ACS1 | GeneID:851245 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 851245 Official Symbol ACS1
Locus YAL054C Gene Type protein-coding
Synonyms FUN44
Full Name N/A
Description Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
Chromosome N/A
Also Known As Acs1p
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 56037

ID Symbol Protein Species
GeneID:68738 Acss1 NP_542142.1 Mus musculus
GeneID:84532 ACSS1 NP_115890.2 Homo sapiens
GeneID:282873 ACSS1 NP_777171.1 Bos taurus
GeneID:296259 Acss1 XP_215897.4 Rattus norvegicus
GeneID:416714 ACSS1 XP_415011.2 Gallus gallus
GeneID:469905 ACSS1 XP_001149851.1 Pan troglodytes
GeneID:477002 ACSS1 XP_534200.2 Canis lupus familiaris
GeneID:791174 zgc:158738 NP_001074125.2 Danio rerio
GeneID:851245 ACS1 NP_009347.1 Saccharomyces cerevisiae
GeneID:2896335 ACS1_KLULA XP_451146.1 Kluyveromyces lactis
GeneID:4620668 AGOS_ADR408W NP_984503.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005829 Component cytosol
GO:0005783 Component endoplasmic reticulum
GO:0005792 Component microsome
GO:0005739 Component mitochondrion
GO:0003987 Function acetate-CoA ligase activity
GO:0016208 Function AMP binding
GO:0005524 Function ATP binding
GO:0003824 Function catalytic activity
GO:0016874 Function ligase activity
GO:0000166 Function nucleotide binding
GO:0019654 Process acetate fermentation
GO:0006085 Process acetyl-CoA biosynthetic process
GO:0016573 Process histone acetylation
GO:0008152 Process metabolic process

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
N/A N/A / ACS1 Two-hybrid Ito T (2001)
SRP1 SRP1 / ACS1 Two-hybrid Ito T (2001)
YAT1 ACS1 / YAT1 PCA Tarassov K (2008)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Tarassov K, et al. (2008) "An in vivo map of the yeast protein interactome." Science. 320(5882):1465-1470. PMID:18467557
  2. [ + ] Takahashi H, et al. (2006) "Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription." Mol Cell. 23(2):207-217. PMID:16857587
  3. [ + ] Reinders J, et al. (2006) "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." J Proteome Res. 5(7):1543-1554. PMID:16823961
  4. [ + ] Sickmann A, et al. (2003) "The proteome of Saccharomyces cerevisiae mitochondria." Proc Natl Acad Sci U S A. 100(23):13207-13212. PMID:14576278
  5. [ + ] Ito T, et al. (2001) "A comprehensive two-hybrid analysis to explore the yeast protein interactome." Proc Natl Acad Sci U S A. 98(8):4569-4574. PMID:11283351
  6. [ + ] de Jong-Gubbels P, et al. (1998) "Overproduction of acetyl-coenzyme A synthetase isoenzymes in respiring Saccharomyces cerevisiae cells does not reduce acetate production after exposure to glucose excess." FEMS Microbiol Lett. 165(1):15-20. PMID:9711835
  7. [ + ] van den Berg MA, et al. (1996) "The two acetyl-coenzyme A synthetases of Saccharomyces cerevisiae differ with respect to kinetic properties and transcriptional regulation." J Biol Chem. 271(46):28953-28959. PMID:8910545
  8. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  9. [ + ] Bussey H, et al. (1995) "The nucleotide sequence of chromosome I from Saccharomyces cerevisiae." Proc Natl Acad Sci U S A. 92(9):3809-3813. PMID:7731988
  10. [ + ] De Virgilio C, et al. (1992) "Cloning and disruption of a gene required for growth on acetate but not on ethanol: the acetyl-coenzyme A synthetase gene of Saccharomyces cerevisiae." Yeast. 8(12):1043-1051. PMID:1363452