ADE2 | GeneID:854295 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 854295 Official Symbol ADE2
Locus YOR128C Gene Type protein-coding
Full Name N/A
Description Ade2p
Chromosome N/A
Also Known As Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 6956

ID Symbol Protein Species
GeneID:818346 AT2G37690 NP_181305.2 Arabidopsis thaliana
GeneID:854295 ADE2 NP_014771.1 Saccharomyces cerevisiae
GeneID:2538734 ade6 NP_588141.1 Schizosaccharomyces pombe
GeneID:2894665 KLLA0E02640g XP_454067.1 Kluyveromyces lactis
GeneID:4327345 Os01g0199900 NP_001042312.1 Oryza sativa
GeneID:4619744 AGOS_ACR210C NP_983612.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0005524 Function ATP binding
GO:0016831 Function carboxy-lyase activity
GO:0003824 Function catalytic activity
GO:0016829 Function lyase activity
GO:0000166 Function nucleotide binding
GO:0004638 Function phosphoribosylaminoimidazole carboxylase activity
GO:0006725 Process cellular aromatic compound metabolic process
GO:0006189 Process 'de novo' IMP biosynthetic process
GO:0009117 Process nucleotide metabolic process
GO:0006730 Process one-carbon compound metabolic process
GO:0006144 Process purine base metabolic process
GO:0006164 Process purine nucleotide biosynthetic process

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

AAA34401   CAA62125   CAA64047   CAA99327   DEBYP   NP_014771   P21264  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ADE13 ADE13 / ADE2 Synthetic Rescue Zekhnov AM (2000)
ADE2 ADE2 / ADE2 Two-hybrid Uetz P (2000)
ADE4 ADE2 / ADE4 Phenotypic Suppression Zekhnov AM (1998)
ADE5,7 ADE2 / ADE5,7 Phenotypic Suppression Zekhnov AM (1998)
ADE6 ADE2 / ADE6 Phenotypic Suppression Zekhnov AM (1998)
ADE8 ADE2 / ADE8 Phenotypic Suppression Zekhnov AM (1998)
DCP1 ADE2 / DCP1 Synthetic Rescue Kofuji S (2006)
EAF5 EAF5 / ADE2 Two-hybrid Ito T (2001)
HPT1 ADE2 / HPT1 Phenotypic Suppression Breton A (2008)
HSC82 HSC82 / ADE2 Synthetic Growth Defect McClellan AJ (2007)
HSP82 HSP82 / ADE2 Synthetic Growth Defect McClellan AJ (2007)
LYS5 LYS5 / ADE2 Two-hybrid Ito T (2001)
RAD18 ADE2 / RAD18 Two-hybrid Uetz P (2000)
RPN3 RPN3 / ADE2 Affinity Capture-MS Krogan NJ (2006)
SED4 ADE2 / SED4 Two-hybrid Uetz P (2000)
SOH1 SOH1 / ADE2 Two-hybrid Ito T (2001)
SRP54 SRP54 / ADE2 Two-hybrid Ito T (2001)
SUP11 SUP11 / ADE2 Phenotypic Suppression Theis JF (2007)
TAF9 TAF9 / ADE2 Two-hybrid Ito T (2001)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Breton A, et al. (2008) "Lethal accumulation of guanylic nucleotides in Saccharomyces cerevisiae HPT1-deregulated mutants." Genetics. 178(2):815-824. PMID:18245832
  2. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  3. [ + ] McClellan AJ, et al. (2007) "Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches." Cell. 131(1):121-135. PMID:17923092
  4. [ + ] Theis JF, et al. (2007) "Identification of mutations that decrease the stability of a fragment of Saccharomyces cerevisiae chromosome III lacking efficient replicators." Genetics. 177(3):1445-1458. PMID:17720931
  5. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  6. [ + ] Kofuji S, et al. (2006) "The decapping enzyme Dcp1 participates in translation termination through its interaction with the release factor eRF3 in budding yeast." Biochem Biophys Res Commun. 344(2):547-553. PMID:16630557
  7. [ + ] Huh WK, et al. (2003) "Global analysis of protein localization in budding yeast." Nature. 425(6959):686-691. PMID:14562095
  8. [ + ] Ito T, et al. (2001) "A comprehensive two-hybrid analysis to explore the yeast protein interactome." Proc Natl Acad Sci U S A. 98(8):4569-4574. PMID:11283351
  9. [ + ] Uetz P, et al. (2000) "A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae." Nature. 403(6770):623-627. PMID:10688190
  10. [ + ] Zekhnov AM, et al. (2000) "[The phenomenon of predetermination of the cytoplasm upon interaction between alleles of the ADE2 and ADE13 in the yeast Saccharomyces cerevisiae]" Genetika. 36(4):470-481. PMID:10822807
  11. [ + ] Zekhnov AM, et al. (1998) "[New phenotypic manifestation of the ad2 mutation in Saccharomyces cerevisiae yeast--the inability to grow on a synthetic medium with glycerol and hypoxanthine]" Genetika. 34(2):190-197. PMID:9589850
  12. [ + ] Dujon B, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Nature. 387(6632 Suppl):98-102. PMID:9169874
  13. [ + ] Ugolini S, et al. (1996) "The red/white colony color assay in the yeast Saccharomyces cerevisiae: epistatic growth advantage of white ade8-18, ade2 cells over red ade2 cells." Curr Genet. 30(6):485-492. PMID:8939809
  14. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  15. [ + ] Silver JM, et al. (1969) "Functional blocks of the ad-1 and ad-2 mutants of Saccharomyces cerevisiae." Biochem Biophys Res Commun. 34(3):301-305. PMID:5767024