ACE2 | GeneID:850822 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 850822 Official Symbol ACE2
Locus YLR131C Gene Type protein-coding
Synonyms
Full Name N/A
Description Ace2p
Chromosome N/A
Also Known As Transcription factor that activates expression of early G1-specific genes, localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters, localization is regulated by phosphorylation; potential Cdc28p substrate
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 39698

ID Symbol Protein Species
GeneID:850822 ACE2 NP_013232.1 Saccharomyces cerevisiae
GeneID:851724 SWI5 NP_010430.1 Saccharomyces cerevisiae
GeneID:2892945 KLLA0D16456g XP_453786.1 Kluyveromyces lactis
GeneID:4622763 AGOS_AGL197W NP_986470.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005829 Component cytosol
GO:0005622 Component intracellular
GO:0005634 Component nucleus
GO:0003677 Function DNA binding
GO:0046872 Function metal ion binding
GO:0003676 Function nucleic acid binding
GO:0043565 Function sequence-specific DNA binding
GO:0016563 Function transcription activator activity
GO:0008270 Function zinc ion binding
GO:0006355 Process regulation of transcription, DNA-dependent
GO:0000114 Process regulation of transcription during G1 phase of mitotic cell cycle
GO:0006350 Process transcription

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
BUD4 BUD4 / ACE2 Synthetic Growth Defect Voth WP (2005)
CBK1 CBK1 / ACE2 Dosage Rescue Voth WP (2005)
CBK1 CBK1 / ACE2 Two-hybrid Racki WJ (2000)
CBK1 CBK1 / ACE2 Two-hybrid Sbia M (2008)
CDC28 CDC28 / ACE2 Biochemical Activity Ubersax JA (2003)
CLB2 ACE2 / CLB2 Affinity Capture-Western Archambault V (2004)
CLB2 CLB2 / ACE2 Biochemical Activity Ubersax JA (2003)
CLB3 CLB3 / ACE2 Affinity Capture-MS Archambault V (2004)
CLB3 ACE2 / CLB3 Affinity Capture-Western Archambault V (2004)
CLN2 ACE2 / CLN2 Affinity Capture-Western Archambault V (2004)
CRM1 ACE2 / CRM1 Reconstituted Complex Jensen TH (2000)
CRM1 ACE2 / CRM1 Two-hybrid Bourens M (2008)
CRM1 CRM1 / ACE2 Two-hybrid Bourens M (2008)
CRM1 CRM1 / ACE2 Two-hybrid Jensen TH (2000)
CUP2 CUP2 / ACE2 Dosage Rescue Butler G (1991)
FKH1 ACE2 / FKH1 Phenotypic Suppression Voth WP (2007)
FKH2 ACE2 / FKH2 Phenotypic Suppression Voth WP (2007)
FLO8 FLO8 / ACE2 Dosage Rescue King L (1998)
FPR1 FPR1 / ACE2 Affinity Capture-MS Krogan NJ (2006)
GSP2 ACE2 / GSP2 Two-hybrid Jensen TH (2000)
HDA2 ACE2 / HDA2 Two-hybrid Newman JR (2000)
HXK1 ACE2 / HXK1 Affinity Capture-MS Krogan NJ (2006)
HYM1 HYM1 / ACE2 Dosage Rescue Voth WP (2005)
KIC1 KIC1 / ACE2 Dosage Rescue Voth WP (2005)
KRE6 KRE6 / ACE2 Synthetic Lethality Tong AH (2004)
KSP1 KSP1 / ACE2 Biochemical Activity Ptacek J (2005)
MCK1 MCK1 / ACE2 Biochemical Activity Ptacek J (2005)
MOB2 MOB2 / ACE2 Dosage Rescue Voth WP (2005)
MOB2 MOB2 / ACE2 Two-hybrid Colman-Lerner A (2001)
N/A ACE2 / N/A Affinity Capture-MS Krogan NJ (2006)
N/A N/A / ACE2 Two-hybrid Uetz P (2000)
NCE103 ACE2 / NCE103 Synthetic Rescue Dohrmann PR (1996)
NUP42 ACE2 / NUP42 Two-hybrid Jensen TH (2000)
PSE1 ACE2 / PSE1 Affinity Capture-MS Krogan NJ (2006)
RPD3 ACE2 / RPD3 Phenotypic Suppression Voth WP (2007)
RRP1 ACE2 / RRP1 Affinity Capture-MS Krogan NJ (2006)
SDS3 ACE2 / SDS3 Phenotypic Suppression Voth WP (2007)
SIN3 ACE2 / SIN3 Phenotypic Suppression Voth WP (2007)
SUA7 SUA7 / ACE2 Reconstituted Complex Zhang DY (2000)
SWI5 SWI5 / ACE2 Phenotypic Enhancement Voth WP (2005)
SWI5 ACE2 / SWI5 Phenotypic Enhancement Voth WP (2007)
UBP15 UBP15 / ACE2 Affinity Capture-MS Gavin AC (2002)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Mazanka E, et al. (2008) "The NDR/LATS family kinase Cbk1 directly controls transcriptional asymmetry." PLoS Biol. 6(8):e203. PMID:18715118
  2. [ + ] Sbia M, et al. (2008) "Regulation of the yeast Ace2 transcription factor during the cell cycle." J Biol Chem. 283(17):11135-11145. PMID:18292088
  3. [ + ] Bourens M, et al. (2008) "Mutations in a small region of the exportin Crm1p disrupt the daughter cell-specific nuclear localization of the transcription factor Ace2p in Saccharomyces cerevisiae." Biol Cell. 100(6):343-354. PMID:18076379
  4. [ + ] Voth WP, et al. (2007) "Forkhead proteins control the outcome of transcription factor binding by antiactivation." EMBO J. 26(20):4324-4334. PMID:17898805
  5. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  6. [ + ] Jansen JM, et al. (2006) "Phosphoregulation of Cbk1 is critical for RAM network control of transcription and morphogenesis." J Cell Biol. 175(5):755-766. PMID:17145962
  7. [ + ] Ptacek J, et al. (2005) "Global analysis of protein phosphorylation in yeast." Nature. 438(7068):679-684. PMID:16319894
  8. [ + ] Voth WP, et al. (2005) "ACE2, CBK1, and BUD4 in budding and cell separation." Eukaryot Cell. 4(6):1018-1028. PMID:15947194
  9. [ + ] Archambault V, et al. (2004) "Targeted proteomic study of the cyclin-Cdk module." Mol Cell. 14(6):699-711. PMID:15200949
  10. [ + ] Tong AH, et al. (2004) "Global mapping of the yeast genetic interaction network." Science. 303(5659):808-813. PMID:14764870
  11. [ + ] Ubersax JA, et al. (2003) "Targets of the cyclin-dependent kinase Cdk1." Nature. 425(6960):859-864. PMID:14574415
  12. [ + ] Gavin AC, et al. (2002) "Functional organization of the yeast proteome by systematic analysis of protein complexes." Nature. 415(6868):141-147. PMID:11805826
  13. [ + ] Colman-Lerner A, et al. (2001) "Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates." Cell. 107(6):739-750. PMID:11747810
  14. [ + ] Newman JR, et al. (2000) "A computationally directed screen identifying interacting coiled coils from Saccharomyces cerevisiae." Proc Natl Acad Sci U S A. 97(24):13203-13208. PMID:11087867
  15. [ + ] Jensen TH, et al. (2000) "Identification of novel Saccharomyces cerevisiae proteins with nuclear export activity: cell cycle-regulated transcription factor ace2p shows cell cycle-independent nucleocytoplasmic shuttling." Mol Cell Biol. 20(21):8047-8058. PMID:11027275
  16. [ + ] Racki WJ, et al. (2000) "Cbk1p, a protein similar to the human myotonic dystrophy kinase, is essential for normal morphogenesis in Saccharomyces cerevisiae." EMBO J. 19(17):4524-4532. PMID:10970846
  17. [ + ] Zhang DY, et al. (2000) "Intramolecular interaction of yeast TFIIB in transcription control." Nucleic Acids Res. 28(9):1913-1920. PMID:10756191
  18. [ + ] Uetz P, et al. (2000) "A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae." Nature. 403(6770):623-627. PMID:10688190
  19. [ + ] McBride HJ, et al. (1999) "Distinct regions of the Swi5 and Ace2 transcription factors are required for specific gene activation." J Biol Chem. 274(30):21029-21036. PMID:10409653
  20. [ + ] King L, et al. (1998) "Ace2p, a regulator of CTS1 (chitinase) expression, affects pseudohyphal production in Saccharomyces cerevisiae." Curr Genet. 34(3):183-191. PMID:9745020
  21. [ + ] Johnston M, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Nature. 387(6632 Suppl):87-90. PMID:9169871
  22. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  23. [ + ] Dohrmann PR, et al. (1996) "Role of negative regulation in promoter specificity of the homologous transcriptional activators Ace2p and Swi5p." Mol Cell Biol. 16(4):1746-1758. PMID:8657150
  24. [ + ] Dohrmann PR, et al. (1992) "Parallel pathways of gene regulation: homologous regulators SWI5 and ACE2 differentially control transcription of HO and chitinase." Genes Dev. 6(1):93-104. PMID:1730413
  25. [ + ] Butler G, et al. (1991) "ACE2, an activator of yeast metallothionein expression which is homologous to SWI5." Mol Cell Biol. 11(1):476-485. PMID:1986241