ABD1 | GeneID:852538 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 852538 Official Symbol ABD1
Locus YBR236C Gene Type protein-coding
Synonyms
Full Name N/A
Description Abd1p
Chromosome N/A
Also Known As Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 2816

ID Symbol Protein Species
GeneID:8731 RNMT NP_003790.1 Homo sapiens
GeneID:34877 l(2)35Bd NP_523568.2 Drosophila melanogaster
GeneID:67897 Rnmt NP_080716.1 Mus musculus
GeneID:182875 tag-72 NP_492674.2 Caenorhabditis elegans
GeneID:291534 Rnmt NP_001008300.1 Rattus norvegicus
GeneID:421046 RNMT XP_419132.1 Gallus gallus
GeneID:455501 RNMT XP_001171239.1 Pan troglodytes
GeneID:476200 RNMT XP_533404.2 Canis lupus familiaris
GeneID:511555 RNMT XP_870910.1 Bos taurus
GeneID:562801 si:ch211-105d11.3 NP_001038465.1 Danio rerio
GeneID:821612 AT3G20650 NP_188701.2 Arabidopsis thaliana
GeneID:852538 ABD1 NP_009795.1 Saccharomyces cerevisiae
GeneID:1272829 AgaP_AGAP003460 XP_311746.2 Anopheles gambiae
GeneID:2539280 pcm1 NP_587710.1 Schizosaccharomyces pombe
GeneID:2684660 MGG_06505 XP_369990.1 Magnaporthe grisea
GeneID:2705107 NCU03971.1 XP_323290.1 Neurospora crassa
GeneID:2895726 KLLA0F10527g XP_455559.1 Kluyveromyces lactis
GeneID:4344818 Os08g0180000 NP_001061136.1 Oryza sativa
GeneID:4621755 AGOS_AFL026W NP_985522.1 Eremothecium gossypii
GeneID:100000432 LOC100000432 XP_001923422.1 Danio rerio

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0016591 Component DNA-directed RNA polymerase II, holoenzyme
GO:0005634 Component nucleus
GO:0008168 Function methyltransferase activity
GO:0004482 Function mRNA (guanine-N7-)-methyltransferase activity
GO:0003723 Function RNA binding
GO:0016740 Function transferase activity
GO:0006370 Process mRNA capping
GO:0006397 Process mRNA processing

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

AAA34383   CAA85199   NP_009795   P32783   S41782  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ARP2 ARP2 / ABD1 Synthetic Lethality Davierwala AP (2005)
CDC34 ABD1 / CDC34 Dosage Rescue Schwer B (2000)
CDC34 CDC34 / ABD1 Phenotypic Enhancement Schwer B (2000)
DOA1 ABD1 / DOA1 Phenotypic Enhancement Wilmes GM (2008)
NIP7 NIP7 / ABD1 Synthetic Lethality Davierwala AP (2005)
RPB2 ABD1 / RPB2 Affinity Capture-MS Gavin AC (2002)
RPO21 RPO21 / ABD1 Affinity Capture-Western McCracken S (1997)
RPO21 ABD1 / RPO21 Reconstituted Complex Schroeder SC (2000)
SAM1 ABD1 / SAM1 Dosage Rescue Schwer B (2000)
SAM1 ABD1 / SAM1 Phenotypic Enhancement Zheng S (2007)
SAM2 ABD1 / SAM2 Dosage Rescue Schwer B (2000)
SAM2 ABD1 / SAM2 Phenotypic Enhancement Zheng S (2007)
SPT4 SPT4 / ABD1 Affinity Capture-MS Lindstrom DL (2003)
SPT5 ABD1 / SPT5 Affinity Capture-MS Gavin AC (2002)
SPT5 ABD1 / SPT5 Affinity Capture-MS Lindstrom DL (2003)
SPT5 SPT5 / ABD1 Affinity Capture-MS Lindstrom DL (2003)
SPT6 SPT6 / ABD1 Affinity Capture-MS Lindstrom DL (2003)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Zheng S, et al. (2007) "Sinefungin resistance of Saccharomyces cerevisiae arising from Sam3 mutations that inactivate the AdoMet transporter or from increased expression of AdoMet synthase plus mRNA cap guanine-N7 methyltransferase." Nucleic Acids Res. 35(20):6895-6903. PMID:17932050
  2. [ + ] Davierwala AP, et al. (2005) "The synthetic genetic interaction spectrum of essential genes." Nat Genet. 37(10):1147-1152. PMID:16155567
  3. [ + ] Lindstrom DL, et al. (2003) "Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins." Mol Cell Biol. 23(4):1368-1378. PMID:12556496
  4. [ + ] Gavin AC, et al. (2002) "Functional organization of the yeast proteome by systematic analysis of protein complexes." Nature. 415(6868):141-147. PMID:11805826
  5. [ + ] Schroeder SC, et al. (2000) "Dynamic association of capping enzymes with transcribing RNA polymerase II." Genes Dev. 14(19):2435-2440. PMID:11018011
  6. [ + ] Schwer B, et al. (2000) "Structure-function analysis of yeast mRNA cap methyltransferase and high-copy suppression of conditional mutants by AdoMet synthase and the ubiquitin conjugating enzyme Cdc34p." Genetics. 155(4):1561-1576. PMID:10924457
  7. [ + ] McCracken S, et al. (1997) "5'-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II." Genes Dev. 11(24):3306-3318. PMID:9407024
  8. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  9. [ + ] Mao X, et al. (1995) "Yeast mRNA cap methyltransferase is a 50-kilodalton protein encoded by an essential gene." Mol Cell Biol. 15(8):4167-4174. PMID:7623811
  10. [ + ] Feldmann H, et al. (1994) "Complete DNA sequence of yeast chromosome II." EMBO J. 13(24):5795-5809. PMID:7813418