AAC1 | GeneID:855078 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 855078 Official Symbol AAC1
Locus YMR056C Gene Type protein-coding
Full Name N/A
Description Aac1p
Chromosome N/A
Also Known As Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 111098

ID Symbol Protein Species
GeneID:820005 AAC1 NP_187470.1 Arabidopsis thaliana
GeneID:831193 AAC2 NP_001031876.1 Arabidopsis thaliana
GeneID:855078 AAC1 NP_013772.1 Saccharomyces cerevisiae
GeneID:4330539 Os02g0718900 NP_001047941.1 Oryza sativa

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0016021 Component integral to membrane
GO:0016020 Component membrane
GO:0005743 Component mitochondrial inner membrane
GO:0005739 Component mitochondrion
GO:0005471 Function ATP:ADP antiporter activity
GO:0005488 Function binding
GO:0005215 Function transporter activity
GO:0009060 Process aerobic respiration
GO:0006783 Process heme biosynthetic process
GO:0006839 Process mitochondrial transport
GO:0006810 Process transport

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

A24849   AAA97486   CAA89766   NP_013772   P04710  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ATG12 ATG12 / AAC1 Affinity Capture-MS Ho Y (2002)
BIO5 BIO5 / AAC1 Two-hybrid Miller JP (2005)
LSM1 LSM1 / AAC1 Two-hybrid Fromont-Racine M (2000)
PET9 AAC1 / PET9 Phenotypic Enhancement Pereira C (2007)
PET9 AAC1 / PET9 Synthetic Lethality Fontanesi F (2004)
RAD3 RAD3 / AAC1 Affinity Capture-MS Ho Y (2002)
SAL1 SAL1 / AAC1 Phenotypic Enhancement Kucejova B (2008)
SKP1 SKP1 / AAC1 Affinity Capture-MS Tagwerker C (2006)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Azuma M, et al. (2008) "Adenine nucleotide translocator transports haem precursors into mitochondria." PLoS ONE. 3(8):e3070. PMID:18728780
  2. [ + ] Kucejova B, et al. (2008) "Pleiotropic effects of the yeast Sal1 and Aac2 carriers on mitochondrial function via an activity distinct from adenine nucleotide transport." Mol Genet Genomics. 280(1):25-39. PMID:18431598
  3. [ + ] Iwahashi A, et al. (2008) "Functionally important conserved length of C-terminal regions of yeast and bovine ADP/ATP carriers, identified by deletion mutants studies, and water accessibility of the amino acids at the C-terminal region of the yeast carrier." Mitochondrion. 8(2):196-204. PMID:18313366
  4. [ + ] Pereira C, et al. (2007) "ADP/ATP carrier is required for mitochondrial outer membrane permeabilization and cytochrome c release in yeast apoptosis." Mol Microbiol. 66(3):571-582. PMID:17822411
  5. [ + ] Tagwerker C, et al. (2006) "A tandem affinity tag for two-step purification under fully denaturing conditions: application in ubiquitin profiling and protein complex identification combined with in vivocross-linking." Mol Cell Proteomics. 5(4):737-748. PMID:16432255
  6. [ + ] Reinders J, et al. (2006) "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." J Proteome Res. 5(7):1543-1554. PMID:16823961
  7. [ + ] Miller JP, et al. (2005) "Large-scale identification of yeast integral membrane protein interactions." Proc Natl Acad Sci U S A. 102(34):12123-12128. PMID:16093310
  8. [ + ] Vergnolle MA, et al. (2005) "A cryptic matrix targeting signal of the yeast ADP/ATP carrier normally inserted by the TIM22 complex is recognized by the TIM23 machinery." Biochem J. 385(Pt 1):173-180. PMID:15320873
  9. [ + ] Fontanesi F, et al. (2004) "Mutations in AAC2, equivalent to human adPEO-associated ANT1 mutations, lead to defective oxidative phosphorylation in Saccharomyces cerevisiae and affect mitochondrial DNA stability." Hum Mol Genet. 13(9):923-934. PMID:15016764
  10. [ + ] Ho Y, et al. (2002) "Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry." Nature. 415(6868):180-183. PMID:11805837
  11. [ + ] Fromont-Racine M, et al. (2000) "Genome-wide protein interaction screens reveal functional networks involving Sm-like proteins." Yeast. 17(2):95-110. PMID:10900456
  12. [ + ] Bowman S, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Nature. 387(6632 Suppl):90-93. PMID:9169872
  13. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  14. [ + ] Gawaz M, et al. (1990) "Structure-function studies of adenine nucleotide transport in mitochondria. II. Biochemical analysis of distinct AAC1 and AAC2 proteins in yeast." J Biol Chem. 265(24):14202-14208. PMID:2167309