ADH4 | GeneID:852636 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 852636 Official Symbol ADH4
Locus YGL256W Gene Type protein-coding
Synonyms NRC465; ZRG5
Full Name N/A
Description Adh4p
Chromosome N/A
Also Known As Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 74667

ID Symbol Protein Species
GeneID:852636 ADH4 NP_011258.1 Saccharomyces cerevisiae
GeneID:1268019 ENSANGG00000000909 XP_306578.1 Anopheles gambiae
GeneID:2542714 adh4 NP_592819.1 Schizosaccharomyces pombe
GeneID:2892301 KLLA0C19382g XP_453065.1 Kluyveromyces lactis

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005739 Component mitochondrion
GO:0004022 Function alcohol dehydrogenase (NAD) activity
GO:0046872 Function metal ion binding
GO:0016491 Function oxidoreductase activity
GO:0008270 Function zinc ion binding
GO:0000947 Process amino acid catabolic process to alcohol via Ehrlich pathway
GO:0006113 Process fermentation
GO:0055114 Process oxidation reduction
GO:0006417 Process regulation of translation

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

CAA64131   CAA96976   DEBY4   NP_011258   P10127  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ARF3 ADH4 / ARF3 PCA Tarassov K (2008)
BCK1 BCK1 / ADH4 Biochemical Activity Ptacek J (2005)
CDC13 CDC13 / ADH4 Affinity Capture-MS Ho Y (2002)
DUN1 DUN1 / ADH4 Affinity Capture-MS Ho Y (2002)
ERJ5 ERJ5 / ADH4 PCA Tarassov K (2008)
GLC7 GLC7 / ADH4 Affinity Capture-MS Ho Y (2002)
KAP104 KAP104 / ADH4 Affinity Capture-MS Ho Y (2002)
KSP1 KSP1 / ADH4 Biochemical Activity Ptacek J (2005)
MCK1 MCK1 / ADH4 Biochemical Activity Ptacek J (2005)
RAD26 RAD26 / ADH4 Affinity Capture-MS Ho Y (2002)
SLD2 SLD2 / ADH4 Affinity Capture-MS Ho Y (2002)
SUI1 SUI1 / ADH4 Affinity Capture-MS Ho Y (2002)
SWI6 ADH4 / SWI6 PCA Tarassov K (2008)
YCK1 YCK1 / ADH4 Biochemical Activity Ptacek J (2005)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  2. [ + ] Tarassov K, et al. (2008) "An in vivo map of the yeast protein interactome." Science. 320(5882):1465-1470. PMID:18467557
  3. [ + ] Ptacek J, et al. (2005) "Global analysis of protein phosphorylation in yeast." Nature. 438(7068):679-684. PMID:16319894
  4. [ + ] Dickinson JR, et al. (2003) "The catabolism of amino acids to long chain and complex alcohols in Saccharomyces cerevisiae." J Biol Chem. 278(10):8028-8034. PMID:12499363
  5. [ + ] Huh WK, et al. (2003) "Global analysis of protein localization in budding yeast." Nature. 425(6959):686-691. PMID:14562095
  6. [ + ] Ho Y, et al. (2002) "Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry." Nature. 415(6868):180-183. PMID:11805837
  7. [ + ] Tettelin H, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Nature. 387(6632 Suppl):81-84. PMID:9169869
  8. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  9. [ + ] Drewke C, et al. (1988) "Overexpression, purification and properties of alcohol dehydrogenase IV from Saccharomyces cerevisiae." Biochim Biophys Acta. 950(1):54-60. PMID:3282541
  10. [ + ] Paquin CE, et al. (1986) "Ty insertions at two loci account for most of the spontaneous antimycin A resistance mutations during growth at 15 degrees C of Saccharomyces cerevisiae strains lacking ADH1." Mol Cell Biol. 6(1):70-79. PMID:3023838