ADH1 | GeneID:854068 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 854068 Official Symbol ADH1
Locus YOL086C Gene Type protein-coding
Synonyms ADC1
Full Name N/A
Description Adh1p
Chromosome N/A
Also Known As Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 113665

ID Symbol Protein Species
GeneID:854068 ADH1 NP_014555.1 Saccharomyces cerevisiae
GeneID:855349 ADH2 NP_014032.1 Saccharomyces cerevisiae
GeneID:2894942 ADH2_KLULA XP_455899.1 Kluyveromyces lactis
GeneID:2895056 ADH1_KLULA XP_456023.1 Kluyveromyces lactis
GeneID:4618556 AGOS_AAR084W NP_982625.1 Eremothecium gossypii
GeneID:4621094 AGOS_AER032W NP_984892.1 Eremothecium gossypii

Antibodies

[ - ] Monoclonal and Polyclonal Antibodies

No. Provider Product No. Description
1 abcam ab34680 Alcohol Dehydrogenase antibody (ab34680); Rabbit polyclonal to Alcohol Dehydrogenase
2 abcam ab20994 Alcohol Dehydrogenase antibody (ab20994); Rabbit polyclonal to Alcohol Dehydrogenase

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0005829 Component cytosol
GO:0001950 Component plasma membrane enriched fraction
GO:0004022 Function alcohol dehydrogenase (NAD) activity
GO:0005488 Function binding
GO:0003824 Function catalytic activity
GO:0046872 Function metal ion binding
GO:0019170 Function methylglyoxal reductase (NADH-dependent) activity
GO:0016491 Function oxidoreductase activity
GO:0008270 Function zinc ion binding
GO:0000947 Process amino acid catabolic process to alcohol via Ehrlich pathway
GO:0043284 Process biopolymer biosynthetic process
GO:0043458 Process ethanol biosynthetic process during fermentation
GO:0006113 Process fermentation
GO:0008152 Process metabolic process
GO:0006116 Process NADH oxidation
GO:0055114 Process oxidation reduction
GO:0006417 Process regulation of translation
GO:0006412 Process translation

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

CAA58193   CAA99098   DEBYA   NP_014555  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ADH2 ADH2 / ADH1 Affinity Capture-MS Collins SR (2007)
ADH2 ADH1 / ADH2 Phenotypic Enhancement Kusano M (1998)
ADH3 ADH3 / ADH1 Affinity Capture-MS Collins SR (2007)
AOS1 AOS1 / ADH1 Affinity Capture-MS Gavin AC (2002)
ATG18 ATG18 / ADH1 Affinity Capture-MS Gavin AC (2002)
BCH1 BCH1 / ADH1 Affinity Capture-MS Gavin AC (2006)
BUD7 BUD7 / ADH1 Affinity Capture-MS Gavin AC (2006)
CDC40 CDC40 / ADH1 Phenotypic Suppression Kaplan Y (2007)
CHS6 CHS6 / ADH1 Affinity Capture-MS Gavin AC (2006)
ECM1 ECM1 / ADH1 Affinity Capture-MS Gavin AC (2002)
EFT1 ADH1 / EFT1 Affinity Capture-MS Collins SR (2007)
EFT2 EFT2 / ADH1 Affinity Capture-MS Collins SR (2007)
ESA1 ESA1 / ADH1 Affinity Capture-MS Gavin AC (2002)
FAR11 FAR11 / ADH1 Affinity Capture-MS Gavin AC (2002)
FBA1 FBA1 / ADH1 Affinity Capture-MS Collins SR (2007)
FTH1 FTH1 / ADH1 Affinity Capture-MS Gavin AC (2002)
FUN19 FUN19 / ADH1 Affinity Capture-MS Gavin AC (2002)
GCN5 GCN5 / ADH1 Affinity Capture-MS Graumann J (2004)
GRD19 GRD19 / ADH1 Two-hybrid Vollert CS (2004)
GRH1 GRH1 / ADH1 Affinity Capture-MS Gavin AC (2006)
HPR5 HPR5 / ADH1 Two-hybrid Chiolo I (2005)
HSC82 HSC82 / ADH1 Affinity Capture-MS Collins SR (2007)
HSC82 HSC82 / ADH1 Synthetic Growth Defect McClellan AJ (2007)
HSP82 HSP82 / ADH1 Synthetic Growth Defect McClellan AJ (2007)
ISW2 ISW2 / ADH1 Affinity Capture-MS Gavin AC (2002)
LEU1 LEU1 / ADH1 Affinity Capture-MS Gavin AC (2002)
MED7 MED7 / ADH1 Affinity Capture-MS Gavin AC (2002)
MIA40 MIA40 / ADH1 Affinity Capture-MS Hazbun TR (2003)
MOT1 MOT1 / ADH1 Affinity Capture-MS Gavin AC (2002)
MUC1 MUC1 / ADH1 Phenotypic Suppression Palecek SP (2000)
MYO4 MYO4 / ADH1 Affinity Capture-MS Gavin AC (2002)
N/A N/A / ADH1 Affinity Capture-MS Gavin AC (2002)
NOB1 NOB1 / ADH1 Affinity Capture-MS Gavin AC (2002)
PDC1 PDC1 / ADH1 Affinity Capture-MS Collins SR (2007)
PGI1 PGI1 / ADH1 Affinity Capture-MS Collins SR (2007)
PGK1 PGK1 / ADH1 Affinity Capture-MS Collins SR (2007)
PRC1 PRC1 / ADH1 Affinity Capture-MS Gavin AC (2006)
PRR1 PRR1 / ADH1 Biochemical Activity Ptacek J (2005)
RAD16 RAD16 / ADH1 Affinity Capture-MS Gavin AC (2002)
SEC1 SEC1 / ADH1 Affinity Capture-MS Gavin AC (2002)
SEC39 SEC39 / ADH1 Affinity Capture-MS Gavin AC (2006)
SEC7 SEC7 / ADH1 Affinity Capture-MS Gavin AC (2002)
SIR2 SIR2 / ADH1 Affinity Capture-MS Gavin AC (2002)
SMT3 SMT3 / ADH1 Affinity Capture-MS Hannich JT (2005)
SMT3 SMT3 / ADH1 Affinity Capture-MS Panse VG (2004)
TIP20 TIP20 / ADH1 Affinity Capture-MS Gavin AC (2006)
TPI1 TPI1 / ADH1 Affinity Capture-MS Collins SR (2007)
UBP14 UBP14 / ADH1 Affinity Capture-MS Gavin AC (2002)
UFE1 UFE1 / ADH1 Affinity Capture-MS Gavin AC (2006)
USE1 USE1 / ADH1 Affinity Capture-MS Gavin AC (2006)
YEF3 YEF3 / ADH1 Affinity Capture-MS Collins SR (2007)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Markossian KA, et al. (2008) "Mechanism of thermal aggregation of yeast alcohol dehydrogenase I: role of intramolecular chaperone." Biochim Biophys Acta. 1784(9):1286-1293. PMID:18515108
  2. [ + ] Laadan B, et al. (2008) "Identification of an NADH-dependent 5-hydroxymethylfurfural-reducing alcohol dehydrogenase in Saccharomyces cerevisiae." Yeast. 25(3):191-198. PMID:18302314
  3. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  4. [ + ] Men L, et al. (2007) "The oxidation of yeast alcohol dehydrogenase-1 by hydrogen peroxide in vitro." J Proteome Res. 6(1):216-225. PMID:17203966
  5. [ + ] Kaplan Y, et al. (2007) "A role for the yeast cell cycle/splicing factor Cdc40 in the G1/S transition." Curr Genet. 51(2):123-140. PMID:17171376
  6. [ + ] Collins SR, et al. (2007) "Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae." Mol Cell Proteomics. 6(3):439-450. PMID:17200106
  7. [ + ] Reverter-Branchat G, et al. (2007) "Chronological and replicative life-span extension in Saccharomyces cerevisiae by increased dosage of alcohol dehydrogenase 1." Microbiology. 153(Pt 11):3667-3676. PMID:17975074
  8. [ + ] McClellan AJ, et al. (2007) "Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches." Cell. 131(1):121-135. PMID:17923092
  9. [ + ] Bird AJ, et al. (2006) "Repression of ADH1 and ADH3 during zinc deficiency by Zap1-induced intergenic RNA transcripts." EMBO J. 25(24):5726-5734. PMID:17139254
  10. [ + ] Gavin AC, et al. (2006) "Proteome survey reveals modularity of the yeast cell machinery." Nature. 440(7084):631-636. PMID:16429126
  11. [ + ] Hannich JT, et al. (2005) "Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae." J Biol Chem. 280(6):4102-4110. PMID:15590687
  12. [ + ] Calvo O, et al. (2005) "The transcriptional coactivator PC4/Sub1 has multiple functions in RNA polymerase II transcription." EMBO J. 24(5):1009-1020. PMID:15692559
  13. [ + ] Muratani M, et al. (2005) "The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing." Cell. 120(6):887-899. PMID:15797387
  14. [ + ] Thomson JM, et al. (2005) "Resurrecting ancestral alcohol dehydrogenases from yeast." Nat Genet. 37(6):630-635. PMID:15864308
  15. [ + ] Chiolo I, et al. (2005) "Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation." Mol Cell Biol. 25(13):5738-5751. PMID:15964827
  16. [ + ] Ptacek J, et al. (2005) "Global analysis of protein phosphorylation in yeast." Nature. 438(7068):679-684. PMID:16319894
  17. [ + ] Smith MG, et al. (2004) "Microbial synergy via an ethanol-triggered pathway." Mol Cell Biol. 24(9):3874-3884. PMID:15082781
  18. [ + ] Panse VG, et al. (2004) "A proteome-wide approach identifies sumoylated substrate proteins in yeast." J Biol Chem. 279(40):41346-41351. PMID:15292183
  19. [ + ] Vollert CS, et al. (2004) "The phox homology (PX) domain protein interaction network in yeast." Mol Cell Proteomics. 3(11):1053-1064. PMID:15263065
  20. [ + ] Graumann J, et al. (2004) "Applicability of tandem affinity purification MudPIT to pathway proteomics in yeast." Mol Cell Proteomics. 3(3):226-237. PMID:14660704
  21. [ + ] Hazbun TR, et al. (2003) "Assigning function to yeast proteins by integration of technologies." Mol Cell. 12(6):1353-1365. PMID:14690591
  22. [ + ] Chen CN, et al. (2003) "Associating protein activities with their genes: rapid identification of a gene encoding a methylglyoxal reductase in the yeast Saccharomyces cerevisiae." Yeast. 20(6):545-554. PMID:12722185
  23. [ + ] Dickinson JR, et al. (2003) "The catabolism of amino acids to long chain and complex alcohols in Saccharomyces cerevisiae." J Biol Chem. 278(10):8028-8034. PMID:12499363
  24. [ + ] Krogan NJ, et al. (2002) "RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach." Mol Cell Biol. 22(20):6979-6992. PMID:12242279
  25. [ + ] Gavin AC, et al. (2002) "Functional organization of the yeast proteome by systematic analysis of protein complexes." Nature. 415(6868):141-147. PMID:11805826
  26. [ + ] Palecek SP, et al. (2000) "Genetic analysis reveals that FLO11 upregulation and cell polarization independently regulate invasive growth in Saccharomyces cerevisiae." Genetics. 156(3):1005-1023. PMID:11063681
  27. [ + ] Kusano M, et al. (1998) "Hemiacetal dehydrogenation activity of alcohol dehydrogenases in Saccharomyces cerevisiae." Biosci Biotechnol Biochem. 62(10):1956-1961. PMID:9836432
  28. [ + ] Dujon B, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Nature. 387(6632 Suppl):98-102. PMID:9169874
  29. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  30. [ + ] Ganzhorn AJ, et al. (1987) "Kinetic characterization of yeast alcohol dehydrogenases. Amino acid residue 294 and substrate specificity." J Biol Chem. 262(8):3754-3761. PMID:3546317
  31. [ + ] Williamson VM, et al. (1980) "Isolation of the structural gene for alcohol dehydrogenase by genetic complementation in yeast." Nature. 283(5743):214-216. PMID:6985717