ADE13 | GeneID:851073 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 851073 Official Symbol ADE13
Locus YLR359W Gene Type protein-coding
Synonyms BRA1; BRA8
Full Name N/A
Description Ade13p
Chromosome N/A
Also Known As Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 12

ID Symbol Protein Species
GeneID:158 ADSL NP_000017.1 Homo sapiens
GeneID:11564 Adsl NP_033764.2 Mus musculus
GeneID:42051 CG3590 NP_650586.2 Drosophila melanogaster
GeneID:315150 Adsl XP_235496.3 Rattus norvegicus
GeneID:334431 adsl NP_956193.1 Danio rerio
GeneID:396540 ADSL NP_990860.1 Gallus gallus
GeneID:474499 ADSL XP_531727.2 Canis lupus familiaris
GeneID:510949 ADSL XP_873445.1 Bos taurus
GeneID:851073 ADE13 NP_013463.1 Saccharomyces cerevisiae
GeneID:1273584 AgaP_AGAP002378 XP_312577.2 Anopheles gambiae
GeneID:2539985 ade8 NP_596735.1 Schizosaccharomyces pombe
GeneID:2676630 MGG_03645 XP_361102.2 Magnaporthe grisea
GeneID:2707944 NCU06187.1 XP_326042.1 Neurospora crassa
GeneID:2897031 KLLA0B13189g XP_452119.1 Kluyveromyces lactis
GeneID:4619033 AGOS_ABL006C NP_982941.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005575 Component cellular_component
GO:0003824 Function catalytic activity
GO:0016829 Function lyase activity
GO:0004018 Function N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
GO:0070626 Function (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity
GO:0006189 Process 'de novo' IMP biosynthetic process
GO:0006164 Process purine nucleotide biosynthetic process
GO:0009152 Process purine ribonucleotide biosynthetic process

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

AAB67573   NP_013463   Q05911   S51377  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ACB1 ACB1 / ADE13 Affinity Capture-MS Krogan NJ (2006)
ADE2 ADE13 / ADE2 Synthetic Rescue Zekhnov AM (2000)
ADE4 ADE13 / ADE4 Dosage Lethality Rebora K (2005)
PPS1 PPS1 / ADE13 Affinity Capture-MS Ho Y (2002)
PRT1 ADE13 / PRT1 Affinity Capture-MS Gavin AC (2002)
SEH1 SEH1 / ADE13 Affinity Capture-MS Ho Y (2002)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  2. [ + ] Rebora K, et al. (2005) "Revisiting purine-histidine cross-pathway regulation in Saccharomyces cerevisiae: a central role for a small molecule." Genetics. 170(1):61-70. PMID:15744050
  3. [ + ] Gavin AC, et al. (2002) "Functional organization of the yeast proteome by systematic analysis of protein complexes." Nature. 415(6868):141-147. PMID:11805826
  4. [ + ] Ho Y, et al. (2002) "Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry." Nature. 415(6868):180-183. PMID:11805837
  5. [ + ] Zekhnov AM, et al. (2000) "[The phenomenon of predetermination of the cytoplasm upon interaction between alleles of the ADE2 and ADE13 in the yeast Saccharomyces cerevisiae]" Genetika. 36(4):470-481. PMID:10822807
  6. [ + ] Johnston M, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Nature. 387(6632 Suppl):87-90. PMID:9169871
  7. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  8. [ + ] Zekhnov AM, et al. (1995) "[Mutation of ade13-1 of the yeast Saccharomyces cerevisiae leads to the absence of growth on a complete medium with glucose and epistatically interacts with mutations in other genes for purine biosynthesis]" Genetika. 31(1):15-23. PMID:7896125
  9. [ + ] Dorfman BZ, et al. (1969) "The isolation of adenylosuccinate synthetase mutants in yeast by selection for constitutive behavior in pigmented strains." Genetics. 61(2):377-389. PMID:5807803