ADE1 | GeneID:851272 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 851272 Official Symbol ADE1
Locus YAR015W Gene Type protein-coding
Full Name N/A
Description Ade1p
Chromosome N/A
Also Known As N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 38333

ID Symbol Protein Species
GeneID:821663 PUR7 NP_001030739.1 Arabidopsis thaliana
GeneID:851272 ADE1 NP_009409.1 Saccharomyces cerevisiae
GeneID:2541029 ade7 NP_595460.1 Schizosaccharomyces pombe
GeneID:2712561 NCU03166.1 XP_330602.1 Neurospora crassa
GeneID:2892265 KLLA0C04235g XP_452386.1 Kluyveromyces lactis
GeneID:4347318 Os09g0467100 NP_001063422.1 Oryza sativa
GeneID:4621288 AGOS_AER221W NP_985078.1 Eremothecium gossypii
GeneID:5050423 MGG_12537 XP_001409748.1 Magnaporthe grisea

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0005634 Component nucleus
GO:0005524 Function ATP binding
GO:0003824 Function catalytic activity
GO:0016874 Function ligase activity
GO:0000166 Function nucleotide binding
GO:0004639 Function phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO:0043094 Process cellular metabolic compound salvage
GO:0006189 Process 'de novo' IMP biosynthetic process
GO:0018193 Process peptidyl-amino acid modification
GO:0006164 Process purine nucleotide biosynthetic process
GO:0006417 Process regulation of translation
GO:0042493 Process response to drug
GO:0042254 Process ribosome biogenesis
GO:0009451 Process RNA modification
GO:0016072 Process rRNA metabolic process
GO:0019748 Process secondary metabolic process

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
GCD7 GCD7 / ADE1 Affinity Capture-MS Krogan NJ (2006)
HSC82 HSC82 / ADE1 Synthetic Growth Defect McClellan AJ (2007)
HSP82 HSP82 / ADE1 Affinity Capture-MS Zhao R (2005)
HSP82 HSP82 / ADE1 Synthetic Growth Defect McClellan AJ (2007)
HSP82 HSP82 / ADE1 Two-hybrid Zhao R (2005)
KSP1 KSP1 / ADE1 Biochemical Activity Ptacek J (2005)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  2. [ + ] McClellan AJ, et al. (2007) "Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches." Cell. 131(1):121-135. PMID:17923092
  3. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  4. [ + ] Zhao R, et al. (2005) "Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone." Cell. 120(5):715-727. PMID:15766533
  5. [ + ] Dilda PJ, et al. (2005) "Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains." J Natl Cancer Inst. 97(20):1539-1547. PMID:16234568
  6. [ + ] Ptacek J, et al. (2005) "Global analysis of protein phosphorylation in yeast." Nature. 438(7068):679-684. PMID:16319894
  7. [ + ] Huh WK, et al. (2003) "Global analysis of protein localization in budding yeast." Nature. 425(6959):686-691. PMID:14562095
  8. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  9. [ + ] Bussey H, et al. (1995) "The nucleotide sequence of chromosome I from Saccharomyces cerevisiae." Proc Natl Acad Sci U S A. 92(9):3809-3813. PMID:7731988
  10. [ + ] Myasnikov AN, et al. (1991) "The Saccharomyces cerevisiae ADE1 gene: structure, overexpression and possible regulation by general amino acid control." Gene. 109(1):143-147. PMID:1756975
  11. [ + ] Fisher CR, et al. (1969) "Enzymology of the pigmented adenine-requiring mutants of Saccharomyces and Schizosaccharomyces." Biochem Biophys Res Commun. 34(3):306-310. PMID:5767025
  12. [ + ] Silver JM, et al. (1969) "Functional blocks of the ad-1 and ad-2 mutants of Saccharomyces cerevisiae." Biochem Biophys Res Commun. 34(3):301-305. PMID:5767024