ADR1 | GeneID:851802 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 851802 Official Symbol ADR1
Locus YDR216W Gene Type protein-coding
Synonyms
Full Name N/A
Description Adr1p
Chromosome N/A
Also Known As Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 38728

ID Symbol Protein Species
GeneID:851802 ADR1 NP_010502.1 Saccharomyces cerevisiae
GeneID:2895960 KLLA0F13046g XP_455667.1 Kluyveromyces lactis
GeneID:4623140 AGOS_AGR172W NP_986838.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005622 Component intracellular
GO:0005634 Component nucleus
GO:0003677 Function DNA binding
GO:0046872 Function metal ion binding
GO:0003676 Function nucleic acid binding
GO:0043565 Function sequence-specific DNA binding
GO:0003700 Function transcription factor activity
GO:0008270 Function zinc ion binding
GO:0000433 Process negative regulation of transcription from RNA polymerase II promoter by glucose
GO:0007031 Process peroxisome organization
GO:0006109 Process regulation of carbohydrate metabolic process
GO:0006355 Process regulation of transcription, DNA-dependent
GO:0034201 Process response to oleic acid
GO:0006350 Process transcription

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

1204267A   A24534   NP_010502   P07248  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ADA2 ADR1 / ADA2 Affinity Capture-Western Chiang YC (1996)
ADH2 ADH2 / ADR1 Phenotypic Enhancement Denis CL (1987)
ARP2 ARP2 / ADR1 Affinity Capture-MS Ho Y (2002)
BMH1 BMH1 / ADR1 Affinity Capture-MS Ho Y (2002)
CAT8 ADR1 / CAT8 Co-localization Tachibana C (2005)
CAT8 CAT8 / ADR1 Phenotypic Enhancement Walther K (2001)
CNS1 CNS1 / ADR1 Two-hybrid Millson SH (2004)
COP1 COP1 / ADR1 Affinity Capture-MS Ho Y (2002)
GCN5 ADR1 / GCN5 Affinity Capture-Western Chiang YC (1996)
HDA1 ADR1 / HDA1 Phenotypic Enhancement Tachibana C (2007)
HRT1 HRT1 / ADR1 Affinity Capture-MS Ho Y (2002)
HSP82 HSP82 / ADR1 Two-hybrid Zhao R (2005)
KAP104 KAP104 / ADR1 Affinity Capture-MS Ho Y (2002)
PIP2 ADR1 / PIP2 Dosage Rescue Rottensteiner H (2003)
PPT1 PPT1 / ADR1 Two-hybrid Uetz P (2000)
REG1 ADR1 / REG1 Phenotypic Enhancement Dombek KM (1993)
REG1 ADR1 / REG1 Phenotypic Enhancement Tachibana C (2007)
RML2 RML2 / ADR1 Dosage Rescue Hagerman RA (2001)
RPC40 RPC40 / ADR1 Affinity Capture-MS Ho Y (2002)
RPD3 ADR1 / RPD3 Phenotypic Enhancement Tachibana C (2007)
SBA1 SBA1 / ADR1 Two-hybrid Millson SH (2004)
SHO1 SHO1 / ADR1 Two-hybrid Tong AH (2002)
SNF1 ADR1 / SNF1 Co-localization Young ET (2002)
SNF1 SNF1 / ADR1 Dosage Rescue Denis CL (1987)
SNF1 ADR1 / SNF1 Synthetic Rescue Denis CL (1984)
SNF1 ADR1 / SNF1 Synthetic Rescue Denis CL (1986)
SPT15 ADR1 / SPT15 Affinity Capture-Western Komarnitsky PB (1998)
SUA7 ADR1 / SUA7 Affinity Capture-Western Chiang YC (1996)
TAF1 ADR1 / TAF1 Affinity Capture-Western Komarnitsky PB (1998)
TAF10 ADR1 / TAF10 Affinity Capture-Western Komarnitsky PB (1998)
TAF5 TAF5 / ADR1 Affinity Capture-Western Komarnitsky PB (1998)
TAF6 ADR1 / TAF6 Affinity Capture-Western Komarnitsky PB (1998)
YKU80 YKU80 / ADR1 Affinity Capture-MS Ho Y (2002)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Biddick RK, et al. (2008) "Adr1 and Cat8 mediate coactivator recruitment and chromatin remodeling at glucose-regulated genes." PLoS ONE. 3(1):e1436. PMID:18197247
  2. [ + ] Young ET, et al. (2008) "Artificial recruitment of mediator by the DNA-binding domain of Adr1 overcomes glucose repression of ADH2 expression." Mol Cell Biol. 28(8):2509-2516. PMID:18250152
  3. [ + ] Smith JJ, et al. (2007) "Transcriptional responses to fatty acid are coordinated by combinatorial control." Mol Syst Biol. 3():115. PMID:17551510
  4. [ + ] Tachibana C, et al. (2007) "A poised initiation complex is activated by SNF1." J Biol Chem. 282(52):37308-37315. PMID:17974563
  5. [ + ] Tachibana C, et al. (2005) "Combined global localization analysis and transcriptome data identify genes that are directly coregulated by Adr1 and Cat8." Mol Cell Biol. 25(6):2138-2146. PMID:15743812
  6. [ + ] Zhao R, et al. (2005) "Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone." Cell. 120(5):715-727. PMID:15766533
  7. [ + ] Millson SH, et al. (2004) "Investigating the protein-protein interactions of the yeast Hsp90 chaperone system by two-hybrid analysis: potential uses and limitations of this approach." Cell Stress Chaperones. 9(4):359-368. PMID:15633294
  8. [ + ] Rottensteiner H, et al. (2003) "Saccharomyces cerevisiae PIP2 mediating oleic acid induction and peroxisome proliferation is regulated by Adr1p and Pip2p-Oaf1p." J Biol Chem. 278(30):27605-27611. PMID:12748191
  9. [ + ] Young ET, et al. (2003) "Multiple pathways are co-regulated by the protein kinase Snf1 and the transcription factors Adr1 and Cat8." J Biol Chem. 278(28):26146-26158. PMID:12676948
  10. [ + ] Young ET, et al. (2002) "Snf1 protein kinase regulates Adr1 binding to chromatin but not transcription activation." J Biol Chem. 277(41):38095-38103. PMID:12167649
  11. [ + ] Ho Y, et al. (2002) "Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry." Nature. 415(6868):180-183. PMID:11805837
  12. [ + ] Tong AH, et al. (2002) "A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules." Science. 295(5553):321-324. PMID:11743162
  13. [ + ] Hagerman RA, et al. (2001) "A mutation in the yeast mitochondrial ribosomal protein Rml2p is associated with a defect in catalase gene expression." Mol Cell Biol Res Commun. 4(5):299-306. PMID:11529680
  14. [ + ] Gurvitz A, et al. (2001) "Saccharomyces cerevisiae Adr1p governs fatty acid beta-oxidation and peroxisome proliferation by regulating POX1 and PEX11." J Biol Chem. 276(34):31825-31830. PMID:11431484
  15. [ + ] Walther K, et al. (2001) "Adr1 and Cat8 synergistically activate the glucose-regulated alcohol dehydrogenase gene ADH2 of the yeast Saccharomyces cerevisiae." Microbiology. 147(Pt 8):2037-2044. PMID:11495982
  16. [ + ] Uetz P, et al. (2000) "A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae." Nature. 403(6770):623-627. PMID:10688190
  17. [ + ] Sloan JS, et al. (1999) "Post-translational regulation of Adr1 activity is mediated by its DNA binding domain." J Biol Chem. 274(53):37575-37582. PMID:10608811
  18. [ + ] Komarnitsky PB, et al. (1998) "ADR1-mediated transcriptional activation requires the presence of an intact TFIID complex." Mol Cell Biol. 18(10):5861-5867. PMID:9742103
  19. [ + ] Jacq C, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature. 387(6632 Suppl):75-78. PMID:9169867
  20. [ + ] Chiang YC, et al. (1996) "ADR1 activation domains contact the histone acetyltransferase GCN5 and the core transcriptional factor TFIIB." J Biol Chem. 271(50):32359-32365. PMID:8943299
  21. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  22. [ + ] Dombek KM, et al. (1993) "ADH2 expression is repressed by REG1 independently of mutations that alter the phosphorylation of the yeast transcription factor ADR1." Mol Cell Biol. 13(7):4391-4399. PMID:8321238
  23. [ + ] Denis CL, et al. (1987) "The effects of ADR1 and CCR1 gene dosage on the regulation of the glucose-repressible alcohol dehydrogenase from Saccharomyces cerevisiae." Mol Gen Genet. 208(1-2):101-106. PMID:3302603
  24. [ + ] Denis CL, et al. (1986) "Constitutive RNA synthesis for the yeast activator ADR1 and identification of the ADR1-5c mutation: implications in posttranslational control of ADR1." Mol Cell Biol. 6(11):4026-4030. PMID:3540604
  25. [ + ] Denis CL, et al. (1984) "Identification of new genes involved in the regulation of yeast alcohol dehydrogenase II." Genetics. 108(4):833-844. PMID:6392016