ACS2 | GeneID:850846 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 850846 Official Symbol ACS2
Locus YLR153C Gene Type protein-coding
Synonyms
Full Name N/A
Description Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
Chromosome N/A
Also Known As Acs2p
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 101619

ID Symbol Protein Species
GeneID:423347 LOC423347 XP_001234991.1 Gallus gallus
GeneID:850846 ACS2 NP_013254.1 Saccharomyces cerevisiae
GeneID:2539546 SPCC191.02c NP_588291.2 Schizosaccharomyces pombe
GeneID:2676505 MGG_03201 XP_360658.2 Magnaporthe grisea
GeneID:2709028 NCU06836.1 XP_327122.1 Neurospora crassa
GeneID:2893299 ACS2_KLULA XP_453827.1 Kluyveromyces lactis
GeneID:3885698 PFF1350c XP_966261.1 Plasmodium falciparum
GeneID:4622812 AGOS_AGL148C NP_986519.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0005829 Component cytosol
GO:0005634 Component nucleus
GO:0003987 Function acetate-CoA ligase activity
GO:0016208 Function AMP binding
GO:0005524 Function ATP binding
GO:0003824 Function catalytic activity
GO:0016874 Function ligase activity
GO:0000166 Function nucleotide binding
GO:0006085 Process acetyl-CoA biosynthetic process
GO:0043284 Process biopolymer biosynthetic process
GO:0006066 Process cellular alcohol metabolic process
GO:0016573 Process histone acetylation
GO:0008152 Process metabolic process

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

AAB35143   AAB82387   CAA97725   NP_013254   P52910   S65002  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
AAT2 ACS2 / AAT2 Synthetic Lethality Lin YY (2008)
ADA2 ACS2 / ADA2 Synthetic Lethality Lin YY (2008)
ALG6 ACS2 / ALG6 Synthetic Growth Defect Lin YY (2008)
ALG6 ACS2 / ALG6 Synthetic Lethality Takahashi H (2006)
ANP1 ACS2 / ANP1 Synthetic Growth Defect Lin YY (2008)
ARP4 ACS2 / ARP4 Synthetic Lethality Lin YY (2008)
ARP6 ACS2 / ARP6 Synthetic Lethality Lin YY (2008)
BDF1 ACS2 / BDF1 Synthetic Lethality Lin YY (2008)
BRE1 ACS2 / BRE1 Synthetic Growth Defect Lin YY (2008)
BRE2 ACS2 / BRE2 Synthetic Growth Defect Lin YY (2008)
BRE5 ACS2 / BRE5 Synthetic Growth Defect Lin YY (2008)
BRE5 ACS2 / BRE5 Synthetic Lethality Takahashi H (2006)
CDC19 ACS2 / CDC19 Affinity Capture-MS Gavin AC (2006)
CLA4 ACS2 / CLA4 Synthetic Growth Defect Lin YY (2008)
CLA4 ACS2 / CLA4 Synthetic Lethality Takahashi H (2006)
COG6 ACS2 / COG6 Synthetic Growth Defect Lin YY (2008)
CTK3 ACS2 / CTK3 Synthetic Lethality Lin YY (2008)
DBP8 DBP8 / ACS2 Affinity Capture-MS Gavin AC (2006)
DFG16 ACS2 / DFG16 Synthetic Growth Defect Lin YY (2008)
DIA1 ACS2 / DIA1 Synthetic Growth Defect Lin YY (2008)
EAF3 ACS2 / EAF3 Synthetic Growth Defect Lin YY (2008)
EAF5 ACS2 / EAF5 Synthetic Growth Defect Lin YY (2008)
EAF6 ACS2 / EAF6 Synthetic Growth Defect Lin YY (2008)
EAF7 ACS2 / EAF7 Synthetic Growth Defect Lin YY (2008)
EFT1 ACS2 / EFT1 Affinity Capture-MS Gavin AC (2006)
ELP2 ACS2 / ELP2 Synthetic Growth Defect Lin YY (2008)
ELP3 ACS2 / ELP3 Synthetic Growth Defect Lin YY (2008)
ELP4 ACS2 / ELP4 Synthetic Growth Defect Lin YY (2008)
ELP6 ACS2 / ELP6 Synthetic Growth Defect Lin YY (2008)
EPL1 ACS2 / EPL1 Synthetic Lethality Lin YY (2008)
ESA1 ACS2 / ESA1 Synthetic Lethality Lin YY (2008)
GCN5 ACS2 / GCN5 Synthetic Lethality Lin YY (2008)
GCN5 ACS2 / GCN5 Synthetic Lethality Takahashi H (2006)
GPM1 ACS2 / GPM1 Affinity Capture-MS Gavin AC (2006)
HDA1 ACS2 / HDA1 Synthetic Rescue Lin YY (2008)
HDA2 ACS2 / HDA2 Synthetic Rescue Lin YY (2008)
HDA3 ACS2 / HDA3 Synthetic Rescue Lin YY (2008)
HFI1 ACS2 / HFI1 Synthetic Lethality Lin YY (2008)
HHT1 ACS2 / HHT1 Synthetic Lethality Lin YY (2008)
HOS1 ACS2 / HOS1 Synthetic Rescue Lin YY (2008)
HOS2 ACS2 / HOS2 Synthetic Rescue Lin YY (2008)
HOS3 ACS2 / HOS3 Synthetic Rescue Lin YY (2008)
HRD1 HRD1 / ACS2 Affinity Capture-MS Krogan NJ (2006)
HSP60 ACS2 / HSP60 Affinity Capture-MS Gavin AC (2006)
HST3 ACS2 / HST3 Synthetic Growth Defect Lin YY (2008)
HST4 ACS2 / HST4 Synthetic Growth Defect Lin YY (2008)
HTZ1 ACS2 / HTZ1 Synthetic Lethality Lin YY (2008)
IKI3 ACS2 / IKI3 Synthetic Growth Defect Lin YY (2008)
LGE1 ACS2 / LGE1 Synthetic Growth Defect Lin YY (2008)
LTE1 ACS2 / LTE1 Synthetic Growth Defect Lin YY (2008)
LTE1 ACS2 / LTE1 Synthetic Lethality Takahashi H (2006)
MDM20 ACS2 / MDM20 Synthetic Growth Defect Lin YY (2008)
MDM20 ACS2 / MDM20 Synthetic Lethality Takahashi H (2006)
MDN1 ACS2 / MDN1 Affinity Capture-MS Gavin AC (2006)
MNN10 ACS2 / MNN10 Synthetic Growth Defect Lin YY (2008)
MOG1 ACS2 / MOG1 Synthetic Growth Defect Lin YY (2008)
MON2 ACS2 / MON2 Synthetic Growth Defect Lin YY (2008)
MON2 ACS2 / MON2 Synthetic Lethality Takahashi H (2006)
N/A ACS2 / N/A Affinity Capture-MS Gavin AC (2006)
N/A ACS2 / N/A Synthetic Growth Defect Lin YY (2008)
NGG1 ACS2 / NGG1 Synthetic Lethality Lin YY (2008)
PEP5 ACS2 / PEP5 Synthetic Lethality Lin YY (2008)
PEP7 ACS2 / PEP7 Synthetic Lethality Lin YY (2008)
PHO23 ACS2 / PHO23 Synthetic Rescue Lin YY (2008)
PRP6 PRP6 / ACS2 Affinity Capture-MS Ho Y (2002)
PSA1 ACS2 / PSA1 Affinity Capture-MS Gavin AC (2006)
RAD6 ACS2 / RAD6 Synthetic Lethality Lin YY (2008)
RHO1 RHO1 / ACS2 Affinity Capture-MS Ho Y (2002)
RMD7 ACS2 / RMD7 Synthetic Growth Defect Lin YY (2008)
RMD7 ACS2 / RMD7 Synthetic Lethality Takahashi H (2006)
RNR1 ACS2 / RNR1 Affinity Capture-MS Gavin AC (2006)
RPD3 ACS2 / RPD3 Synthetic Rescue Lin YY (2008)
RPL10 RPL10 / ACS2 Two-hybrid Oender K (2003)
RPL20B ACS2 / RPL20B Synthetic Growth Defect Lin YY (2008)
RPN1 ACS2 / RPN1 Affinity Capture-MS Gavin AC (2006)
RPS0A ACS2 / RPS0A Affinity Capture-MS Gavin AC (2006)
RPS3 ACS2 / RPS3 Affinity Capture-MS Gavin AC (2006)
RUD3 ACS2 / RUD3 Synthetic Growth Defect Lin YY (2008)
RUD3 ACS2 / RUD3 Synthetic Lethality Takahashi H (2006)
SAM1 ACS2 / SAM1 Affinity Capture-MS Gavin AC (2006)
SAM2 ACS2 / SAM2 Affinity Capture-MS Gavin AC (2006)
SAP30 ACS2 / SAP30 Synthetic Rescue Lin YY (2008)
SAS2 ACS2 / SAS2 Synthetic Growth Defect Lin YY (2008)
SAS2 ACS2 / SAS2 Synthetic Lethality Takahashi H (2006)
SAS3 ACS2 / SAS3 Synthetic Growth Defect Lin YY (2008)
SAS4 ACS2 / SAS4 Synthetic Growth Defect Lin YY (2008)
SAS5 ACS2 / SAS5 Synthetic Growth Defect Lin YY (2008)
SEC27 ACS2 / SEC27 Affinity Capture-MS Gavin AC (2006)
SEC28 ACS2 / SEC28 Synthetic Lethality Lin YY (2008)
SEC66 ACS2 / SEC66 Synthetic Growth Defect Lin YY (2008)
SEC72 ACS2 / SEC72 Synthetic Growth Defect Lin YY (2008)
SIN3 ACS2 / SIN3 Synthetic Rescue Lin YY (2008)
SIR2 ACS2 / SIR2 Synthetic Growth Defect Lin YY (2008)
SIR3 ACS2 / SIR3 Synthetic Growth Defect Lin YY (2008)
SIR4 ACS2 / SIR4 Synthetic Growth Defect Lin YY (2008)
SNF8 ACS2 / SNF8 Synthetic Lethality Lin YY (2008)
SNP1 SNP1 / ACS2 Two-hybrid Fromont-Racine M (1997)
SPF1 ACS2 / SPF1 Synthetic Growth Defect Lin YY (2008)
SPF1 ACS2 / SPF1 Synthetic Lethality Takahashi H (2006)
SPT20 ACS2 / SPT20 Synthetic Lethality Lin YY (2008)
SPT3 ACS2 / SPT3 Synthetic Lethality Lin YY (2008)
SPT7 ACS2 / SPT7 Synthetic Lethality Lin YY (2008)
SPT8 ACS2 / SPT8 Synthetic Lethality Lin YY (2008)
SPT8 ACS2 / SPT8 Synthetic Lethality Takahashi H (2006)
SSE1 ACS2 / SSE1 Affinity Capture-MS Gavin AC (2006)
STC1 ACS2 / STC1 Synthetic Growth Defect Lin YY (2008)
STM1 ACS2 / STM1 Synthetic Lethality Lin YY (2008)
SUI1 SUI1 / ACS2 Affinity Capture-MS Ho Y (2002)
SWC3 ACS2 / SWC3 Synthetic Growth Defect Lin YY (2008)
SWC4 ACS2 / SWC4 Synthetic Lethality Lin YY (2008)
SWC5 ACS2 / SWC5 Synthetic Lethality Lin YY (2008)
SWD1 ACS2 / SWD1 Synthetic Growth Defect Lin YY (2008)
SWD3 ACS2 / SWD3 Synthetic Growth Defect Lin YY (2008)
SWM1 ACS2 / SWM1 Synthetic Growth Defect Lin YY (2008)
SWM1 ACS2 / SWM1 Synthetic Lethality Takahashi H (2006)
SWR1 ACS2 / SWR1 Synthetic Lethality Lin YY (2008)
TAF14 ACS2 / TAF14 Synthetic Growth Defect Lin YY (2008)
TEF1 ACS2 / TEF1 Affinity Capture-MS Gavin AC (2006)
TKL1 ACS2 / TKL1 Affinity Capture-MS Krogan NJ (2006)
TUB1 ACS2 / TUB1 Affinity Capture-MS Gavin AC (2006)
TUB3 ACS2 / TUB3 Affinity Capture-MS Gavin AC (2006)
UBP14 ACS2 / UBP14 Synthetic Growth Defect Lin YY (2008)
UBP14 ACS2 / UBP14 Synthetic Lethality Takahashi H (2006)
VAM3 ACS2 / VAM3 Synthetic Lethality Lin YY (2008)
VID21 ACS2 / VID21 Synthetic Lethality Lin YY (2008)
VMA5 ACS2 / VMA5 Synthetic Lethality Lin YY (2008)
VMA6 ACS2 / VMA6 Synthetic Lethality Lin YY (2008)
VPH1 ACS2 / VPH1 Synthetic Growth Defect Lin YY (2008)
VPH1 ACS2 / VPH1 Synthetic Lethality Takahashi H (2006)
VPS15 ACS2 / VPS15 Synthetic Lethality Lin YY (2008)
VPS3 ACS2 / VPS3 Synthetic Lethality Lin YY (2008)
VPS41 ACS2 / VPS41 Synthetic Lethality Lin YY (2008)
VPS45 ACS2 / VPS45 Synthetic Lethality Lin YY (2008)
VPS51 ACS2 / VPS51 Synthetic Lethality Lin YY (2008)
VPS71 ACS2 / VPS71 Synthetic Growth Defect Lin YY (2008)
VPS72 ACS2 / VPS72 Synthetic Growth Defect Lin YY (2008)
YAF9 ACS2 / YAF9 Synthetic Growth Defect Lin YY (2008)
YEF3 ACS2 / YEF3 Affinity Capture-MS Gavin AC (2006)
YNG1 ACS2 / YNG1 Synthetic Growth Defect Lin YY (2008)
YNG2 ACS2 / YNG2 Synthetic Lethality Lin YY (2008)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  2. [ + ] Takahashi H, et al. (2006) "Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription." Mol Cell. 23(2):207-217. PMID:16857587
  3. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  4. [ + ] Gavin AC, et al. (2006) "Proteome survey reveals modularity of the yeast cell machinery." Nature. 440(7084):631-636. PMID:16429126
  5. [ + ] Oender K, et al. (2003) "Translational regulator RpL10p/Grc5p interacts physically and functionally with Sed1p, a dynamic component of the yeast cell surface." Yeast. 20(4):281-294. PMID:12627396
  6. [ + ] Ho Y, et al. (2002) "Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry." Nature. 415(6868):180-183. PMID:11805837
  7. [ + ] de Jong-Gubbels P, et al. (1998) "Overproduction of acetyl-coenzyme A synthetase isoenzymes in respiring Saccharomyces cerevisiae cells does not reduce acetate production after exposure to glucose excess." FEMS Microbiol Lett. 165(1):15-20. PMID:9711835
  8. [ + ] Fromont-Racine M, et al. (1997) "Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens." Nat Genet. 16(3):277-282. PMID:9207794
  9. [ + ] Johnston M, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Nature. 387(6632 Suppl):87-90. PMID:9169871
  10. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  11. [ + ] van den Berg MA, et al. (1996) "The two acetyl-coenzyme A synthetases of Saccharomyces cerevisiae differ with respect to kinetic properties and transcriptional regulation." J Biol Chem. 271(46):28953-28959. PMID:8910545