ADE3 | GeneID:853118 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 853118 Official Symbol ADE3
Locus YGR204W Gene Type protein-coding
Full Name N/A
Description Ade3p
Chromosome N/A
Also Known As Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 55940

ID Symbol Protein Species
GeneID:4522 MTHFD1 NP_005947.2 Homo sapiens
GeneID:41279 pug NP_731489.2 Drosophila melanogaster
GeneID:64300 Mthfd1 NP_071953.1 Rattus norvegicus
GeneID:108156 Mthfd1 NP_620084.1 Mus musculus
GeneID:181064 K07E3.4 NP_509360.1 Caenorhabditis elegans
GeneID:260441 mthfd1 NP_955823.1 Danio rerio
GeneID:423508 MTHFD1 NP_001034392.1 Gallus gallus
GeneID:452965 MTHFD1 XP_001170520.1 Pan troglodytes
GeneID:480352 MTHFD1 XP_537476.2 Canis lupus familiaris
GeneID:534382 MTHFD1 XP_614133.2 Bos taurus
GeneID:841470 THFS NP_564571.1 Arabidopsis thaliana
GeneID:853118 ADE3 NP_011720.1 Saccharomyces cerevisiae
GeneID:1273131 AgaP_AGAP002830 XP_312083.2 Anopheles gambiae
GeneID:2541217 SPBC839.16 NP_595256.1 Schizosaccharomyces pombe
GeneID:2674667 MGG_01014 XP_368230.2 Magnaporthe grisea
GeneID:2705121 NCU03877.1 XP_323196.1 Neurospora crassa
GeneID:2894215 KLLA0E16588g XP_454695.1 Kluyveromyces lactis
GeneID:4347204 Os09g0446800 NP_001063310.1 Oryza sativa
GeneID:4619403 AGOS_ACL121C NP_983283.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0005634 Component nucleus
GO:0005524 Function ATP binding
GO:0005488 Function binding
GO:0003824 Function catalytic activity
GO:0004329 Function formate-tetrahydrofolate ligase activity
GO:0016787 Function hydrolase activity
GO:0016874 Function ligase activity
GO:0004477 Function methenyltetrahydrofolate cyclohydrolase activity
GO:0004488 Function methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0000166 Function nucleotide binding
GO:0016491 Function oxidoreductase activity
GO:0008652 Process cellular amino acid biosynthetic process
GO:0009396 Process folic acid and derivative biosynthetic process
GO:0006760 Process folic acid and derivative metabolic process
GO:0000105 Process histidine biosynthetic process
GO:0008152 Process metabolic process
GO:0009086 Process methionine biosynthetic process
GO:0006730 Process one-carbon compound metabolic process
GO:0055114 Process oxidation reduction
GO:0009113 Process purine base biosynthetic process
GO:0006164 Process purine nucleotide biosynthetic process

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ARB1 ARB1 / ADE3 Affinity Capture-MS Dong J (2005)
FAU1 ADE3 / FAU1 Phenotypic Enhancement Rebora K (2005)
FAU1 ADE3 / FAU1 Synthetic Growth Defect Rebora K (2005)
FPR1 FPR1 / ADE3 Affinity Capture-MS Ho Y (2002)
GCN5 GCN5 / ADE3 Affinity Capture-MS Graumann J (2004)
HIP1 ADE3 / HIP1 Synthetic Lethality Koren A (2003)
HIP1 HIP1 / ADE3 Synthetic Lethality Koren A (2003)
MET6 ADE3 / MET6 Phenotypic Enhancement Rebora K (2005)
MIS1 ADE3 / MIS1 Affinity Capture-MS Krogan NJ (2006)
PHO4 PHO4 / ADE3 Affinity Capture-MS Graumann J (2004)
PMU1 ADE3 / PMU1 Dosage Rescue Rebora K (2005)
PRP6 PRP6 / ADE3 Affinity Capture-MS Ho Y (2002)
PSA1 ADE3 / PSA1 Affinity Capture-MS Gavin AC (2006)
RPL2A RPL2A / ADE3 Affinity Capture-MS Gavin AC (2002)
RPL2A RPL2A / ADE3 Affinity Capture-MS Gavin AC (2006)
RPS1A ADE3 / RPS1A Affinity Capture-MS Gavin AC (2006)
SHE2 SHE2 / ADE3 Affinity Capture-RNA Oeffinger M (2007)
SHM1 ADE3 / SHM1 Synthetic Lethality Koren A (2003)
SHM1 SHM1 / ADE3 Synthetic Lethality Koren A (2003)
SHM2 SHM2 / ADE3 Synthetic Lethality Nigavekar SS (2002)
SHM2 ADE3 / SHM2 Synthetic Lethality Rebora K (2005)
SRP40 SRP40 / ADE3 Synthetic Lethality Yang Y (2003)
TMA108 TMA108 / ADE3 Affinity Capture-MS Krogan NJ (2006)
UBA1 UBA1 / ADE3 Affinity Capture-MS Krogan NJ (2006)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Oeffinger M, et al. (2007) "Comprehensive analysis of diverse ribonucleoprotein complexes." Nat Methods. 4(11):951-956. PMID:17922018
  2. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  3. [ + ] Gavin AC, et al. (2006) "Proteome survey reveals modularity of the yeast cell machinery." Nature. 440(7084):631-636. PMID:16429126
  4. [ + ] Dong J, et al. (2005) "The novel ATP-binding cassette protein ARB1 is a shuttling factor that stimulates 40S and 60S ribosome biogenesis." Mol Cell Biol. 25(22):9859-9873. PMID:16260602
  5. [ + ] Rebora K, et al. (2005) "Revisiting purine-histidine cross-pathway regulation in Saccharomyces cerevisiae: a central role for a small molecule." Genetics. 170(1):61-70. PMID:15744050
  6. [ + ] Graumann J, et al. (2004) "Applicability of tandem affinity purification MudPIT to pathway proteomics in yeast." Mol Cell Proteomics. 3(3):226-237. PMID:14660704
  7. [ + ] Koren A, et al. (2003) "Pitfalls of the synthetic lethality screen in Saccharomyces cerevisiae: an improved design." Curr Genet. 43(1):62-69. PMID:12684846
  8. [ + ] Yang Y, et al. (2003) "Genetic interaction between a chaperone of small nucleolar ribonucleoprotein particles and cytosolic serine hydroxymethyltransferase." J Biol Chem. 278(26):23553-23560. PMID:12700234
  9. [ + ] Huh WK, et al. (2003) "Global analysis of protein localization in budding yeast." Nature. 425(6959):686-691. PMID:14562095
  10. [ + ] Kumar A, et al. (2002) "Subcellular localization of the yeast proteome." Genes Dev. 16(6):707-719. PMID:11914276
  11. [ + ] Ho Y, et al. (2002) "Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry." Nature. 415(6868):180-183. PMID:11805837
  12. [ + ] Gavin AC, et al. (2002) "Functional organization of the yeast proteome by systematic analysis of protein complexes." Nature. 415(6868):141-147. PMID:11805826
  13. [ + ] Nigavekar SS, et al. (2002) "Characterization of genes that are synthetically lethal with ade3 or leu2 in Saccharomyces cerevisiae." Yeast. 19(2):115-122. PMID:11788966
  14. [ + ] Tettelin H, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Nature. 387(6632 Suppl):81-84. PMID:9169869
  15. [ + ] McNeil JB, et al. (1996) "In vivo analysis of folate coenzymes and their compartmentation in Saccharomyces cerevisiae." Genetics. 142(2):371-381. PMID:8852837
  16. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  17. [ + ] Song JM, et al. (1993) "Function of yeast cytoplasmic C1-tetrahydrofolate synthase." Proc Natl Acad Sci U S A. 90(7):2636-2640. PMID:8464869