ADE5,7 | GeneID:852617 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 852617 Official Symbol ADE5,7
Locus YGL234W Gene Type protein-coding
Synonyms
Full Name N/A
Description Ade5,7p
Chromosome N/A
Also Known As Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 637

ID Symbol Protein Species
GeneID:2618 GART NP_000810.1 Homo sapiens
GeneID:14450 Gart NP_034386.2 Mus musculus
GeneID:33986 ade3 NP_523497.2 Drosophila melanogaster
GeneID:58141 gart NP_571692.1 Danio rerio
GeneID:180935 GARS/AIRS/GART NP_509122.1 Caenorhabditis elegans
GeneID:281183 GART NP_001035563.1 Bos taurus
GeneID:288259 Gart XP_573258.1 Rattus norvegicus
GeneID:395315 GART NP_001001469.1 Gallus gallus
GeneID:458518 GART XP_514869.2 Pan troglodytes
GeneID:837515 AT1G09830 NP_172454.1 Arabidopsis thaliana
GeneID:852617 ADE5,7 NP_011280.1 Saccharomyces cerevisiae
GeneID:1279199 AgaP_AGAP009786 XP_318881.2 Anopheles gambiae
GeneID:2541034 ade1 NP_596304.1 Schizosaccharomyces pombe
GeneID:2704394 NCU00177.1 XP_322263.1 Neurospora crassa
GeneID:2896609 KLLA0A00957g XP_451041.1 Kluyveromyces lactis
GeneID:4344854 Os08g0191200 NP_001061170.1 Oryza sativa
GeneID:4351721 Os12g0197100 NP_001066357.1 Oryza sativa
GeneID:4622064 AGOS_AFR254C NP_985801.1 Eremothecium gossypii
GeneID:5051303 MGG_11343 XP_001413666.1 Magnaporthe grisea

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0005524 Function ATP binding
GO:0003824 Function catalytic activity
GO:0016874 Function ligase activity
GO:0030145 Function manganese ion binding
GO:0046872 Function metal ion binding
GO:0000166 Function nucleotide binding
GO:0004637 Function phosphoribosylamine-glycine ligase activity
GO:0004641 Function phosphoribosylformylglycinamidine cyclo-ligase activity
GO:0006189 Process 'de novo' IMP biosynthetic process
GO:0009113 Process purine base biosynthetic process
GO:0006144 Process purine base metabolic process
GO:0006164 Process purine nucleotide biosynthetic process

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

A26343   CAA27867   CAA96952   NP_011280   P07244  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ADE2 ADE2 / ADE5,7 Phenotypic Suppression Zekhnov AM (1998)
AKL1 AKL1 / ADE5,7 Biochemical Activity Ptacek J (2005)
ATG12 ATG12 / ADE5,7 Affinity Capture-MS Ho Y (2002)
GSY2 ADE5,7 / GSY2 Affinity Capture-MS Krogan NJ (2006)
HSC82 HSC82 / ADE5,7 Synthetic Growth Defect McClellan AJ (2007)
HSP82 HSP82 / ADE5,7 Synthetic Growth Defect McClellan AJ (2007)
LSM2 LSM2 / ADE5,7 Affinity Capture-MS Ho Y (2002)
PHO80 PHO80 / ADE5,7 Biochemical Activity Ptacek J (2005)
PIN3 PIN3 / ADE5,7 Two-hybrid Tong AH (2002)
REB1 REB1 / ADE5,7 Affinity Capture-MS Gavin AC (2002)
REB1 REB1 / ADE5,7 Affinity Capture-MS Gavin AC (2006)
RFC2 RFC2 / ADE5,7 Affinity Capture-MS Ho Y (2002)
RFC4 RFC4 / ADE5,7 Affinity Capture-MS Ho Y (2002)
RPS3 ADE5,7 / RPS3 Affinity Capture-MS Gavin AC (2006)
RPS5 ADE5,7 / RPS5 Affinity Capture-MS Gavin AC (2006)
TPK3 TPK3 / ADE5,7 Affinity Capture-MS Ho Y (2002)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] McClellan AJ, et al. (2007) "Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches." Cell. 131(1):121-135. PMID:17923092
  2. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  3. [ + ] Gavin AC, et al. (2006) "Proteome survey reveals modularity of the yeast cell machinery." Nature. 440(7084):631-636. PMID:16429126
  4. [ + ] Ptacek J, et al. (2005) "Global analysis of protein phosphorylation in yeast." Nature. 438(7068):679-684. PMID:16319894
  5. [ + ] Huh WK, et al. (2003) "Global analysis of protein localization in budding yeast." Nature. 425(6959):686-691. PMID:14562095
  6. [ + ] Ho Y, et al. (2002) "Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry." Nature. 415(6868):180-183. PMID:11805837
  7. [ + ] Tong AH, et al. (2002) "A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules." Science. 295(5553):321-324. PMID:11743162
  8. [ + ] Gavin AC, et al. (2002) "Functional organization of the yeast proteome by systematic analysis of protein complexes." Nature. 415(6868):141-147. PMID:11805826
  9. [ + ] Kumar A, et al. (2002) "Subcellular localization of the yeast proteome." Genes Dev. 16(6):707-719. PMID:11914276
  10. [ + ] Zekhnov AM, et al. (1998) "[New phenotypic manifestation of the ad2 mutation in Saccharomyces cerevisiae yeast--the inability to grow on a synthetic medium with glycerol and hypoxanthine]" Genetika. 34(2):190-197. PMID:9589850
  11. [ + ] Tettelin H, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Nature. 387(6632 Suppl):81-84. PMID:9169869
  12. [ + ] Rolfes RJ, et al. (1997) "The transcriptional activators BAS1, BAS2, and ABF1 bind positive regulatory sites as the critical elements for adenine regulation of ADE5,7." J Biol Chem. 272(20):13343-13354. PMID:9148957
  13. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441