ADE16 | GeneID:850715 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 850715 Official Symbol ADE16
Locus YLR028C Gene Type protein-coding
Synonyms
Full Name N/A
Description Ade16p
Chromosome N/A
Also Known As Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidine
Summary N/A

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005829 Component cytosol
GO:0003824 Function catalytic activity
GO:0016787 Function hydrolase activity
GO:0003937 Function IMP cyclohydrolase activity
GO:0004643 Function phosphoribosylaminoimidazolecarboxamide formyltransferase activity
GO:0016740 Function transferase activity
GO:0009060 Process aerobic respiration
GO:0030437 Process ascospore formation
GO:0006189 Process 'de novo' IMP biosynthetic process
GO:0006188 Process IMP biosynthetic process
GO:0006164 Process purine nucleotide biosynthetic process

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

AAB57774   CAA97552   NP_013128   P54113   S77707  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ADE16 ADE16 / ADE16 PCA Tarassov K (2008)
ADE17 ADE16 / ADE17 Affinity Capture-MS Collins SR (2007)
ADE17 ADE16 / ADE17 Affinity Capture-MS Krogan NJ (2006)
ADE17 ADE16 / ADE17 PCA Tarassov K (2008)
ADE17 ADE16 / ADE17 Phenotypic Enhancement Tibbetts AS (2000)
ADE4 ADE16 / ADE4 Dosage Lethality Rebora K (2005)
BMH1 BMH1 / ADE16 Affinity Capture-MS Collins SR (2007)
BMH1 ADE16 / BMH1 Affinity Capture-MS Gavin AC (2006)
GLC7 GLC7 / ADE16 Affinity Capture-MS Collins SR (2007)
GLC7 ADE16 / GLC7 Affinity Capture-MS Gavin AC (2006)
GLC7 GLC7 / ADE16 Affinity Capture-MS Gavin AC (2006)
GLC7 GLC7 / ADE16 Affinity Capture-MS Graumann J (2004)
GLC7 GLC7 / ADE16 Affinity Capture-MS Krogan NJ (2006)
LSP1 ADE16 / LSP1 PCA Tarassov K (2008)
PHO4 PHO4 / ADE16 Affinity Capture-MS Graumann J (2004)
PMU1 ADE16 / PMU1 Dosage Rescue Rebora K (2005)
PSK1 PSK1 / ADE16 Dosage Rescue Rutter J (2002)
PSK2 PSK2 / ADE16 Dosage Rescue Rutter J (2002)
REG1 REG1 / ADE16 PCA Tarassov K (2008)
SLX1 ADE16 / SLX1 Affinity Capture-MS Krogan NJ (2006)
SOL1 SOL1 / ADE16 Affinity Capture-MS Krogan NJ (2006)
SOL2 SOL2 / ADE16 Affinity Capture-MS Collins SR (2007)
SOL2 ADE16 / SOL2 Affinity Capture-MS Gavin AC (2006)
SSL2 SSL2 / ADE16 PCA Tarassov K (2008)
VMA8 VMA8 / ADE16 PCA Tarassov K (2008)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Tarassov K, et al. (2008) "An in vivo map of the yeast protein interactome." Science. 320(5882):1465-1470. PMID:18467557
  2. [ + ] Collins SR, et al. (2007) "Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae." Mol Cell Proteomics. 6(3):439-450. PMID:17200106
  3. [ + ] Gavin AC, et al. (2006) "Proteome survey reveals modularity of the yeast cell machinery." Nature. 440(7084):631-636. PMID:16429126
  4. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  5. [ + ] Rebora K, et al. (2005) "Revisiting purine-histidine cross-pathway regulation in Saccharomyces cerevisiae: a central role for a small molecule." Genetics. 170(1):61-70. PMID:15744050
  6. [ + ] Graumann J, et al. (2004) "Applicability of tandem affinity purification MudPIT to pathway proteomics in yeast." Mol Cell Proteomics. 3(3):226-237. PMID:14660704
  7. [ + ] Rutter J, et al. (2002) "Coordinate regulation of sugar flux and translation by PAS kinase." Cell. 111(1):17-28. PMID:12372297
  8. [ + ] Tibbetts AS, et al. (2000) "Characterization of two 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase isozymes from Saccharomyces cerevisiae." J Biol Chem. 275(27):20920-20927. PMID:10877846
  9. [ + ] Johnston M, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Nature. 387(6632 Suppl):87-90. PMID:9169871
  10. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441