AFG2 | GeneID:851113 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 851113 Official Symbol AFG2
Locus YLR397C Gene Type protein-coding
Synonyms DRG1
Full Name N/A
Description ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; may be involved in degradation of aberrant mRNAs
Chromosome N/A
Also Known As Afg2p
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 56920

ID Symbol Protein Species
GeneID:34680 CG5776 NP_609585.1 Drosophila melanogaster
GeneID:57815 Spata5 NP_067318.1 Mus musculus
GeneID:166378 SPATA5 NP_660208.2 Homo sapiens
GeneID:361935 Spata5 XP_342236.2 Rattus norvegicus
GeneID:422665 SPATA5 XP_420619.2 Gallus gallus
GeneID:461474 SPATA5 XP_517427.2 Pan troglodytes
GeneID:483840 SPATA5 XP_540960.2 Canis lupus familiaris
GeneID:561779 LOC561779 XP_690281.3 Danio rerio
GeneID:782646 SPATA5 XP_001251283.1 Bos taurus
GeneID:824836 CIP111 NP_191228.1 Arabidopsis thaliana
GeneID:851113 AFG2 NP_013501.1 Saccharomyces cerevisiae
GeneID:2540537 SPBC56F2.07c NP_596710.1 Schizosaccharomyces pombe
GeneID:2897140 KLLA0B03234g XP_451677.1 Kluyveromyces lactis

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005622 Component intracellular
GO:0016887 Function ATPase activity
GO:0005524 Function ATP binding
GO:0017111 Function nucleoside-triphosphatase activity
GO:0000166 Function nucleotide binding
GO:0042493 Process response to drug

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

AAB82355   AAC37367   AAT93135   NP_013501   P32794   S39110  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
AFG2 AFG2 / AFG2 PCA Tarassov K (2008)
ARX1 ARX1 / AFG2 Affinity Capture-Western Pertschy B (2007)
BUD20 BUD20 / AFG2 Affinity Capture-MS Ho Y (2002)
DSS4 DSS4 / AFG2 Affinity Capture-MS Ho Y (2002)
N/A N/A / AFG2 Affinity Capture-Western Pertschy B (2007)
PTK2 PTK2 / AFG2 Biochemical Activity Ptacek J (2005)
SWH1 SWH1 / AFG2 Affinity Capture-MS Gavin AC (2002)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Tarassov K, et al. (2008) "An in vivo map of the yeast protein interactome." Science. 320(5882):1465-1470. PMID:18467557
  2. [ + ] Pertschy B, et al. (2007) "Cytoplasmic recycling of 60S preribosomal factors depends on the AAA protein Drg1." Mol Cell Biol. 27(19):6581-6592. PMID:17646390
  3. [ + ] Ptacek J, et al. (2005) "Global analysis of protein phosphorylation in yeast." Nature. 438(7068):679-684. PMID:16319894
  4. [ + ] Ho Y, et al. (2002) "Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry." Nature. 415(6868):180-183. PMID:11805837
  5. [ + ] Gavin AC, et al. (2002) "Functional organization of the yeast proteome by systematic analysis of protein complexes." Nature. 415(6868):141-147. PMID:11805826
  6. [ + ] Zakalskiy A, et al. (2002) "Structural and enzymatic properties of the AAA protein Drg1p from Saccharomyces cerevisiae. Decoupling of intracellular function from ATPase activity and hexamerization." J Biol Chem. 277(30):26788-26795. PMID:12006565
  7. [ + ] Wendler F, et al. (1997) "Diazaborine resistance in the yeast Saccharomyces cerevisiae reveals a link between YAP1 and the pleiotropic drug resistance genes PDR1 and PDR3." J Biol Chem. 272(43):27091-27098. PMID:9341149
  8. [ + ] Johnston M, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Nature. 387(6632 Suppl):87-90. PMID:9169871
  9. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441