AAT2 | GeneID:850714 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 850714 Official Symbol AAT2
Locus YLR027C Gene Type protein-coding
Synonyms ASP5
Full Name N/A
Description Aat2p
Chromosome N/A
Also Known As Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 1571

ID Symbol Protein Species
GeneID:2805 GOT1 NP_002070.1 Homo sapiens
GeneID:14718 Got1 NP_034454.1 Mus musculus
GeneID:24401 Got1 NP_036703.1 Rattus norvegicus
GeneID:36782 Got1 NP_725534.1 Drosophila melanogaster
GeneID:181726 aminotransferase NP_510709.1 Caenorhabditis elegans
GeneID:281206 GOT1 NP_803468.1 Bos taurus
GeneID:396261 GOT1 NP_990652.1 Gallus gallus
GeneID:406330 got1 NP_998222.1 Danio rerio
GeneID:450664 GOT1 XP_001166759.1 Pan troglodytes
GeneID:486834 GOT1 XP_543963.1 Canis lupus familiaris
GeneID:831024 ASP3 NP_196713.1 Arabidopsis thaliana
GeneID:850714 AAT2 NP_013127.2 Saccharomyces cerevisiae
GeneID:1273967 AgaP_AGAP004142 XP_313023.2 Anopheles gambiae
GeneID:2543020 SPAC10F6.13c NP_593264.1 Schizosaccharomyces pombe
GeneID:2677635 MGG_04156 XP_361682.1 Magnaporthe grisea
GeneID:2710537 NCU07941.1 XP_328647.1 Neurospora crassa
GeneID:2895619 KLLA0F17754g XP_455876.1 Kluyveromyces lactis
GeneID:4325621 Os01g0760600 NP_001044317.1 Oryza sativa
GeneID:4622019 AGOS_AFR211C NP_985758.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0005829 Component cytosol
GO:0005777 Component peroxisome
GO:0003824 Function catalytic activity
GO:0004069 Function L-aspartate:2-oxoglutarate aminotransferase activity
GO:0030170 Function pyridoxal phosphate binding
GO:0008483 Function transaminase activity
GO:0016740 Function transferase activity
GO:0016769 Function transferase activity, transferring nitrogenous groups
GO:0006532 Process aspartate biosynthetic process
GO:0009058 Process biosynthetic process
GO:0006520 Process cellular amino acid metabolic process
GO:0006082 Process organic acid metabolic process

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

NP_013127   P23542  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
AAT2 AAT2 / AAT2 Reconstituted Complex Jeffery CJ (1998)
ACS2 ACS2 / AAT2 Synthetic Lethality Lin YY (2008)
CDC11 CDC11 / AAT2 PCA Tarassov K (2008)
CDC3 CDC3 / AAT2 Affinity Capture-MS Ho Y (2002)
CTF18 CTF18 / AAT2 Synthetic Growth Defect Pan X (2006)
CTF4 CTF4 / AAT2 Synthetic Lethality Pan X (2006)
CTF8 CTF8 / AAT2 Synthetic Growth Defect Pan X (2006)
DCC1 DCC1 / AAT2 Synthetic Growth Defect Pan X (2006)
EAF3 EAF3 / AAT2 Synthetic Growth Defect Lin YY (2008)
EAF6 EAF6 / AAT2 Synthetic Growth Defect Lin YY (2008)
EFT2 AAT2 / EFT2 Affinity Capture-MS Krogan NJ (2006)
ELP3 ELP3 / AAT2 Synthetic Growth Defect Lin YY (2008)
FUN30 AAT2 / FUN30 Affinity Capture-MS Krogan NJ (2006)
GDH2 GDH2 / AAT2 PCA Tarassov K (2008)
HDA3 HDA3 / AAT2 Synthetic Lethality Lin YY (2008)
HOS3 HOS3 / AAT2 Synthetic Growth Defect Lin YY (2008)
INO1 INO1 / AAT2 PCA Tarassov K (2008)
LSP1 AAT2 / LSP1 PCA Tarassov K (2008)
LTE1 LTE1 / AAT2 Synthetic Lethality Ye P (2005)
NPL6 NPL6 / AAT2 Synthetic Growth Defect Wilson B (2006)
PCL2 PCL2 / AAT2 Biochemical Activity Ptacek J (2005)
PCL9 PCL9 / AAT2 Biochemical Activity Ptacek J (2005)
PEX11 AAT2 / PEX11 PCA Tarassov K (2008)
PHO23 PHO23 / AAT2 Synthetic Growth Defect Lin YY (2008)
PHO80 PHO80 / AAT2 Biochemical Activity Ptacek J (2005)
RAD27 RAD27 / AAT2 Synthetic Lethality Loeillet S (2005)
RMD7 RMD7 / AAT2 Synthetic Growth Defect Pan X (2006)
RSP5 RSP5 / AAT2 Reconstituted Complex Gupta R (2007)
RTG2 AAT2 / RTG2 Synthetic Rescue Velot C (1996)
SEN15 SEN15 / AAT2 Affinity Capture-MS Ho Y (2002)
SPT8 SPT8 / AAT2 Synthetic Lethality Lin YY (2008)
SUI1 SUI1 / AAT2 Affinity Capture-MS Ho Y (2002)
TDH2 AAT2 / TDH2 Affinity Capture-MS Krogan NJ (2006)
TOR1 TOR1 / AAT2 Phenotypic Suppression Chan TF (2000)
URA7 URA7 / AAT2 PCA Tarassov K (2008)
YAF9 YAF9 / AAT2 Synthetic Lethality Lin YY (2008)
YNG2 YNG2 / AAT2 Synthetic Lethality Lin YY (2008)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Huttenhower C, et al. (2008) "Assessing the functional structure of genomic data." Bioinformatics. 24(13):i330-i338. PMID:18586732
  2. [ + ] Tarassov K, et al. (2008) "An in vivo map of the yeast protein interactome." Science. 320(5882):1465-1470. PMID:18467557
  3. [ + ] Gupta R, et al. (2007) "Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast." Mol Syst Biol. 3():116. PMID:17551511
  4. [ + ] Wilson B, et al. (2006) "The RSC chromatin remodeling complex bears an essential fungal-specific protein module with broad functional roles." Genetics. 172(2):795-809. PMID:16204215
  5. [ + ] Krogan NJ, et al. (2006) "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae." Nature. 440(7084):637-643. PMID:16554755
  6. [ + ] Pan X, et al. (2006) "A DNA integrity network in the yeast Saccharomyces cerevisiae." Cell. 124(5):1069-1081. PMID:16487579
  7. [ + ] Loeillet S, et al. (2005) "Genetic network interactions among replication, repair and nuclear pore deficiencies in yeast." DNA Repair (Amst). 4(4):459-468. PMID:15725626
  8. [ + ] Ptacek J, et al. (2005) "Global analysis of protein phosphorylation in yeast." Nature. 438(7068):679-684. PMID:16319894
  9. [ + ] Ye P, et al. (2005) "Gene function prediction from congruent synthetic lethal interactions in yeast." Mol Syst Biol. 1():2005.0026. PMID:16729061
  10. [ + ] Ho Y, et al. (2002) "Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry." Nature. 415(6868):180-183. PMID:11805837
  11. [ + ] Chan TF, et al. (2000) "A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR)." Proc Natl Acad Sci U S A. 97(24):13227-13232. PMID:11078525
  12. [ + ] Jeffery CJ, et al. (1998) "Crystal structure of Saccharomyces cerevisiae cytosolic aspartate aminotransferase." Protein Sci. 7(6):1380-1387. PMID:9655342
  13. [ + ] Johnston M, et al. (1997) "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Nature. 387(6632 Suppl):87-90. PMID:9169871
  14. [ + ] Verleur N, et al. (1997) "Cytosolic aspartate aminotransferase encoded by the AAT2 gene is targeted to the peroxisomes in oleate-grown Saccharomyces cerevisiae." Eur J Biochem. 247(3):972-980. PMID:9288922
  15. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  16. [ + ] Velot C, et al. (1996) "The Saccharomyces cerevisiae RTG2 gene is a regulator of aconitase expression under catabolite repression conditions." Genetics. 144(3):893-903. PMID:8913736
  17. [ + ] Cronin VB, et al. (1991) "The amino acid sequence of the aspartate aminotransferase from baker's yeast (Saccharomyces cerevisiae)." Biochem J. 277 ( Pt 2)():335-340. PMID:1859361