrix
GO:0005739 Component mitochondrion
GO:0005625 Component soluble fraction
GO:0004022 Function alcohol dehydrogenase (NAD) activity
GO:0005488 Function binding
GO:0003824 Function catalytic activity
GO:0046872 Function metal ion binding
GO:0016491 Function oxidoreductase activity
GO:0008270 Function zinc ion binding
GO:0000947 Process amino acid catabolic process to alcohol via Ehrlich pathway
GO:0043284 Process biopolymer biosynthetic process
GO:0006113 Process fermentation
GO:0008152 Process metabolic process
GO:0006116 Process NADH oxidation
GO:0055114 Process oxidation reduction
GO:0006417 Process regulation of translation
GO:0006412 Process translation

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

AAT93007   CAA89229   NP_013800   P07246   S54458  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ADH1 ADH3 / ADH1 Affinity Capture-MS Collins SR (2007)
BNA5 BNA5 / ADH3 Affinity Capture-MS Krogan NJ (2006)
DAD2 DAD2 / ADH3 Affinity Capture-MS Krogan NJ (2006)
DPH1 DPH1 / ADH3 Affinity Capture-MS Krogan NJ (2006)
EFT2 EFT2 / ADH3 Affinity Capture-MS Collins SR (2007)
HSC82 HSC82 / ADH3 Synthetic Growth Defect McClellan AJ (2007)
HSP26 HSP26 / ADH3 Affinity Capture-MS Krogan NJ (2006)
HSP82 HSP82 / ADH3 Synthetic Growth Defect McClellan AJ (2007)
MTF2 MTF2 / ADH3 Affinity Capture-MS Gavin AC (2006)
N/A N/A / ADH3 Affinity Capture-MS Krogan NJ (2006)
NAM7 NAM7 / ADH3 Affinity Capture-MS Gavin AC (2006)
NDI1 ADH3 / NDI1 Phenotypic Enhancement Bakker BM (2000)
PMT1 PMT1 / ADH3 Affinity Capture-MS Krogan NJ (2006)
SAC1 SAC1 / ADH3 Affinity Capture-MS Krogan NJ (2006)
SML1 SML1 / ADH3 Affinity Capture-MS Ho Y (2002)
SMT3 SMT3 / ADH3 Affinity Capture-MS Panse VG (2004)
TIF2 TIF2 / ADH3 Affinity Capture-MS Krogan NJ (2006)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  2. [ + ] McClellan AJ, et al. (2007) "Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches." Cell. 131(1):121-135. PMID:17923092
  3. [ + ] Collins SR, et al. (2007) "Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae." Mol Cell Proteomics. 6(3):439-450. PMID:17200106
  4. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  5. [ + ] Gavin AC, et al. (2006) "Proteome survey reveals modularity of the yeast cell machinery." Nature. 440(7084):631-636. PMID:16429126
  6. [ + ] Bird AJ, et al. (2006) "Repression of ADH1 and ADH3 during zinc deficiency by Zap1-induced intergenic RNA transcripts." EMBO J. 25(24):5726-5734. PMID:17139254
  7. [ + ] Reinders J, et al. (2006) "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." J Proteome Res. 5(7):1543-1554. PMID:16823961
  8. [ + ] Thomson JM, et al. (2005) "Resurrecting ancestral alcohol dehydrogenases from yeast." Nat Genet. 37(6):630-635. PMID:15864308
  9. [ + ] Panse VG, et al. (2004) "A proteome-wide approach identifies sumoylated substrate proteins in yeast." J Biol Chem. 279(40):41346-41351. PMID:15292183
  10. [ + ] Dickinson JR, et al. (2003) "The catabolism of amino acids to long chain and complex alcohols in Saccharomyces cerevisiae." J Biol Chem. 278(10):8028-8034. PMID:12499363
  11. [ + ] Ho Y, et al. (2002) "Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry." Nature. 415(6868):180-183. PMID:11805837
  12. [ + ] de Nobel H, et al. (2001) "Parallel and comparative analysis of the proteome and transcriptome of sorbic acid-stressed Saccharomyces cerevisiae." Yeast. 18(15):1413-1428. PMID:11746603
  13. [ + ] Bakker BM, et al. (2000) "The mitochondrial alcohol dehydrogenase Adh3p is involved in a redox shuttle in Saccharomyces cerevisiae." J Bacteriol. 182(17):4730-4737. PMID:10940011
  14. [ + ] Bowman S, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Nature. 387(6632 Suppl):90-93. PMID:9169872
  15. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  16. [ + ] Pilgrim D, et al. (1987) "Primary structure requirements for correct sorting of the yeast mitochondrial protein ADH III to the yeast mitochondrial matrix space." Mol Cell Biol. 7(1):294-304. PMID:3550419
  17. [ + ] Ganzhorn AJ, et al. (1987) "Kinetic characterization of yeast alcohol dehydrogenases. Amino acid residue 294 and substrate specificity." J Biol Chem. 262(8):3754-3761. PMID:3546317