ACB1 | GeneID:852925 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 852925 Official Symbol ACB1
Locus YGR037C Gene Type protein-coding
Full Name N/A
Description Acb1p
Chromosome N/A
Also Known As Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 39086

ID Symbol Protein Species
GeneID:1622 DBI NP_065438.1 Homo sapiens
GeneID:13167 Dbi NP_001033088.1 Mus musculus
GeneID:25045 Dbi NP_114054.1 Rattus norvegicus
GeneID:38784 Dbi NP_523952.2 Drosophila melanogaster
GeneID:172071 acbp-1 NP_491412.1 Caenorhabditis elegans
GeneID:393831 zgc:77734 NP_955902.1 Danio rerio
GeneID:395263 DBI NP_989907.1 Gallus gallus
GeneID:459574 DBI XP_001156427.1 Pan troglodytes
GeneID:476115 DBI XP_849337.1 Canis lupus familiaris
GeneID:768330 DBI XP_869302.1 Bos taurus
GeneID:852925 ACB1 NP_011551.1 Saccharomyces cerevisiae
GeneID:1269756 AgaP_AGAP007460 XP_308405.2 Anopheles gambiae
GeneID:2539982 SPBC1539.06 NP_596820.1 Schizosaccharomyces pombe
GeneID:4619336 AGOS_ACL188W NP_983216.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0005634 Component nucleus
GO:0000062 Function acyl-CoA binding
GO:0005488 Function binding
GO:0008289 Function lipid binding
GO:0005324 Function long-chain fatty acid transporter activity
GO:0045454 Process cell redox homeostasis
GO:0006631 Process fatty acid metabolic process
GO:0015909 Process long-chain fatty acid transport
GO:0006508 Process proteolysis
GO:0006810 Process transport

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ADE13 ACB1 / ADE13 Affinity Capture-MS Krogan NJ (2006)
ADE17 ACB1 / ADE17 PCA Tarassov K (2008)
ALO1 ACB1 / ALO1 PCA Tarassov K (2008)
ARC40 ARC40 / ACB1 PCA Tarassov K (2008)
BI2 ACB1 / BI2 Affinity Capture-MS Krogan NJ (2006)
FRE7 ACB1 / FRE7 Affinity Capture-MS Krogan NJ (2006)
HUG1 ACB1 / HUG1 PCA Tarassov K (2008)
JNM1 JNM1 / ACB1 Synthetic Lethality Schoner D (2008)
KNS1 ACB1 / KNS1 Affinity Capture-MS Krogan NJ (2006)
NUP170 ACB1 / NUP170 Affinity Capture-MS Krogan NJ (2006)
SEC26 SEC26 / ACB1 PCA Tarassov K (2008)
SEC27 SEC27 / ACB1 PCA Tarassov K (2008)
SEC5 ACB1 / SEC5 Affinity Capture-MS Krogan NJ (2006)
SHE2 SHE2 / ACB1 Affinity Capture-RNA Oeffinger M (2007)
STE2 ACB1 / STE2 Affinity Capture-MS Krogan NJ (2006)
VMA7 VMA7 / ACB1 PCA Tarassov K (2008)
VMA8 VMA8 / ACB1 PCA Tarassov K (2008)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  2. [ + ] Tarassov K, et al. (2008) "An in vivo map of the yeast protein interactome." Science. 320(5882):1465-1470. PMID:18467557
  3. [ + ] Schoner D, et al. (2008) "Annotating novel genes by integrating synthetic lethals and genomic information." BMC Syst Biol. 2():3. PMID:18194531
  4. [ + ] Feddersen S, et al. (2007) "Transcriptional regulation of phospholipid biosynthesis is linked to fatty acid metabolism by an acyl-CoA-binding-protein-dependent mechanism in Saccharomyces cerevisiae." Biochem J. 407(2):219-230. PMID:17593018
  5. [ + ] Oeffinger M, et al. (2007) "Comprehensive analysis of diverse ribonucleoprotein complexes." Nat Methods. 4(11):951-956. PMID:17922018
  6. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  7. [ + ] Huh WK, et al. (2003) "Global analysis of protein localization in budding yeast." Nature. 425(6959):686-691. PMID:14562095
  8. [ + ] Gaigg B, et al. (2001) "Depletion of acyl-coenzyme A-binding protein affects sphingolipid synthesis and causes vesicle accumulation and membrane defects in Saccharomyces cerevisiae." Mol Biol Cell. 12(4):1147-1160. PMID:11294913
  9. [ + ] Tettelin H, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Nature. 387(6632 Suppl):81-84. PMID:9169869
  10. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  11. [ + ] Schjerling CK, et al. (1996) "Disruption of the gene encoding the acyl-CoA-binding protein (ACB1) perturbs acyl-CoA metabolism in Saccharomyces cerevisiae." J Biol Chem. 271(37):22514-22521. PMID:8798418
  12. [ + ] Rose TM, et al. (1992) "Molecular cloning of the gene for the yeast homolog (ACB) of diazepam binding inhibitor/endozepine/acyl-CoA-binding protein." Proc Natl Acad Sci U S A. 89(23):11287-11291. PMID:1454809