ADY3 | GeneID:851359 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 851359 Official Symbol ADY3
Locus YDL239C Gene Type protein-coding
Synonyms
Full Name N/A
Description Ady3p
Chromosome N/A
Also Known As Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 68613

ID Symbol Protein Species
GeneID:851359 ADY3 NP_010042.1 Saccharomyces cerevisiae
GeneID:2893212 KLLA0D19580g XP_453931.1 Kluyveromyces lactis
GeneID:4618833 AGOS_ABL193C NP_982754.2 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0016020 Component membrane
GO:0005634 Component nucleus
GO:0005628 Component prospore membrane
GO:0005819 Component spindle
GO:0005816 Component spindle pole body
GO:0005515 Function protein binding
GO:0030476 Process ascospore wall assembly
GO:0006914 Process autophagy
GO:0007049 Process cell cycle
GO:0051301 Process cell division
GO:0007126 Process meiosis
GO:0000001 Process mitochondrion inheritance
GO:0006461 Process protein complex assembly
GO:0030435 Process sporulation resulting in formation of a cellular spore
GO:0007039 Process vacuolar protein catabolic process

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

CAA98819   NP_010042   Q07732   S67803  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ATG17 ADY3 / ATG17 Two-hybrid Ito T (2001)
BBP1 ADY3 / BBP1 Two-hybrid Ito T (2001)
CAT2 ADY3 / CAT2 Two-hybrid Ito T (2001)
CDC28 CDC28 / ADY3 Biochemical Activity Ubersax JA (2003)
CHA4 ADY3 / CHA4 Two-hybrid Uetz P (2000)
CLB2 CLB2 / ADY3 Biochemical Activity Ubersax JA (2003)
CNM67 ADY3 / CNM67 Two-hybrid Moreno-Borchart AC (2001)
CNM67 ADY3 / CNM67 Two-hybrid Nickas ME (2002)
DON1 ADY3 / DON1 Two-hybrid Ito T (2001)
FRT1 ADY3 / FRT1 Two-hybrid Ito T (2001)
FRT2 ADY3 / FRT2 Two-hybrid Ito T (2001)
GIP1 ADY3 / GIP1 Phenotypic Enhancement Suda Y (2007)
HSC82 HSC82 / ADY3 Synthetic Growth Defect McClellan AJ (2007)
HSP26 ADY3 / HSP26 Two-hybrid Ito T (2001)
HSP82 HSP82 / ADY3 Synthetic Growth Defect McClellan AJ (2007)
HSP82 HSP82 / ADY3 Two-hybrid Zhao R (2005)
HUA1 ADY3 / HUA1 Two-hybrid Ito T (2001)
KGD2 ADY3 / KGD2 Two-hybrid Ito T (2001)
LAP4 ADY3 / LAP4 Two-hybrid Ito T (2001)
MPC54 MPC54 / ADY3 Affinity Capture-MS Moreno-Borchart AC (2001)
MPC54 ADY3 / MPC54 Two-hybrid Moreno-Borchart AC (2001)
MPS2 MPS2 / ADY3 Two-hybrid Wong J (2007)
MUK1 ADY3 / MUK1 Two-hybrid Ito T (2001)
N/A ADY3 / N/A Two-hybrid Ito T (2001)
NGG1 NGG1 / ADY3 Two-hybrid Ito T (2001)
NUD1 ADY3 / NUD1 Two-hybrid Moreno-Borchart AC (2001)
NUD1 ADY3 / NUD1 Two-hybrid Nickas ME (2002)
NUF2 NUF2 / ADY3 Two-hybrid Wong J (2007)
PDB1 PDB1 / ADY3 Affinity Capture-MS Krogan NJ (2006)
SLI15 SLI15 / ADY3 Two-hybrid Wong J (2007)
SPC19 SPC19 / ADY3 Two-hybrid Wong J (2007)
SPC24 SPC24 / ADY3 Two-hybrid Wong J (2007)
SPC29 ADY3 / SPC29 Two-hybrid Ito T (2001)
SPC42 ADY3 / SPC42 Two-hybrid Nickas ME (2002)
SPO21 ADY3 / SPO21 Two-hybrid Moreno-Borchart AC (2001)
SPO21 ADY3 / SPO21 Two-hybrid Nickas ME (2002)
SPO21 ADY3 / SPO21 Two-hybrid Uetz P (2000)
SSP1 ADY3 / SSP1 Co-localization Moreno-Borchart AC (2001)
SSP1 ADY3 / SSP1 Two-hybrid Ito T (2001)
SSP1 SSP1 / ADY3 Two-hybrid Maier P (2007)
SSP1 ADY3 / SSP1 Two-hybrid Moreno-Borchart AC (2001)
SSP1 ADY3 / SSP1 Two-hybrid Uetz P (2000)
TID3 TID3 / ADY3 Two-hybrid Wong J (2007)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  2. [ + ] McClellan AJ, et al. (2007) "Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches." Cell. 131(1):121-135. PMID:17923092
  3. [ + ] Suda Y, et al. (2007) "Alternative modes of organellar segregation during sporulation in Saccharomyces cerevisiae." Eukaryot Cell. 6(11):2009-2017. PMID:17905927
  4. [ + ] Wong J, et al. (2007) "A protein interaction map of the mitotic spindle." Mol Biol Cell. 18(10):3800-3809. PMID:17634282
  5. [ + ] Maier P, et al. (2007) "Cytokinesis in yeast meiosis depends on the regulated removal of Ssp1p from the prospore membrane." EMBO J. 26(7):1843-1852. PMID:17347652
  6. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  7. [ + ] Zhao R, et al. (2005) "Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone." Cell. 120(5):715-727. PMID:15766533
  8. [ + ] Ubersax JA, et al. (2003) "Targets of the cyclin-dependent kinase Cdk1." Nature. 425(6960):859-864. PMID:14574415
  9. [ + ] Nickas ME, et al. (2002) "Ady3p links spindle pole body function to spore wall synthesis in Saccharomyces cerevisiae." Genetics. 160(4):1439-1450. PMID:11973299
  10. [ + ] Moreno-Borchart AC, et al. (2001) "Prospore membrane formation linked to the leading edge protein (LEP) coat assembly." EMBO J. 20(24):6946-6957. PMID:11742972
  11. [ + ] Rabitsch KP, et al. (2001) "A screen for genes required for meiosis and spore formation based on whole-genome expression." Curr Biol. 11(13):1001-1009. PMID:11470404
  12. [ + ] Ito T, et al. (2001) "A comprehensive two-hybrid analysis to explore the yeast protein interactome." Proc Natl Acad Sci U S A. 98(8):4569-4574. PMID:11283351
  13. [ + ] Uetz P, et al. (2000) "A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae." Nature. 403(6770):623-627. PMID:10688190
  14. [ + ] Jacq C, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature. 387(6632 Suppl):75-78. PMID:9169867
  15. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441