ABC1 | GeneID:852758 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 852758 Official Symbol ABC1
Locus YGL119W Gene Type protein-coding
Synonyms COQ8
Full Name N/A
Description Abc1p
Chromosome N/A
Also Known As Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 86731

ID Symbol Protein Species
GeneID:32239 CG32649 NP_572836.1 Drosophila melanogaster
GeneID:76889 Adck4 NP_598531.2 Mus musculus
GeneID:79934 ADCK4 NP_079152.3 Homo sapiens
GeneID:308453 Adck4 NP_001012065.1 Rattus norvegicus
GeneID:456045 ADCK4 XP_512672.2 Pan troglodytes
GeneID:484498 ADCK4 XP_541612.2 Canis lupus familiaris
GeneID:799071 LOC799071 XP_001336310.1 Danio rerio
GeneID:852758 ABC1 NP_011396.1 Saccharomyces cerevisiae
GeneID:1273054 AgaP_AGAP002906 XP_311995.2 Anopheles gambiae
GeneID:2540411 abc1 NP_596237.1 Schizosaccharomyces pombe
GeneID:2685112 MGG_06939 XP_370442.1 Magnaporthe grisea
GeneID:2704936 NCU03823.1 XP_323124.1 Neurospora crassa
GeneID:2897197 KLLA0B00539g XP_451554.1 Kluyveromyces lactis
GeneID:4618760 AGOS_AAR181W NP_982724.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005759 Component mitochondrial matrix
GO:0005739 Component mitochondrion
GO:0003674 Function molecular_function
GO:0009060 Process aerobic respiration
GO:0006744 Process ubiquinone biosynthetic process

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

CAA41759   CAA96827   NP_011396   P27697   S16711  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
CBS2 CBS2 / ABC1 Dosage Rescue Bousquet I (1991)
COQ9 COQ9 / ABC1 Dosage Rescue Hsieh EJ (2007)
COQ9 COQ9 / ABC1 Phenotypic Suppression Johnson A (2005)
N/A N/A / ABC1 Dosage Rescue Barros MH (2005)
PCL1 PCL1 / ABC1 Biochemical Activity Ptacek J (2005)
SKS1 SKS1 / ABC1 Biochemical Activity Ptacek J (2005)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Tauche A, et al. (2008) "Ubiquinone biosynthesis in Saccharomyces cerevisiae: the molecular organization of O-methylase Coq3p depends on Abc1p/Coq8p." FEMS Yeast Res. 8(8):1263-1275. PMID:18801050
  2. [ + ] Hsieh EJ, et al. (2007) "Saccharomyces cerevisiae Coq9 polypeptide is a subunit of the mitochondrial coenzyme Q biosynthetic complex." Arch Biochem Biophys. 463(1):19-26. PMID:17391640
  3. [ + ] Reinders J, et al. (2006) "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." J Proteome Res. 5(7):1543-1554. PMID:16823961
  4. [ + ] Johnson A, et al. (2005) "COQ9, a new gene required for the biosynthesis of coenzyme Q in Saccharomyces cerevisiae." J Biol Chem. 280(36):31397-31404. PMID:16027161
  5. [ + ] Barros MH, et al. (2005) "The Saccharomyces cerevisiae COQ10 gene encodes a START domain protein required for function of coenzyme Q in respiration." J Biol Chem. 280(52):42627-42635. PMID:16230336
  6. [ + ] Ptacek J, et al. (2005) "Global analysis of protein phosphorylation in yeast." Nature. 438(7068):679-684. PMID:16319894
  7. [ + ] Sickmann A, et al. (2003) "The proteome of Saccharomyces cerevisiae mitochondria." Proc Natl Acad Sci U S A. 100(23):13207-13212. PMID:14576278
  8. [ + ] Do TQ, et al. (2001) "A defect in coenzyme Q biosynthesis is responsible for the respiratory deficiency in Saccharomyces cerevisiae abc1 mutants." J Biol Chem. 276(21):18161-18168. PMID:11279158
  9. [ + ] Tettelin H, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Nature. 387(6632 Suppl):81-84. PMID:9169869
  10. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  11. [ + ] Bousquet I, et al. (1991) "ABC1, a novel yeast nuclear gene has a dual function in mitochondria: it suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex." EMBO J. 10(8):2023-2031. PMID:1648478