AAT1 | GeneID:853755 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 853755 Official Symbol AAT1
Locus YKL106W Gene Type protein-coding
Full Name N/A
Description Aat1p
Chromosome N/A
Also Known As Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 56231

ID Symbol Protein Species
GeneID:853755 AAT1 NP_012816.1 Saccharomyces cerevisiae
GeneID:2895811 KLLA0F13640g XP_455694.1 Kluyveromyces lactis
GeneID:4618992 AGOS_ABL038W NP_982909.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005759 Component mitochondrial matrix
GO:0005739 Component mitochondrion
GO:0003824 Function catalytic activity
GO:0004069 Function L-aspartate:2-oxoglutarate aminotransferase activity
GO:0030170 Function pyridoxal phosphate binding
GO:0008483 Function transaminase activity
GO:0016740 Function transferase activity
GO:0016769 Function transferase activity, transferring nitrogenous groups
GO:0019266 Process asparagine biosynthetic process from oxaloacetate
GO:0006532 Process aspartate biosynthetic process
GO:0006533 Process aspartate catabolic process
GO:0009058 Process biosynthetic process
GO:0006520 Process cellular amino acid metabolic process
GO:0001300 Process chronological cell aging
GO:0001302 Process replicative cell aging
GO:0042254 Process ribosome biogenesis
GO:0016072 Process rRNA metabolic process

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

CAA50451   CAA81946   NP_012816   Q01802   S37933  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
CDC25 CDC25 / AAT1 Phenotypic Suppression Easlon E (2008)
CYT1 AAT1 / CYT1 Phenotypic Suppression Easlon E (2008)
FOB1 AAT1 / FOB1 Phenotypic Suppression Easlon E (2008)
GUT2 GUT2 / AAT1 Phenotypic Suppression Easlon E (2008)
HAP4 HAP4 / AAT1 Phenotypic Suppression Easlon E (2008)
HST1 AAT1 / HST1 Phenotypic Suppression Easlon E (2008)
HST2 AAT1 / HST2 Phenotypic Suppression Easlon E (2008)
LAT1 LAT1 / AAT1 Phenotypic Suppression Easlon E (2008)
MDH1 MDH1 / AAT1 Phenotypic Enhancement Easlon E (2008)
SIR2 AAT1 / SIR2 Phenotypic Suppression Easlon E (2008)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  2. [ + ] Easlon E, et al. (2008) "The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast." Genes Dev. 22(7):931-944. PMID:18381895
  3. [ + ] Reinders J, et al. (2006) "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." J Proteome Res. 5(7):1543-1554. PMID:16823961
  4. [ + ] Sickmann A, et al. (2003) "The proteome of Saccharomyces cerevisiae mitochondria." Proc Natl Acad Sci U S A. 100(23):13207-13212. PMID:14576278
  5. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  6. [ + ] Dujon B, et al. (1994) "Complete DNA sequence of yeast chromosome XI." Nature. 369(6479):371-378. PMID:8196765
  7. [ + ] Morin PJ, et al. (1992) "AAT1, a gene encoding a mitochondrial aspartate aminotransferase in Saccharomyces cerevisiae." Biochim Biophys Acta. 1171(2):211-214. PMID:1482685