ABF2 | GeneID:855094 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 855094 Official Symbol ABF2
Locus YMR072W Gene Type protein-coding
Synonyms
Full Name N/A
Description Abf2p
Chromosome N/A
Also Known As Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
Summary N/A

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0000262 Component mitochondrial chromosome
GO:0042645 Component mitochondrial nucleoid
GO:0005739 Component mitochondrion
GO:0005634 Component nucleus
GO:0008301 Function DNA bending activity
GO:0003677 Function DNA binding
GO:0000002 Process mitochondrial genome maintenance
GO:0000001 Process mitochondrion inheritance

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

AJ223169  

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

A41302   AAS56293   CAA11146   CAA88797   NP_013788   Q02486  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ACO1 ABF2 / ACO1 Affinity Capture-Western Kucej M (2008)
ACO1 ABF2 / ACO1 Dosage Rescue Chen XJ (2005)
ACT1 ACT1 / ABF2 Affinity Capture-MS Collins SR (2007)
ACT1 ABF2 / ACT1 Affinity Capture-MS Gavin AC (2006)
ALD4 ABF2 / ALD4 Affinity Capture-Western Kucej M (2008)
ARP9 ARP9 / ABF2 Affinity Capture-MS Collins SR (2007)
ASE1 ABF2 / ASE1 Affinity Capture-MS Collins SR (2007)
CHD1 ABF2 / CHD1 Affinity Capture-MS Krogan NJ (2006)
HAT1 HAT1 / ABF2 Affinity Capture-MS Krogan NJ (2006)
HHF1 HHF1 / ABF2 Affinity Capture-MS Collins SR (2007)
HHF1 ABF2 / HHF1 Affinity Capture-MS Gavin AC (2006)
HHF1 HHF1 / ABF2 Affinity Capture-MS Krogan NJ (2006)
HTA2 HTA2 / ABF2 Affinity Capture-MS Collins SR (2007)
HTA2 HTA2 / ABF2 Affinity Capture-MS Krogan NJ (2006)
HTB2 HTB2 / ABF2 Affinity Capture-MS Collins SR (2007)
HTB2 HTB2 / ABF2 Affinity Capture-MS Krogan NJ (2006)
IDH1 ABF2 / IDH1 Affinity Capture-Western Kucej M (2008)
IDH2 ABF2 / IDH2 Affinity Capture-Western Kucej M (2008)
ILV5 ABF2 / ILV5 Co-fractionation Macierzanka M (2008)
ILV5 ABF2 / ILV5 Dosage Rescue Zelenaya-Troitskaya O (1995)
ILV5 ABF2 / ILV5 Phenotypic Suppression Macierzanka M (2008)
ISW1 ISW1 / ABF2 Affinity Capture-MS Collins SR (2007)
ISW1 ABF2 / ISW1 Affinity Capture-MS Gavin AC (2006)
KGD1 ABF2 / KGD1 Affinity Capture-Western Kucej M (2008)
KGD2 ABF2 / KGD2 Phenotypic Enhancement Kaufman BA (2000)
MLH1 ABF2 / MLH1 PCA Tarassov K (2008)
MOT1 ABF2 / MOT1 Affinity Capture-MS Collins SR (2007)
MOT1 ABF2 / MOT1 Affinity Capture-MS Gavin AC (2006)
N/A N/A / ABF2 Synthetic Lethality Tong AH (2004)
NHP6A ABF2 / NHP6A Affinity Capture-MS Collins SR (2007)
PDR1 ABF2 / PDR1 Affinity Capture-MS Gavin AC (2006)
RNR1 ABF2 / RNR1 Dosage Rescue Lebedeva MA (2007)
RNR1 ABF2 / RNR1 Phenotypic Enhancement Lebedeva MA (2007)
RPS0B ABF2 / RPS0B Affinity Capture-MS Gavin AC (2006)
RSC3 ABF2 / RSC3 Affinity Capture-MS Gavin AC (2006)
RSC6 ABF2 / RSC6 Affinity Capture-MS Gavin AC (2006)
RSC8 RSC8 / ABF2 Affinity Capture-MS Collins SR (2007)
RSC8 ABF2 / RSC8 Affinity Capture-MS Gavin AC (2006)
RVB1 RVB1 / ABF2 Affinity Capture-MS Collins SR (2007)
RVB1 ABF2 / RVB1 Affinity Capture-MS Gavin AC (2006)
SGV1 SGV1 / ABF2 Affinity Capture-MS Krogan NJ (2006)
SHM1 ABF2 / SHM1 Dosage Rescue Kao LR (1996)
SHM1 SHM1 / ABF2 Phenotypic Enhancement Kao LR (1996)
SIN3 SIN3 / ABF2 Affinity Capture-MS Gavin AC (2002)
SIN3 SIN3 / ABF2 Affinity Capture-MS Gavin AC (2006)
SLX8 SLX8 / ABF2 Affinity Capture-MS Krogan NJ (2006)
SNF5 ABF2 / SNF5 Affinity Capture-MS Gavin AC (2006)
SWI3 ABF2 / SWI3 Affinity Capture-MS Gavin AC (2006)
TOP1 ABF2 / TOP1 Affinity Capture-MS Gavin AC (2006)
VIP1 VIP1 / ABF2 Affinity Capture-MS Gavin AC (2006)
VPS1 VPS1 / ABF2 Affinity Capture-MS Collins SR (2007)
VPS1 ABF2 / VPS1 Affinity Capture-MS Gavin AC (2006)
YHM2 ABF2 / YHM2 Dosage Rescue Cho JH (1998)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Kucej M, et al. (2008) "Mitochondrial nucleoids undergo remodeling in response to metabolic cues." J Cell Sci. 121(Pt 11):1861-1868. PMID:18477605
  2. [ + ] Tarassov K, et al. (2008) "An in vivo map of the yeast protein interactome." Science. 320(5882):1465-1470. PMID:18467557
  3. [ + ] Macierzanka M, et al. (2008) "Maintenance and stabilization of mtDNA can be facilitated by the DNA-binding activity of Ilv5p." Biochim Biophys Acta. 1783(1):107-117. PMID:18023287
  4. [ + ] Collins SR, et al. (2007) "Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae." Mol Cell Proteomics. 6(3):439-450. PMID:17200106
  5. [ + ] Lebedeva MA, et al. (2007) "Cell cycle- and ribonucleotide reductase-driven changes in mtDNA copy number influence mtDNA Inheritance without compromising mitochondrial gene expression." Cell Cycle. 6(16):2048-2057. PMID:17721079
  6. [ + ] Gavin AC, et al. (2006) "Proteome survey reveals modularity of the yeast cell machinery." Nature. 440(7084):631-636. PMID:16429126
  7. [ + ] Reinders J, et al. (2006) "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." J Proteome Res. 5(7):1543-1554. PMID:16823961
  8. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  9. [ + ] Chen XJ, et al. (2005) "Aconitase couples metabolic regulation to mitochondrial DNA maintenance." Science. 307(5710):714-717. PMID:15692048
  10. [ + ] Tong AH, et al. (2004) "Global mapping of the yeast genetic interaction network." Science. 303(5659):808-813. PMID:14764870
  11. [ + ] Gavin AC, et al. (2002) "Functional organization of the yeast proteome by systematic analysis of protein complexes." Nature. 415(6868):141-147. PMID:11805826
  12. [ + ] Kaufman BA, et al. (2000) "In organello formaldehyde crosslinking of proteins to mtDNA: identification of bifunctional proteins." Proc Natl Acad Sci U S A. 97(14):7772-7777. PMID:10869431
  13. [ + ] Cho JH, et al. (1998) "A novel DNA-binding protein bound to the mitochondrial inner membrane restores the null mutation of mitochondrial histone Abf2p in Saccharomyces cerevisiae." Mol Cell Biol. 18(10):5712-5723. PMID:9742088
  14. [ + ] Zelenaya-Troitskaya O, et al. (1998) "Functions of the high mobility group protein, Abf2p, in mitochondrial DNA segregation, recombination and copy number in Saccharomyces cerevisiae." Genetics. 148(4):1763-1776. PMID:9581629
  15. [ + ] Bowman S, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Nature. 387(6632 Suppl):90-93. PMID:9169872
  16. [ + ] Kao LR, et al. (1996) "SHM1: a multicopy suppressor of a temperature-sensitive null mutation in the HMG1-like abf2 gene." Yeast. 12(12):1239-1250. PMID:8905928
  17. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  18. [ + ] Zelenaya-Troitskaya O, et al. (1995) "An enzyme in yeast mitochondria that catalyzes a step in branched-chain amino acid biosynthesis also functions in mitochondrial DNA stability." EMBO J. 14(13):3268-3276. PMID:7621838
  19. [ + ] Fisher RP, et al. (1992) "DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator protein." J Biol Chem. 267(5):3358-3367. PMID:1737790