ACH1 | GeneID:852266 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 852266 Official Symbol ACH1
Locus YBL015W Gene Type protein-coding
Synonyms
Full Name N/A
Description Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
Chromosome N/A
Also Known As Ach1p
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 5346

ID Symbol Protein Species
GeneID:852266 ACH1 NP_009538.1 Saccharomyces cerevisiae
GeneID:2542515 SPAC1952.09c NP_594811.1 Schizosaccharomyces pombe
GeneID:2684764 MGG_06609 XP_370094.1 Magnaporthe grisea
GeneID:2712306 NCU09770.1 XP_330420.1 Neurospora crassa
GeneID:2894510 KLLA0E10549g XP_454427.1 Kluyveromyces lactis
GeneID:4621806 AGOS_AFR020W NP_985567.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0005829 Component cytosol
GO:0005739 Component mitochondrion
GO:0008775 Function acetate CoA-transferase activity
GO:0003986 Function acetyl-CoA hydrolase activity
GO:0003824 Function catalytic activity
GO:0016787 Function hydrolase activity
GO:0006083 Process acetate metabolic process
GO:0006084 Process acetyl-CoA metabolic process

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

CAA48570   CAA84834   NP_009538   P32316   S28549  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
AHC1 AHC1 / ACH1 Co-purification Eberharter A (1999)
ARP1 ARP1 / ACH1 Synthetic Lethality Schoner D (2008)
RAD26 RAD26 / ACH1 Affinity Capture-MS Ho Y (2002)
RFC2 RFC2 / ACH1 Affinity Capture-MS Ho Y (2002)
RPC40 RPC40 / ACH1 Affinity Capture-MS Ho Y (2002)
SEN15 SEN15 / ACH1 Affinity Capture-MS Ho Y (2002)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Schoner D, et al. (2008) "Annotating novel genes by integrating synthetic lethals and genomic information." BMC Syst Biol. 2():3. PMID:18194531
  2. [ + ] Reinders J, et al. (2006) "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." J Proteome Res. 5(7):1543-1554. PMID:16823961
  3. [ + ] Buu LM, et al. (2003) "Functional characterization and localization of acetyl-CoA hydrolase, Ach1p, in Saccharomyces cerevisiae." J Biol Chem. 278(19):17203-17209. PMID:12606555
  4. [ + ] Sickmann A, et al. (2003) "The proteome of Saccharomyces cerevisiae mitochondria." Proc Natl Acad Sci U S A. 100(23):13207-13212. PMID:14576278
  5. [ + ] Ho Y, et al. (2002) "Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry." Nature. 415(6868):180-183. PMID:11805837
  6. [ + ] de Nobel H, et al. (2001) "Parallel and comparative analysis of the proteome and transcriptome of sorbic acid-stressed Saccharomyces cerevisiae." Yeast. 18(15):1413-1428. PMID:11746603
  7. [ + ] Eberharter A, et al. (1999) "The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae." Mol Cell Biol. 19(10):6621-6631. PMID:10490601
  8. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  9. [ + ] Lee FJ, et al. (1996) "Acetyl-CoA hydrolase involved in acetate utilization in Saccharomyces cerevisiae." Biochim Biophys Acta. 1297(1):105-109. PMID:8841387
  10. [ + ] Feldmann H, et al. (1994) "Complete DNA sequence of yeast chromosome II." EMBO J. 13(24):5795-5809. PMID:7813418