ADE6 | GeneID:852952 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 852952 Official Symbol ADE6
Locus YGR061C Gene Type protein-coding
Synonyms
Full Name N/A
Description Ade6p
Chromosome N/A
Also Known As Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 101592

ID Symbol Protein Species
GeneID:852952 ADE6 NP_011575.1 Saccharomyces cerevisiae
GeneID:2542871 ade3 NP_593296.1 Schizosaccharomyces pombe
GeneID:2711710 NCU08685.1 XP_329809.1 Neurospora crassa
GeneID:2897462 KLLA0B08063g XP_451889.1 Kluyveromyces lactis
GeneID:4622402 AGOS_AFR573C NP_986120.1 Eremothecium gossypii
GeneID:5050698 MGG_11541 XP_001410996.1 Magnaporthe grisea

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0005524 Function ATP binding
GO:0003824 Function catalytic activity
GO:0016874 Function ligase activity
GO:0000166 Function nucleotide binding
GO:0004642 Function phosphoribosylformylglycinamidine synthase activity
GO:0006189 Process 'de novo' IMP biosynthetic process
GO:0006541 Process glutamine metabolic process
GO:0006164 Process purine nucleotide biosynthetic process
GO:0042254 Process ribosome biogenesis

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

CAA97063   NP_011575   P38972   S64356  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ADE2 ADE2 / ADE6 Phenotypic Suppression Zekhnov AM (1998)
PRP45 PRP45 / ADE6 Two-hybrid Albers M (2003)
PRP6 PRP6 / ADE6 Affinity Capture-MS Ho Y (2002)
RAS2 RAS2 / ADE6 Synthetic Rescue Cannon JF (1986)
SMT3 SMT3 / ADE6 Affinity Capture-MS Hannich JT (2005)
UBP2 UBP2 / ADE6 Affinity Capture-MS Krogan NJ (2006)
VAC14 ADE6 / VAC14 Two-hybrid Uetz P (2000)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  2. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  3. [ + ] Hannich JT, et al. (2005) "Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae." J Biol Chem. 280(6):4102-4110. PMID:15590687
  4. [ + ] Albers M, et al. (2003) "Identification and characterization of Prp45p and Prp46p, essential pre-mRNA splicing factors." RNA. 9(1):138-150. PMID:12554883
  5. [ + ] Huh WK, et al. (2003) "Global analysis of protein localization in budding yeast." Nature. 425(6959):686-691. PMID:14562095
  6. [ + ] Ho Y, et al. (2002) "Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry." Nature. 415(6868):180-183. PMID:11805837
  7. [ + ] Uetz P, et al. (2000) "A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae." Nature. 403(6770):623-627. PMID:10688190
  8. [ + ] Zekhnov AM, et al. (1998) "[New phenotypic manifestation of the ad2 mutation in Saccharomyces cerevisiae yeast--the inability to grow on a synthetic medium with glycerol and hypoxanthine]" Genetika. 34(2):190-197. PMID:9589850
  9. [ + ] Tettelin H, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Nature. 387(6632 Suppl):81-84. PMID:9169869
  10. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  11. [ + ] Giani S, et al. (1991) "Cloning and transcriptional analysis of the ADE6 gene of Saccharomyces cerevisiae." Gene. 107(1):149-154. PMID:1743513
  12. [ + ] Cannon JF, et al. (1986) "Suppressors of the ras2 mutation of Saccharomyces cerevisiae." Genetics. 113(2):247-264. PMID:3013722