AFT1 | GeneID:852809 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 852809 Official Symbol AFT1
Locus YGL071W Gene Type protein-coding
Synonyms RCS1
Full Name N/A
Description Aft1p
Chromosome N/A
Also Known As Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability
Summary N/A

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0005634 Component nucleus
GO:0005506 Function iron ion binding
GO:0046872 Function metal ion binding
GO:0043565 Function sequence-specific DNA binding
GO:0003700 Function transcription factor activity
GO:0006827 Process high-affinity iron ion transport
GO:0006811 Process ion transport
GO:0045944 Process positive regulation of transcription from RNA polymerase II promoter
GO:0006355 Process regulation of transcription, DNA-dependent
GO:0006417 Process regulation of translation
GO:0006350 Process transcription

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]


Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

AAU09722   CAA88044   CAA96775   NP_011444   P22149   S54775  

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Kumanovics A, et al. (2008) "Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis." J Biol Chem. 283(16):10276-10286. PMID:18281282
  2. [ + ] Irazusta V, et al. (2008) "Major targets of iron-induced protein oxidative damage in frataxin-deficient yeasts are magnesium-binding proteins." Free Radic Biol Med. 44(9):1712-1723. PMID:18280258
  3. [ + ] Mitchell L, et al. (2008) "Functional dissection of the NuA4 histone acetyltransferase reveals its role as a genetic hub and that Eaf1 is essential for complex integrity." Mol Cell Biol. 28(7):2244-2256. PMID:18212056
  4. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  5. [ + ] Kimura A, et al. (2007) "Cisplatin upregulates Saccharomyces cerevisiae genes involved in iron homeostasis through activation of the iron insufficiency-responsive transcription factor Aft1." J Cell Physiol. 210(2):378-384. PMID:17096368
  6. [ + ] Wong J, et al. (2007) "A protein interaction map of the mitotic spindle." Mol Biol Cell. 18(10):3800-3809. PMID:17634282
  7. [ + ] Ueta R, et al. (2007) "Mechanism underlying the iron-dependent nuclear export of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae." Mol Biol Cell. 18(8):2980-2990. PMID:17538022
  8. [ + ] Crisp RJ, et al. (2006) "Recruitment of Tup1p and Cti6p regulates heme-deficient expression of Aft1p target genes." EMBO J. 25(3):512-521. PMID:16437160
  9. [ + ] Dubacq C, et al. (2006) "Role of the iron mobilization and oxidative stress regulons in the genomic response of yeast to hydroxyurea." Mol Genet Genomics. 275(2):114-124. PMID:16328372
  10. [ + ] Pan X, et al. (2006) "A DNA integrity network in the yeast Saccharomyces cerevisiae." Cell. 124(5):1069-1081. PMID:16487579
  11. [ + ] Ojeda L, et al. (2006) "Role of glutaredoxin-3 and glutaredoxin-4 in the iron regulation of the Aft1 transcriptional activator in Saccharomyces cerevisiae." J Biol Chem. 281(26):17661-17669. PMID:16648636
  12. [ + ] Pujol-Carrion N, et al. (2006) "Glutaredoxins Grx3 and Grx4 regulate nuclear localisation of Aft1 and the oxidative stress response in Saccharomyces cerevisiae." J Cell Sci. 119(Pt 21):4554-4564. PMID:17074835
  13. [ + ] Kawahata M, et al. (2006) "Yeast genes involved in response to lactic acid and acetic acid: acidic conditions caused by the organic acids in Saccharomyces cerevisiae cultures induce expression of intracellular metal metabolism genes regulated by Aft1p." FEMS Yeast Res. 6(6):924-936. PMID:16911514
  14. [ + ] Measday V, et al. (2005) "Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation." Proc Natl Acad Sci U S A. 102(39):13956-13961. PMID:16172405
  15. [ + ] Rutherford JC, et al. (2005) "Activation of the iron regulon by the yeast Aft1/Aft2 transcription factors depends on mitochondrial but not cytosolic iron-sulfur protein biogenesis." J Biol Chem. 280(11):10135-10140. PMID:15649888
  16. [ + ] Courel M, et al. (2005) "Direct activation of genes involved in intracellular iron use by the yeast iron-responsive transcription factor Aft2 without its paralog Aft1." Mol Cell Biol. 25(15):6760-6771. PMID:16024809
  17. [ + ] Fragiadakis GS, et al. (2004) "Nhp6 facilitates Aft1 binding and Ssn6 recruitment, both essential for FRE2 transcriptional activation." EMBO J. 23(2):333-342. PMID:14739928
  18. [ + ] Ueta R, et al. (2003) "Pse1p mediates the nuclear import of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae." J Biol Chem. 278(50):50120-50127. PMID:14523005
  19. [ + ] Yamaguchi-Iwai Y, et al. (2002) "Subcellular localization of Aft1 transcription factor responds to iron status in Saccharomyces cerevisiae." J Biol Chem. 277(21):18914-18918. PMID:11877447
  20. [ + ] Portnoy ME, et al. (2002) "The distinct methods by which manganese and iron regulate the Nramp transporters in yeast." Biochem J. 362(Pt 1):119-124. PMID:11829747
  21. [ + ] Blaiseau PL, et al. (2001) "Aft2p, a novel iron-regulated transcription activator that modulates, with Aft1p, intracellular iron use and resistance to oxidative stress in yeast." J Biol Chem. 276(36):34221-34226. PMID:11448968
  22. [ + ] Rutherford JC, et al. (2001) "A second iron-regulatory system in yeast independent of Aft1p." Proc Natl Acad Sci U S A. 98(25):14322-14327. PMID:11734641
  23. [ + ] Uetz P, et al. (2000) "A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae." Nature. 403(6770):623-627. PMID:10688190
  24. [ + ] Philpott CC, et al. (1998) "Cell-cycle arrest and inhibition of G1 cyclin translation by iron in AFT1-1(up) yeast." EMBO J. 17(17):5026-5036. PMID:9724638
  25. [ + ] Tettelin H, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Nature. 387(6632 Suppl):81-84. PMID:9169869
  26. [ + ] Yamaguchi-Iwai Y, et al. (1996) "Iron-regulated DNA binding by the AFT1 protein controls the iron regulon in yeast." EMBO J. 15(13):3377-3384. PMID:8670839
  27. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  28. [ + ] Milne GT, et al. (1995) "Modulation of Saccharomyces cerevisiae DNA double-strand break repair by SRS2 and RAD51." Genetics. 139(3):1189-1199. PMID:7768432