ACO1 | GeneID:851013 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 851013 Official Symbol ACO1
Locus YLR304C Gene Type protein-coding
Synonyms GLU1
Full Name N/A
Description Aco1p
Chromosome N/A
Also Known As Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 856

ID Symbol Protein Species
GeneID:50 ACO2 NP_001089.1 Homo sapiens
GeneID:11429 Aco2 NP_542364.1 Mus musculus
GeneID:44149 Acon NP_524708.1 Drosophila melanogaster
GeneID:79250 Aco2 NP_077374.2 Rattus norvegicus
GeneID:176121 aco-2 NP_741235.1 Caenorhabditis elegans
GeneID:280976 ACO2 NP_776402.1 Bos taurus
GeneID:322670 aco2 NP_944590.1 Danio rerio
GeneID:374009 ACO2 NP_989519.1 Gallus gallus
GeneID:470193 ACO2 XP_001141262.1 Pan troglodytes
GeneID:474487 ACO2 XP_858303.1 Canis lupus familiaris
GeneID:851013 ACO1 NP_013407.1 Saccharomyces cerevisiae
GeneID:1278105 AgaP_AGAP007852 XP_317642.2 Anopheles gambiae
GeneID:2541450 SPAC24C9.06c NP_594031.1 Schizosaccharomyces pombe
GeneID:2676822 MGG_03521 XP_360978.1 Magnaporthe grisea
GeneID:2713053 NCU02366.1 XP_331142.1 Neurospora crassa
GeneID:2891900 KLLA0C17314g XP_452974.1 Kluyveromyces lactis
GeneID:4620213 AGOS_ADL032W NP_984065.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0005829 Component cytosol
GO:0005759 Component mitochondrial matrix
GO:0042645 Component mitochondrial nucleoid
GO:0005739 Component mitochondrion
GO:0051539 Function 4 iron, 4 sulfur cluster binding
GO:0003994 Function aconitate hydratase activity
GO:0003690 Function double-stranded DNA binding
GO:0005506 Function iron ion binding
GO:0051536 Function iron-sulfur cluster binding
GO:0016829 Function lyase activity
GO:0046872 Function metal ion binding
GO:0003697 Function single-stranded DNA binding
GO:0006101 Process citrate metabolic process
GO:0006537 Process glutamate biosynthetic process
GO:0008152 Process metabolic process
GO:0000002 Process mitochondrial genome maintenance
GO:0055114 Process oxidation reduction
GO:0006793 Process phosphorus metabolic process
GO:0019541 Process propionate metabolic process
GO:0042493 Process response to drug
GO:0006099 Process tricarboxylic acid cycle
GO:0007039 Process vacuolar protein catabolic process

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

AAB67348   NP_013407   P19414   S50387  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ABF2 ABF2 / ACO1 Affinity Capture-Western Kucej M (2008)
ABF2 ABF2 / ACO1 Dosage Rescue Chen XJ (2005)
APE2 APE2 / ACO1 Affinity Capture-MS Gavin AC (2006)
CIT1 ACO1 / CIT1 Phenotypic Enhancement Lin AP (2008)
CIT1 ACO1 / CIT1 Phenotypic Suppression Lin AP (2008)
CIT1 ACO1 / CIT1 Synthetic Rescue Lin AP (2008)
CMD1 ACO1 / CMD1 Affinity Capture-MS Krogan NJ (2006)
DIG2 DIG2 / ACO1 Affinity Capture-MS Ho Y (2002)
DNL4 DNL4 / ACO1 Affinity Capture-MS Ho Y (2002)
ERB1 ERB1 / ACO1 Affinity Capture-MS Ho Y (2002)
FAA4 FAA4 / ACO1 Affinity Capture-MS Gavin AC (2006)
HRR25 HRR25 / ACO1 Affinity Capture-MS Ho Y (2002)
HSC82 HSC82 / ACO1 Synthetic Growth Defect McClellan AJ (2007)
HSP42 ACO1 / HSP42 Affinity Capture-MS Krogan NJ (2006)
HSP82 HSP82 / ACO1 Synthetic Growth Defect McClellan AJ (2007)
KSS1 KSS1 / ACO1 Affinity Capture-MS Ho Y (2002)
MEC1 MEC1 / ACO1 Affinity Capture-MS Ho Y (2002)
MLC1 ACO1 / MLC1 Affinity Capture-MS Krogan NJ (2006)
MYO4 ACO1 / MYO4 Affinity Capture-MS Krogan NJ (2006)
NAS2 NAS2 / ACO1 Affinity Capture-MS Ho Y (2002)
NPT1 NPT1 / ACO1 Synthetic Growth Defect Pan X (2006)
RAD26 RAD26 / ACO1 Affinity Capture-MS Ho Y (2002)
RAD3 RAD3 / ACO1 Affinity Capture-MS Ho Y (2002)
RFA1 RFA1 / ACO1 Affinity Capture-MS Ho Y (2002)
RFC4 RFC4 / ACO1 Affinity Capture-MS Ho Y (2002)
SAM1 SAM1 / ACO1 Affinity Capture-MS Gavin AC (2006)
SEN15 SEN15 / ACO1 Affinity Capture-MS Ho Y (2002)
TOP1 TOP1 / ACO1 Affinity Capture-MS Ho Y (2002)
UFD4 UFD4 / ACO1 Affinity Capture-MS Krogan NJ (2006)
YHB1 YHB1 / ACO1 Affinity Capture-MS Gavin AC (2006)
YPT6 YPT6 / ACO1 Affinity Capture-MS Ho Y (2002)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Kucej M, et al. (2008) "Mitochondrial nucleoids undergo remodeling in response to metabolic cues." J Cell Sci. 121(Pt 11):1861-1868. PMID:18477605
  2. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  3. [ + ] McClellan AJ, et al. (2007) "Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches." Cell. 131(1):121-135. PMID:17923092
  4. [ + ] Chen XJ, et al. (2007) "Yeast aconitase binds and provides metabolically coupled protection to mitochondrial DNA." Proc Natl Acad Sci U S A. 104(34):13738-13743. PMID:17698960
  5. [ + ] Gavin AC, et al. (2006) "Proteome survey reveals modularity of the yeast cell machinery." Nature. 440(7084):631-636. PMID:16429126
  6. [ + ] Reinders J, et al. (2006) "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." J Proteome Res. 5(7):1543-1554. PMID:16823961
  7. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  8. [ + ] Pan X, et al. (2006) "A DNA integrity network in the yeast Saccharomyces cerevisiae." Cell. 124(5):1069-1081. PMID:16487579
  9. [ + ] Regev-Rudzki N, et al. (2005) "Yeast aconitase in two locations and two metabolic pathways: seeing small amounts is believing." Mol Biol Cell. 16(9):4163-4171. PMID:15975908
  10. [ + ] Puig S, et al. (2005) "Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation." Cell. 120(1):99-110. PMID:15652485
  11. [ + ] Chen XJ, et al. (2005) "Aconitase couples metabolic regulation to mitochondrial DNA maintenance." Science. 307(5710):714-717. PMID:15692048
  12. [ + ] Dilda PJ, et al. (2005) "Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains." J Natl Cancer Inst. 97(20):1539-1547. PMID:16234568
  13. [ + ] Bulteau AL, et al. (2004) "Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity." Science. 305(5681):242-245. PMID:15247478
  14. [ + ] Ho Y, et al. (2002) "Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry." Nature. 415(6868):180-183. PMID:11805837
  15. [ + ] Epstein CB, et al. (2001) "Genome-wide responses to mitochondrial dysfunction." Mol Biol Cell. 12(2):297-308. PMID:11179416
  16. [ + ] Kaufman BA, et al. (2000) "In organello formaldehyde crosslinking of proteins to mtDNA: identification of bifunctional proteins." Proc Natl Acad Sci U S A. 97(14):7772-7777. PMID:10869431
  17. [ + ] McAlister-Henn L, et al. (1997) "Molecular genetics of yeast TCA cycle isozymes." Prog Nucleic Acid Res Mol Biol. 57():317-339. PMID:9175438
  18. [ + ] Johnston M, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Nature. 387(6632 Suppl):87-90. PMID:9169871
  19. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441