ADK1 | GeneID:851812 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 851812 Official Symbol ADK1
Locus YDR226W Gene Type protein-coding
Synonyms AKY1; AKY2
Full Name N/A
Description Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence
Chromosome N/A
Also Known As Adk1p
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 1227

ID Symbol Protein Species
GeneID:204 AK2 NP_001616.1 Homo sapiens
GeneID:11637 Ak2 NP_001029138.1 Mus musculus
GeneID:24184 Ak2 NP_112248.1 Rattus norvegicus
GeneID:37834 Adk2 NP_523836.2 Drosophila melanogaster
GeneID:176118 let-754 NP_498730.1 Caenorhabditis elegans
GeneID:280716 AK2 NP_776314.1 Bos taurus
GeneID:321793 ak2 NP_997761.1 Danio rerio
GeneID:428227 AK2 XP_425786.2 Gallus gallus
GeneID:456723 AK2 XP_001165163.1 Pan troglodytes
GeneID:478145 AK2 XP_535321.2 Canis lupus familiaris
GeneID:810244 PF10_0086 XP_001347371.1 Plasmodium falciparum
GeneID:835104 AT5G50370 NP_199848.1 Arabidopsis thaliana
GeneID:836459 ADK1 NP_201145.1 Arabidopsis thaliana
GeneID:851812 ADK1 NP_010512.1 Saccharomyces cerevisiae
GeneID:1269521 AgaP_AGAP007722 XP_308155.2 Anopheles gambiae
GeneID:2542704 adk1 NP_593685.1 Schizosaccharomyces pombe
GeneID:2674388 MGG_01058 XP_368186.1 Magnaporthe grisea
GeneID:2709914 NCU01550.1 XP_327989.1 Neurospora crassa
GeneID:2896019 KLLA0F13376g XP_455682.1 Kluyveromyces lactis
GeneID:4350358 Os11g0312400 NP_001067759.1 Oryza sativa
GeneID:4351850 Os12g0236400 NP_001066462.1 Oryza sativa
GeneID:4623155 AGOS_AGR187W NP_986853.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0005829 Component cytosol
GO:0005758 Component mitochondrial intermembrane space
GO:0005739 Component mitochondrion
GO:0004017 Function adenylate kinase activity
GO:0005524 Function ATP binding
GO:0016301 Function kinase activity
GO:0019205 Function nucleobase, nucleoside, nucleotide kinase activity
GO:0000166 Function nucleotide binding
GO:0019201 Function nucleotide kinase activity
GO:0016776 Function phosphotransferase activity, phosphate group as acceptor
GO:0016740 Function transferase activity
GO:0006172 Process ADP biosynthetic process
GO:0006139 Process nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GO:0009117 Process nucleotide metabolic process

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

AAA66319   AAC33143   CAA29624   CAA88506   KIBYA   NP_010512   P07170  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
BCK1 BCK1 / ADK1 Biochemical Activity Ptacek J (2005)
CDC14 CDC14 / ADK1 Affinity Capture-MS Ho Y (2002)
DBF2 DBF2 / ADK1 Biochemical Activity Mah AS (2005)
DBF2 DBF2 / ADK1 Biochemical Activity Ptacek J (2005)
INO1 ADK1 / INO1 PCA Tarassov K (2008)
KSP1 KSP1 / ADK1 Biochemical Activity Ptacek J (2005)
N/A N/A / ADK1 Affinity Capture-MS Ho Y (2002)
N/A N/A / ADK1 Affinity Capture-MS Krogan NJ (2006)
PHO85 PHO85 / ADK1 Affinity Capture-MS Ho Y (2002)
PRP11 PRP11 / ADK1 Affinity Capture-MS Ho Y (2002)
RAD53 RAD53 / ADK1 Biochemical Activity Ptacek J (2005)
SKS1 SKS1 / ADK1 Biochemical Activity Ptacek J (2005)
SMT3 SMT3 / ADK1 Affinity Capture-MS Hannich JT (2005)
SPL2 ADK1 / SPL2 Phenotypic Suppression Gauthier S (2008)
TEM1 TEM1 / ADK1 Affinity Capture-MS Ho Y (2002)
UBC1 UBC1 / ADK1 Affinity Capture-MS Ho Y (2002)
URA6 ADK1 / URA6 Dosage Rescue Schricker R (1992)
YCK2 YCK2 / ADK1 Biochemical Activity Ptacek J (2005)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Tarassov K, et al. (2008) "An in vivo map of the yeast protein interactome." Science. 320(5882):1465-1470. PMID:18467557
  2. [ + ] Gauthier S, et al. (2008) "Co-regulation of yeast purine and phosphate pathways in response to adenylic nucleotide variations." Mol Microbiol. 68(6):1583-1594. PMID:18433446
  3. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  4. [ + ] Reinders J, et al. (2006) "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." J Proteome Res. 5(7):1543-1554. PMID:16823961
  5. [ + ] Hannich JT, et al. (2005) "Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae." J Biol Chem. 280(6):4102-4110. PMID:15590687
  6. [ + ] Mah AS, et al. (2005) "Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by peptide library and proteome array screening." BMC Biochem. 6():22. PMID:16242037
  7. [ + ] Ptacek J, et al. (2005) "Global analysis of protein phosphorylation in yeast." Nature. 438(7068):679-684. PMID:16319894
  8. [ + ] Ho Y, et al. (2002) "Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry." Nature. 415(6868):180-183. PMID:11805837
  9. [ + ] Jacq C, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature. 387(6632 Suppl):75-78. PMID:9169867
  10. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  11. [ + ] Schricker R, et al. (1992) "The adenylate kinase family in yeast: identification of URA6 as a multicopy suppressor of deficiency in major AMP kinase." Gene. 122(1):111-118. PMID:1333436
  12. [ + ] Bandlow W, et al. (1988) "Yeast adenylate kinase is active simultaneously in mitochondria and cytoplasm and is required for non-fermentative growth." Eur J Biochem. 178(2):451-457. PMID:2850178
  13. [ + ] Konrad M, et al. (1988) "Analysis and in vivo disruption of the gene coding for adenylate kinase (ADK1) in the yeast Saccharomyces cerevisiae." J Biol Chem. 263(36):19468-19474. PMID:2848829