ACF2 | GeneID:850836 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 850836 Official Symbol ACF2
Locus YLR144C Gene Type protein-coding
Synonyms ENG2; PCA1
Full Name N/A
Description Acf2p
Chromosome N/A
Also Known As Intracellular beta-1,3-endoglucanase, expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 56254

ID Symbol Protein Species
GeneID:831444 AT5G15870 NP_197091.1 Arabidopsis thaliana
GeneID:838411 AT1G18310 NP_173267.1 Arabidopsis thaliana
GeneID:850836 ACF2 NP_013245.1 Saccharomyces cerevisiae
GeneID:2541480 eng2 NP_594547.1 Schizosaccharomyces pombe
GeneID:2543379 eng1 NP_593162.1 Schizosaccharomyces pombe
GeneID:2674272 MGG_01001 XP_368243.2 Magnaporthe grisea
GeneID:2709276 NCU07076.1 XP_327362.1 Neurospora crassa
GeneID:2893251 KLLA0D17050g XP_453814.1 Kluyveromyces lactis
GeneID:4346925 Os09g0379900 NP_001063051.1 Oryza sativa
GeneID:4622799 AGOS_AGL161C NP_986506.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0005622 Component intracellular
GO:0033903 Function endo-1,3(4)-beta-glucanase activity
GO:0042973 Function glucan endo-1,3-beta-D-glucosidase activity
GO:0016787 Function hydrolase activity
GO:0016798 Function hydrolase activity, acting on glycosyl bonds
GO:0030036 Process actin cytoskeleton organization
GO:0016998 Process cell wall macromolecule catabolic process
GO:0008152 Process metabolic process

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

AAB82378   CAA97716   NP_013245   Q12168   S64993  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
CBF5 ACF2 / CBF5 Affinity Capture-MS Krogan NJ (2006)
CDC20 CDC20 / ACF2 Synthetic Growth Defect Lin YY (2008)
CRN1 ACF2 / CRN1 Affinity Capture-MS Krogan NJ (2006)
EHT1 EHT1 / ACF2 PCA Tarassov K (2008)
ERG11 ERG11 / ACF2 PCA Tarassov K (2008)
ERG27 ERG27 / ACF2 PCA Tarassov K (2008)
ERG7 ERG7 / ACF2 PCA Tarassov K (2008)
FAT1 FAT1 / ACF2 PCA Tarassov K (2008)
FIR1 ACF2 / FIR1 Affinity Capture-MS Krogan NJ (2006)
LSB1 ACF2 / LSB1 Affinity Capture-MS Krogan NJ (2006)
LSB3 LSB3 / ACF2 Protein-peptide Landgraf C (2004)
LSB3 LSB3 / ACF2 Two-hybrid Tong AH (2002)
MLC1 ACF2 / MLC1 Affinity Capture-MS Krogan NJ (2006)
PIL1 ACF2 / PIL1 Affinity Capture-MS Krogan NJ (2006)
RVS161 RVS161 / ACF2 Two-hybrid Germann M (2005)
RVS167 ACF2 / RVS167 Affinity Capture-MS Krogan NJ (2006)
RVS167 RVS167 / ACF2 Affinity Capture-Western Germann M (2005)
RVS167 RVS167 / ACF2 Protein-peptide Landgraf C (2004)
RVS167 RVS167 / ACF2 Two-hybrid Drees BL (2001)
RVS167 RVS167 / ACF2 Two-hybrid Germann M (2005)
RVS167 RVS167 / ACF2 Two-hybrid Tong AH (2002)
SEL1 ACF2 / SEL1 PCA Tarassov K (2008)
SLC1 SLC1 / ACF2 PCA Tarassov K (2008)
SNA3 SNA3 / ACF2 PCA Tarassov K (2008)
STC1 STC1 / ACF2 PCA Tarassov K (2008)
TDH1 ACF2 / TDH1 Affinity Capture-MS Krogan NJ (2006)
TDH2 ACF2 / TDH2 Affinity Capture-MS Krogan NJ (2006)
TGL1 TGL1 / ACF2 PCA Tarassov K (2008)
YSC84 YSC84 / ACF2 Protein-peptide Landgraf C (2004)
YSC84 YSC84 / ACF2 Two-hybrid Tong AH (2002)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Martin-Cuadrado AB, et al. (2008) "Characterization of the endo-beta-1,3-glucanase activity of S. cerevisiae Eng2 and other members of the GH81 family." Fungal Genet Biol. 45(4):542-553. PMID:17933563
  2. [ + ] Tarassov K, et al. (2008) "An in vivo map of the yeast protein interactome." Science. 320(5882):1465-1470. PMID:18467557
  3. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  4. [ + ] Germann M, et al. (2005) "Characterizing the sphingolipid signaling pathway that remediates defects associated with loss of the yeast amphiphysin-like orthologs, Rvs161p and Rvs167p." J Biol Chem. 280(6):4270-4278. PMID:15561700
  5. [ + ] Landgraf C, et al. (2004) "Protein interaction networks by proteome peptide scanning." PLoS Biol. 2(1):E14. PMID:14737190
  6. [ + ] Baladron V, et al. (2002) "Eng1p, an endo-1,3-beta-glucanase localized at the daughter side of the septum, is involved in cell separation in Saccharomyces cerevisiae." Eukaryot Cell. 1(5):774-786. PMID:12455695
  7. [ + ] Tong AH, et al. (2002) "A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules." Science. 295(5553):321-324. PMID:11743162
  8. [ + ] Drees BL, et al. (2001) "A protein interaction map for cell polarity development." J Cell Biol. 154(3):549-571. PMID:11489916
  9. [ + ] Lechler T, et al. (1997) "In vitro reconstitution of cortical actin assembly sites in budding yeast." J Cell Biol. 138(1):95-103. PMID:9214384
  10. [ + ] Johnston M, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Nature. 387(6632 Suppl):87-90. PMID:9169871
  11. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441