ABF1 | GeneID:853748 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 853748 Official Symbol ABF1
Locus YKL112W Gene Type protein-coding
Synonyms BAF1; OBF1; REB2; SBF1
Full Name N/A
Description Abf1p
Chromosome N/A
Also Known As DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 39535

ID Symbol Protein Species
GeneID:853748 ABF1 NP_012810.1 Saccharomyces cerevisiae
GeneID:2894945 BAF1_KLULA XP_455214.1 Kluyveromyces lactis
GeneID:4618979 AGOS_ABL051W NP_982896.1 Eremothecium gossypii

Antibodies

[ - ] Monoclonal and Polyclonal Antibodies

No. Provider Product No. Description
1 abcam ab21760 ABF1 antibody (ab21760); Mouse polyclonal to ABF1

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0000790 Component nuclear chromatin
GO:0000113 Component nucleotide-excision repair factor 4 complex
GO:0005634 Component nucleus
GO:0003682 Function chromatin binding
GO:0008301 Function DNA bending activity
GO:0003677 Function DNA binding
GO:0003688 Function DNA replication origin binding
GO:0046872 Function metal ion binding
GO:0043565 Function sequence-specific DNA binding
GO:0016563 Function transcription activator activity
GO:0016564 Function transcription repressor activity
GO:0008270 Function zinc ion binding
GO:0006338 Process chromatin remodeling
GO:0030466 Process chromatin silencing at silent mating-type cassette
GO:0006260 Process DNA replication
GO:0000122 Process negative regulation of transcription from RNA polymerase II promoter
GO:0000715 Process nucleotide-excision repair, DNA damage recognition
GO:0045944 Process positive regulation of transcription from RNA polymerase II promoter
GO:0006355 Process regulation of transcription, DNA-dependent
GO:0006350 Process transcription

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
CDC2 ABF1 / CDC2 Synthetic Lethality Chanet R (2003)
CDC6 ABF1 / CDC6 Reconstituted Complex Feng L (1998)
CKA1 CKA1 / ABF1 Biochemical Activity Upton T (1995)
CKA1 ABF1 / CKA1 Reconstituted Complex Upton T (1995)
CKA1 CKA1 / ABF1 Reconstituted Complex Upton T (1995)
CKA2 ABF1 / CKA2 Reconstituted Complex Upton T (1995)
CKB1 ABF1 / CKB1 Reconstituted Complex Upton T (1995)
CKB2 ABF1 / CKB2 Reconstituted Complex Upton T (1995)
DOT1 ABF1 / DOT1 Phenotypic Enhancement Collins SR (2007)
GIM3 GIM3 / ABF1 Phenotypic Suppression Collins SR (2007)
GLC7 GLC7 / ABF1 Affinity Capture-MS Graumann J (2004)
HIR2 HIR2 / ABF1 Phenotypic Suppression Collins SR (2007)
MAD3 ABF1 / MAD3 Phenotypic Enhancement Collins SR (2007)
MCK1 MCK1 / ABF1 Phenotypic Enhancement Collins SR (2007)
MNN10 ABF1 / MNN10 Phenotypic Enhancement Collins SR (2007)
MRE11 MRE11 / ABF1 Phenotypic Enhancement Collins SR (2007)
PEX22 ABF1 / PEX22 Phenotypic Enhancement Collins SR (2007)
PSE1 ABF1 / PSE1 Dosage Rescue Loch CM (2004)
PSE1 ABF1 / PSE1 Reconstituted Complex Loch CM (2004)
RAD16 RAD16 / ABF1 Co-fractionation Reed SH (1999)
RAD16 ABF1 / RAD16 Phenotypic Suppression Collins SR (2007)
RAD7 RAD7 / ABF1 Co-fractionation Reed SH (1999)
RVS161 ABF1 / RVS161 Phenotypic Enhancement Collins SR (2007)
SET7 ABF1 / SET7 Phenotypic Enhancement Collins SR (2007)
SMT3 SMT3 / ABF1 Affinity Capture-MS Hannich JT (2005)
SPT3 ABF1 / SPT3 Phenotypic Enhancement Collins SR (2007)
SRL2 SRL2 / ABF1 Affinity Capture-MS Krogan NJ (2006)
SSF1 ABF1 / SSF1 Phenotypic Enhancement Collins SR (2007)
TAT2 ABF1 / TAT2 Dosage Rescue Shin YH (1996)
TRP1 ABF1 / TRP1 Dosage Rescue So IS (1997)
UBP3 ABF1 / UBP3 Phenotypic Enhancement Collins SR (2007)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Yarragudi A, et al. (2007) "Genome-wide analysis of transcriptional dependence and probable target sites for Abf1 and Rap1 in Saccharomyces cerevisiae." Nucleic Acids Res. 35(1):193-202. PMID:17158163
  2. [ + ] Collins SR, et al. (2007) "Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map." Nature. 446(7137):806-810. PMID:17314980
  3. [ + ] Aranda C, et al. (2006) "Gcn5p contributes to the bidirectional character of the UGA3-GLT1 yeast promoter." Biochem Biophys Res Commun. 348(3):989-996. PMID:16904075
  4. [ + ] Kawasaki Y, et al. (2006) "Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro." Genes Cells. 11(7):745-756. PMID:16824194
  5. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  6. [ + ] Hannich JT, et al. (2005) "Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae." J Biol Chem. 280(6):4102-4110. PMID:15590687
  7. [ + ] Beinoraviciute-Kellner R, et al. (2005) "In vitro selection of DNA binding sites for ABF1 protein from Saccharomyces cerevisiae." FEBS Lett. 579(20):4535-4540. PMID:16083878
  8. [ + ] Yu S, et al. (2004) "The yeast Rad7/Rad16/Abf1 complex generates superhelical torsion in DNA that is required for nucleotide excision repair." DNA Repair (Amst). 3(3):277-287. PMID:15177043
  9. [ + ] Loch CM, et al. (2004) "Functional and physical interactions between autonomously replicating sequence-binding factor 1 and the nuclear transport machinery." Traffic. 5(12):925-935. PMID:15522095
  10. [ + ] Yarragudi A, et al. (2004) "Comparison of ABF1 and RAP1 in chromatin opening and transactivator potentiation in the budding yeast Saccharomyces cerevisiae." Mol Cell Biol. 24(20):9152-9164. PMID:15456886
  11. [ + ] Miyake T, et al. (2004) "Genome-wide analysis of ARS (autonomously replicating sequence) binding factor 1 (Abf1p)-mediated transcriptional regulation in Saccharomyces cerevisiae." J Biol Chem. 279(33):34865-34872. PMID:15192094
  12. [ + ] Graumann J, et al. (2004) "Applicability of tandem affinity purification MudPIT to pathway proteomics in yeast." Mol Cell Proteomics. 3(3):226-237. PMID:14660704
  13. [ + ] Chanet R, et al. (2003) "Characterization of mutations that are synthetic lethal with pol3-13, a mutated allele of DNA polymerase delta in Saccharomyces cerevisiae." Curr Genet. 43(5):337-350. PMID:12759774
  14. [ + ] Miyake T, et al. (2002) "Identification of a multifunctional domain in autonomously replicating sequence-binding factor 1 required for transcriptional activation, DNA replication, and gene silencing." Mol Cell Biol. 22(2):505-516. PMID:11756546
  15. [ + ] Lascaris RF, et al. (2000) "Different roles for abf1p and a T-rich promoter element in nucleosome organization of the yeast RPS28A gene." Nucleic Acids Res. 28(6):1390-1396. PMID:10684934
  16. [ + ] Reed SH, et al. (1999) "Yeast autonomously replicating sequence binding factor is involved in nucleotide excision repair." Genes Dev. 13(23):3052-3058. PMID:10601031
  17. [ + ] Feng L, et al. (1998) "Saccharomyces cerevisiae Cdc6 stimulates Abf1 DNA binding activity." J Biol Chem. 273(3):1298-1302. PMID:9430660
  18. [ + ] So IS, et al. (1997) "Molecular cloning and characterization of the Saccharomyces cerevisiae SAB1 gene that suppresses a temperature-sensitive phenotype of the ARS-binding factor 1 mutant." Mol Cells. 7(4):532-536. PMID:9339899
  19. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  20. [ + ] Shin YH, et al. (1996) "Isolation and characterization of Saccharomyces cerevisiae SAB2, a suppressor gene for temperature-sensitive phenotype of ARS-binding factor 1 mutant." Biochem Mol Biol Int. 40(5):915-921. PMID:8955880
  21. [ + ] Upton T, et al. (1995) "ABF1 Ser-720 is a predominant phosphorylation site for casein kinase II of Saccharomyces cerevisiae." J Biol Chem. 270(27):16153-16159. PMID:7608180
  22. [ + ] Loo S, et al. (1995) "Roles of ABF1, NPL3, and YCL54 in silencing in Saccharomyces cerevisiae." Genetics. 141(3):889-902. PMID:8582634
  23. [ + ] McBroom LD, et al. (1994) "DNA bending by Saccharomyces cerevisiae ABF1 and its proteolytic fragments." J Biol Chem. 269(23):16461-16468. PMID:8206955
  24. [ + ] Dujon B, et al. (1994) "Complete DNA sequence of yeast chromosome XI." Nature. 369(6479):371-378. PMID:8196765
  25. [ + ] Buchman AR, et al. (1988) "Two DNA-binding factors recognize specific sequences at silencers, upstream activating sequences, autonomously replicating sequences, and telomeres in Saccharomyces cerevisiae." Mol Cell Biol. 8(1):210-225. PMID:3275867