ADE8 | GeneID:852017 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 852017 Official Symbol ADE8
Locus YDR408C Gene Type protein-coding
Full Name N/A
Description Ade8p
Chromosome N/A
Also Known As Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 38817

ID Symbol Protein Species
GeneID:609892 LOC609892 XP_852333.1 Canis lupus familiaris
GeneID:840010 AT1G31220 NP_174407.1 Arabidopsis thaliana
GeneID:852017 ADE8 NP_010696.1 Saccharomyces cerevisiae
GeneID:2538712 ade5 NP_588565.1 Schizosaccharomyces pombe
GeneID:2707034 NCU00843.1 XP_325023.1 Neurospora crassa
GeneID:2896631 KLLA0A02211g XP_451098.1 Kluyveromyces lactis
GeneID:4338261 Os05g0270800 NP_001055060.1 Oryza sativa
GeneID:4345953 Os08g0500900 NP_001062161.1 Oryza sativa
GeneID:4618719 AGOS_AAR120C NP_982662.1 Eremothecium gossypii
GeneID:5049032 MGG_13813 XP_001404303.1 Magnaporthe grisea

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0005634 Component nucleus
GO:0016742 Function hydroxymethyl-, formyl- and related transferase activity
GO:0008168 Function methyltransferase activity
GO:0004644 Function phosphoribosylglycinamide formyltransferase activity
GO:0016740 Function transferase activity
GO:0046084 Process adenine biosynthetic process
GO:0009058 Process biosynthetic process
GO:0006725 Process cellular aromatic compound metabolic process
GO:0006189 Process 'de novo' IMP biosynthetic process
GO:0006807 Process nitrogen compound metabolic process
GO:0009117 Process nucleotide metabolic process
GO:0006730 Process one-carbon compound metabolic process
GO:0006164 Process purine nucleotide biosynthetic process
GO:0006399 Process tRNA metabolic process

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

1106229A   1409346A   A8BYD   AAA34406   AAB64848   NP_010696   P04161  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ADE2 ADE2 / ADE8 Phenotypic Suppression Zekhnov AM (1998)
BUD31 ADE8 / BUD31 Two-hybrid Uetz P (2000)
MED4 ADE8 / MED4 Two-hybrid Uetz P (2000)
PRT1 ADE8 / PRT1 Affinity Capture-MS Krogan NJ (2006)
SOH1 ADE8 / SOH1 Two-hybrid Uetz P (2000)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  2. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  3. [ + ] Huh WK, et al. (2003) "Global analysis of protein localization in budding yeast." Nature. 425(6959):686-691. PMID:14562095
  4. [ + ] Uetz P, et al. (2000) "A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae." Nature. 403(6770):623-627. PMID:10688190
  5. [ + ] Zekhnov AM, et al. (1998) "[New phenotypic manifestation of the ad2 mutation in Saccharomyces cerevisiae yeast--the inability to grow on a synthetic medium with glycerol and hypoxanthine]" Genetika. 34(2):190-197. PMID:9589850
  6. [ + ] Jacq C, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature. 387(6632 Suppl):75-78. PMID:9169867
  7. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  8. [ + ] Ugolini S, et al. (1996) "The red/white colony color assay in the yeast Saccharomyces cerevisiae: epistatic growth advantage of white ade8-18, ade2 cells over red ade2 cells." Curr Genet. 30(6):485-492. PMID:8939809