ADD66 | GeneID:853629 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 853629 Official Symbol ADD66
Locus YKL206C Gene Type protein-coding
Synonyms PBA2; POC2
Full Name N/A
Description Add66p
Chromosome N/A
Also Known As Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 39499

ID Symbol Protein Species
GeneID:853629 ADD66 NP_012716.1 Saccharomyces cerevisiae
GeneID:2897038 KLLA0B14102g XP_452159.1 Kluyveromyces lactis
GeneID:4622247 AGOS_AFR427W NP_985974.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0005829 Component cytosol
GO:0003674 Function molecular_function
GO:0030433 Process ER-associated protein catabolic process
GO:0043248 Process proteasome assembly

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

AAS56720   CAA82051   NP_012716   P36040   S38044  

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Collins SR, et al. (2007) "Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae." Mol Cell Proteomics. 6(3):439-450. PMID:17200106
  2. [ + ] Le Tallec B, et al. (2007) "20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals." Mol Cell. 27(4):660-674. PMID:17707236
  3. [ + ] Scott CM, et al. (2007) "ADD66, a gene involved in the endoplasmic reticulum-associated degradation of alpha-1-antitrypsin-Z in yeast, facilitates proteasome activity and assembly." Mol Biol Cell. 18(10):3776-3787. PMID:17634286
  4. [ + ] Li X, et al. (2007) "beta-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint." EMBO J. 26(9):2339-2349. PMID:17431397
  5. [ + ] Pan X, et al. (2006) "A DNA integrity network in the yeast Saccharomyces cerevisiae." Cell. 124(5):1069-1081. PMID:16487579
  6. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  7. [ + ] Ptacek J, et al. (2005) "Global analysis of protein phosphorylation in yeast." Nature. 438(7068):679-684. PMID:16319894
  8. [ + ] Huh WK, et al. (2003) "Global analysis of protein localization in budding yeast." Nature. 425(6959):686-691. PMID:14562095
  9. [ + ] Palmer EA, et al. (2003) "Differential requirements of novel A1PiZ degradation deficient (ADD) genes in ER-associated protein degradation." J Cell Sci. 116(Pt 11):2361-2373. PMID:12711700
  10. [ + ] Ho Y, et al. (2002) "Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry." Nature. 415(6868):180-183. PMID:11805837
  11. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  12. [ + ] Dujon B, et al. (1994) "Complete DNA sequence of yeast chromosome XI." Nature. 369(6479):371-378. PMID:8196765