AAC3 | GeneID:852380 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 852380 Official Symbol AAC3
Locus YBR085W Gene Type protein-coding
Synonyms ANC3
Full Name N/A
Description Aac3p
Chromosome N/A
Also Known As Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 37448

ID Symbol Protein Species
GeneID:828955 AAC3 NP_194568.1 Arabidopsis thaliana
GeneID:852250 PET9 NP_009523.1 Saccharomyces cerevisiae
GeneID:852380 AAC3 NP_009642.1 Saccharomyces cerevisiae
GeneID:2540900 anc1 NP_595323.1 Schizosaccharomyces pombe
GeneID:2684829 MGG_06656 XP_370159.2 Magnaporthe grisea
GeneID:2711737 NCU09477.1 XP_329836.1 Neurospora crassa
GeneID:2894290 ADT_KLULA XP_454505.1 Kluyveromyces lactis
GeneID:4338353 Os05g0302700 NP_001055139.1 Oryza sativa
GeneID:4621250 AGOS_AER184W NP_985041.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0016021 Component integral to membrane
GO:0016020 Component membrane
GO:0005743 Component mitochondrial inner membrane
GO:0005739 Component mitochondrion
GO:0005471 Function ATP:ADP antiporter activity
GO:0005488 Function binding
GO:0005215 Function transporter activity
GO:0009061 Process anaerobic respiration
GO:0043284 Process biopolymer biosynthetic process
GO:0006783 Process heme biosynthetic process
GO:0006417 Process regulation of translation
GO:0006412 Process translation
GO:0055085 Process transmembrane transport
GO:0006810 Process transport

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

A36582   AAA97485   CAA85031   NP_009642   P18238  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ATG12 ATG12 / AAC3 Affinity Capture-MS Ho Y (2002)
BUD32 BUD32 / AAC3 Affinity Capture-MS Ho Y (2002)
HAP2 HAP2 / AAC3 Affinity Capture-MS Ho Y (2002)
LAS17 LAS17 / AAC3 Affinity Capture-MS Ho Y (2002)
LEU5 LEU5 / AAC3 Two-hybrid Miller JP (2005)
N/A N/A / AAC3 Two-hybrid Miller JP (2005)
PET9 PET9 / AAC3 Dosage Rescue Chen XJ (2004)
PMR1 PMR1 / AAC3 Affinity Capture-MS Krogan NJ (2006)
RAD3 RAD3 / AAC3 Affinity Capture-MS Ho Y (2002)
RAD59 RAD59 / AAC3 Affinity Capture-MS Ho Y (2002)
RFA3 RFA3 / AAC3 Affinity Capture-MS Ho Y (2002)
SAC6 AAC3 / SAC6 Synthetic Lethality Vinh DB (1993)
SKP1 SKP1 / AAC3 Affinity Capture-MS Tagwerker C (2006)
SML1 SML1 / AAC3 Affinity Capture-MS Ho Y (2002)
SPT2 SPT2 / AAC3 Affinity Capture-MS Ho Y (2002)
YCK1 YCK1 / AAC3 Affinity Capture-MS Ho Y (2002)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Azuma M, et al. (2008) "Adenine nucleotide translocator transports haem precursors into mitochondria." PLoS ONE. 3(8):e3070. PMID:18728780
  2. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  3. [ + ] Reinders J, et al. (2006) "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." J Proteome Res. 5(7):1543-1554. PMID:16823961
  4. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  5. [ + ] Tagwerker C, et al. (2006) "A tandem affinity tag for two-step purification under fully denaturing conditions: application in ubiquitin profiling and protein complex identification combined with in vivocross-linking." Mol Cell Proteomics. 5(4):737-748. PMID:16432255
  6. [ + ] Miller JP, et al. (2005) "Large-scale identification of yeast integral membrane protein interactions." Proc Natl Acad Sci U S A. 102(34):12123-12128. PMID:16093310
  7. [ + ] Chen XJ, et al. (2004) "Sal1p, a calcium-dependent carrier protein that suppresses an essential cellular function associated With the Aac2 isoform of ADP/ATP translocase in Saccharomyces cerevisiae." Genetics. 167(2):607-617. PMID:15238515
  8. [ + ] Ho Y, et al. (2002) "Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry." Nature. 415(6868):180-183. PMID:11805837
  9. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  10. [ + ] Feldmann H, et al. (1994) "Complete DNA sequence of yeast chromosome II." EMBO J. 13(24):5795-5809. PMID:7813418
  11. [ + ] Vinh DB, et al. (1993) "Genetic evidence for functional interactions between actin noncomplementing (Anc) gene products and actin cytoskeletal proteins in Saccharomyces cerevisiae." Genetics. 135(2):275-286. PMID:8243993
  12. [ + ] Drgon T, et al. (1991) "ADP/ATP translocator is essential only for anaerobic growth of yeast Saccharomyces cerevisiae." FEBS Lett. 289(2):159-162. PMID:1915842
  13. [ + ] Kolarov J, et al. (1990) "A third ADP/ATP translocator gene in yeast." J Biol Chem. 265(21):12711-12716. PMID:2165073