AAR2 | GeneID:852205 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 852205 Official Symbol AAR2
Locus YBL074C Gene Type protein-coding
Synonyms
Full Name N/A
Description Aar2p
Chromosome N/A
Also Known As Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 38351

ID Symbol Protein Species
GeneID:852205 AAR2 NP_009479.1 Saccharomyces cerevisiae
GeneID:2894678 KLLA0E20581g XP_454877.1 Kluyveromyces lactis
GeneID:4623346 AGOS_AGR376W NP_987042.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0005634 Component nucleus
GO:0005682 Component snRNP U5
GO:0003674 Function molecular_function
GO:0000244 Process assembly of spliceosomal tri-snRNP
GO:0006397 Process mRNA processing
GO:0006417 Process regulation of translation
GO:0008380 Process RNA splicing

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

BAA14421   CAA81524   CAA84894   NP_009479   P32357   S18510  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
AAR2 AAR2 / AAR2 Affinity Capture-MS Krogan NJ (2004)
BRR2 AAR2 / BRR2 Affinity Capture-MS Collins SR (2007)
GCN2 GCN2 / AAR2 Affinity Capture-MS Gavin AC (2002)
GCN2 GCN2 / AAR2 Affinity Capture-MS Gavin AC (2006)
KAP95 AAR2 / KAP95 Affinity Capture-MS Krogan NJ (2006)
NHP2 NHP2 / AAR2 Affinity Capture-MS Gavin AC (2002)
PRP4 AAR2 / PRP4 Affinity Capture-MS Collins SR (2007)
PRP6 AAR2 / PRP6 Affinity Capture-MS Collins SR (2007)
PRP8 PRP8 / AAR2 Affinity Capture-MS Boon KL (2006)
PRP8 AAR2 / PRP8 Affinity Capture-MS Collins SR (2007)
PRP8 PRP8 / AAR2 Affinity Capture-MS Gavin AC (2002)
PRP8 PRP8 / AAR2 Affinity Capture-MS Gavin AC (2006)
PRP8 AAR2 / PRP8 Affinity Capture-MS Krogan NJ (2006)
PRP8 PRP8 / AAR2 Affinity Capture-Western Boon KL (2006)
PRP8 PRP8 / AAR2 Affinity Capture-Western Boon KL (2007)
PRP8 PRP8 / AAR2 Co-fractionation Boon KL (2006)
PRP8 AAR2 / PRP8 Co-fractionation Gottschalk A (2001)
PRP8 PRP8 / AAR2 Co-localization Boon KL (2007)
PRR2 PRR2 / AAR2 Biochemical Activity Ptacek J (2005)
SMB1 AAR2 / SMB1 Affinity Capture-MS Collins SR (2007)
SMB1 SMB1 / AAR2 Affinity Capture-MS Gavin AC (2006)
SMD1 AAR2 / SMD1 Affinity Capture-MS Collins SR (2007)
SMD1 AAR2 / SMD1 Affinity Capture-MS Krogan NJ (2006)
SMD2 AAR2 / SMD2 Affinity Capture-MS Collins SR (2007)
SMX3 AAR2 / SMX3 Affinity Capture-MS Krogan NJ (2006)
SNU114 AAR2 / SNU114 Affinity Capture-MS Collins SR (2007)
SNU114 SNU114 / AAR2 Affinity Capture-MS Gavin AC (2006)
SNU114 AAR2 / SNU114 Co-fractionation Gottschalk A (2001)
SNU66 AAR2 / SNU66 Affinity Capture-MS Collins SR (2007)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  2. [ + ] Collins SR, et al. (2007) "Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae." Mol Cell Proteomics. 6(3):439-450. PMID:17200106
  3. [ + ] Boon KL, et al. (2007) "prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast." Nat Struct Mol Biol. 14(11):1077-1083. PMID:17934474
  4. [ + ] Boon KL, et al. (2006) "Prp8p dissection reveals domain structure and protein interaction sites." RNA. 12(2):198-205. PMID:16373487
  5. [ + ] Gavin AC, et al. (2006) "Proteome survey reveals modularity of the yeast cell machinery." Nature. 440(7084):631-636. PMID:16429126
  6. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  7. [ + ] Ptacek J, et al. (2005) "Global analysis of protein phosphorylation in yeast." Nature. 438(7068):679-684. PMID:16319894
  8. [ + ] Krogan NJ, et al. (2004) "High-definition macromolecular composition of yeast RNA-processing complexes." Mol Cell. 13(2):225-239. PMID:14759368
  9. [ + ] Gavin AC, et al. (2002) "Functional organization of the yeast proteome by systematic analysis of protein complexes." Nature. 415(6868):141-147. PMID:11805826
  10. [ + ] Gottschalk A, et al. (2001) "The yeast U5 snRNP coisolated with the U1 snRNP has an unexpected protein composition and includes the splicing factor Aar2p." RNA. 7(11):1554-1565. PMID:11720285
  11. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  12. [ + ] Feldmann H, et al. (1994) "Complete DNA sequence of yeast chromosome II." EMBO J. 13(24):5795-5809. PMID:7813418