ABP1 | GeneID:850450 | Saccharomyces cerevisiae

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 850450 Official Symbol ABP1
Locus YCR088W Gene Type protein-coding
Synonyms
Full Name N/A
Description Abp1p
Chromosome N/A
Also Known As Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 84743

ID Symbol Protein Species
GeneID:850450 ABP1 NP_010012.1 Saccharomyces cerevisiae
GeneID:2895883 KLLA0F10175g XP_455543.1 Kluyveromyces lactis

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0030479 Component actin cortical patch
GO:0015629 Component actin cytoskeleton
GO:0005938 Component cell cortex
GO:0044448 Component cell cortex part
GO:0030864 Component cortical actin cytoskeleton
GO:0030863 Component cortical cytoskeleton
GO:0005737 Component cytoplasm
GO:0044430 Component cytoskeletal part
GO:0005856 Component cytoskeleton
GO:0005622 Component intracellular
GO:0043332 Component mating projection tip
GO:0003779 Function actin binding
GO:0008092 Function cytoskeletal protein binding
GO:0005515 Function protein binding
GO:0000147 Process actin cortical patch assembly
GO:0030010 Process establishment of cell polarity

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

CAA42253   LLBY   NP_010012   P15891  

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ACT1 ABP1 / ACT1 Affinity Capture-MS Collins SR (2007)
ACT1 ACT1 / ABP1 Co-fractionation Goode BL (2001)
ACT1 ABP1 / ACT1 Co-localization Drubin DG (1988)
ACT1 ACT1 / ABP1 Synthetic Haploinsufficiency Haarer B (2007)
APP1 APP1 / ABP1 Affinity Capture-MS Ho Y (2002)
APP1 APP1 / ABP1 Affinity Capture-Western Landgraf C (2004)
APP1 ABP1 / APP1 Protein-peptide Fazi B (2002)
APP1 ABP1 / APP1 Protein-peptide Landgraf C (2004)
APP1 ABP1 / APP1 Two-hybrid Drees BL (2001)
APP1 ABP1 / APP1 Two-hybrid Tong AH (2002)
ARK1 ABP1 / ARK1 Affinity Capture-Western Fazi B (2002)
ARK1 ABP1 / ARK1 Protein-peptide Landgraf C (2004)
ARK1 ABP1 / ARK1 Two-hybrid Tong AH (2002)
ARP2 ARP2 / ABP1 Affinity Capture-Western Goode BL (2001)
ARP2 ABP1 / ARP2 Synthetic Growth Defect D'Agostino JL (2005)
ARP2 ARP2 / ABP1 Synthetic Rescue D'Agostino JL (2005)
ARP3 ABP1 / ARP3 Affinity Capture-MS Ho Y (2002)
ARP3 ARP3 / ABP1 Co-fractionation Goode BL (2001)
CHC1 CHC1 / ABP1 Co-localization Newpher TM (2005)
CLA4 ABP1 / CLA4 Two-hybrid Drees BL (2001)
CRN1 ABP1 / CRN1 Affinity Capture-MS Collins SR (2007)
FMP34 FMP34 / ABP1 Affinity Capture-MS Ho Y (2002)
HRR25 HRR25 / ABP1 Affinity Capture-MS Ho Y (2002)
HUA2 ABP1 / HUA2 Two-hybrid Drees BL (2001)
HUA2 ABP1 / HUA2 Two-hybrid Tong AH (2002)
HXT7 ABP1 / HXT7 Affinity Capture-MS Ho Y (2002)
INP51 INP51 / ABP1 Phenotypic Enhancement Stefan CJ (2005)
INP52 ABP1 / INP52 Affinity Capture-Western Stefan CJ (2005)
INP52 INP52 / ABP1 Co-localization Stefan CJ (2005)
INP52 ABP1 / INP52 Protein-peptide Fazi B (2002)
INP52 ABP1 / INP52 Two-hybrid Tong AH (2002)
LAS17 LAS17 / ABP1 Synthetic Rescue D'Agostino JL (2005)
LSP1 ABP1 / LSP1 Affinity Capture-MS Collins SR (2007)
N/A N/A / ABP1 Affinity Capture-Western Landgraf C (2004)
N/A ABP1 / N/A Protein-peptide Landgraf C (2004)
PRK1 PRK1 / ABP1 Affinity Capture-MS Ho Y (2002)
PRK1 ABP1 / PRK1 Affinity Capture-Western Fazi B (2002)
PRK1 PRK1 / ABP1 Affinity Capture-Western Landgraf C (2004)
PRK1 PRK1 / ABP1 Phenotypic Enhancement Cope MJ (1999)
PRK1 ABP1 / PRK1 Protein-peptide Landgraf C (2004)
PRK1 ABP1 / PRK1 Synthetic Lethality Haynes J (2007)
PRK1 ABP1 / PRK1 Two-hybrid Tong AH (2002)
RVS161 RVS161 / ABP1 Affinity Capture-MS Collins SR (2007)
RVS161 RVS161 / ABP1 Synthetic Growth Defect Germann M (2005)
RVS167 RVS167 / ABP1 Two-hybrid Colwill K (1999)
RVS167 RVS167 / ABP1 Two-hybrid Drees BL (2001)
SAC6 ABP1 / SAC6 Affinity Capture-MS Collins SR (2007)
SAC6 ABP1 / SAC6 Co-localization Huckaba TM (2004)
SAC6 SAC6 / ABP1 Synthetic Growth Defect Goode BL (2001)
SAC6 ABP1 / SAC6 Synthetic Lethality Adams AE (1993)
SAC6 ABP1 / SAC6 Synthetic Lethality Haynes J (2007)
SAC6 SAC6 / ABP1 Synthetic Lethality Holtzman DA (1993)
SAC6 SAC6 / ABP1 Synthetic Lethality Holtzman DA (1994)
SCD5 SCD5 / ABP1 Synthetic Growth Defect Henry KR (2002)
SCP1 ABP1 / SCP1 Affinity Capture-MS Ho Y (2002)
SCP1 SCP1 / ABP1 Affinity Capture-Western Landgraf C (2004)
SCP1 ABP1 / SCP1 Protein-peptide Landgraf C (2004)
SLA1 ABP1 / SLA1 Affinity Capture-Western Warren DT (2002)
SLA1 SLA1 / ABP1 Affinity Capture-Western Warren DT (2002)
SLA1 SLA1 / ABP1 FRET Warren DT (2002)
SLA1 SLA1 / ABP1 Synthetic Lethality Haynes J (2007)
SLA1 SLA1 / ABP1 Synthetic Lethality Holtzman DA (1993)
SLA2 SLA2 / ABP1 Synthetic Lethality Holtzman DA (1993)
SLA2 SLA2 / ABP1 Synthetic Lethality Wesp A (1997)
SPS1 ABP1 / SPS1 Affinity Capture-MS Ho Y (2002)
SRV2 ABP1 / SRV2 Affinity Capture-Western Warren DT (2002)
SRV2 SRV2 / ABP1 Co-fractionation Balcer HI (2003)
SRV2 ABP1 / SRV2 Protein-peptide Landgraf C (2004)
SRV2 ABP1 / SRV2 Protein-peptide Rath A (2000)
SRV2 SRV2 / ABP1 Reconstituted Complex Freeman NL (1996)
SRV2 ABP1 / SRV2 Reconstituted Complex Lila T (1997)
SRV2 ABP1 / SRV2 Two-hybrid Drees BL (2001)
SRV2 ABP1 / SRV2 Two-hybrid Tong AH (2002)
TUP1 ABP1 / TUP1 Affinity Capture-MS Ho Y (2002)
YSC84 ABP1 / YSC84 Affinity Capture-MS Ho Y (2002)

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Tian W, et al. (2008) "Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function." Genome Biol. 9 Suppl 1():S7. PMID:18613951
  2. [ + ] Galletta BJ, et al. (2008) "Distinct roles for Arp2/3 regulators in actin assembly and endocytosis." PLoS Biol. 6(1):e1. PMID:18177206
  3. [ + ] Haarer B, et al. (2007) "Modeling complex genetic interactions in a simple eukaryotic genome: actin displays a rich spectrum of complex haploinsufficiencies." Genes Dev. 21(2):148-159. PMID:17167106
  4. [ + ] Haynes J, et al. (2007) "The biologically relevant targets and binding affinity requirements for the function of the yeast actin-binding protein 1 Src-homology 3 domain vary with genetic context." Genetics. 176(1):193-208. PMID:17409071
  5. [ + ] Collins SR, et al. (2007) "Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae." Mol Cell Proteomics. 6(3):439-450. PMID:17200106
  6. [ + ] Stefan CJ, et al. (2005) "The phosphoinositide phosphatase Sjl2 is recruited to cortical actin patches in the control of vesicle formation and fission during endocytosis." Mol Cell Biol. 25(8):2910-2923. PMID:15798181
  7. [ + ] D'Agostino JL, et al. (2005) "Dissection of Arp2/3 complex actin nucleation mechanism and distinct roles for its nucleation-promoting factors in Saccharomyces cerevisiae." Genetics. 171(1):35-47. PMID:16183906
  8. [ + ] Newpher TM, et al. (2005) "In vivo dynamics of clathrin and its adaptor-dependent recruitment to the actin-based endocytic machinery in yeast." Dev Cell. 9(1):87-98. PMID:15992543
  9. [ + ] Quintero-Monzon O, et al. (2005) "Structural and functional dissection of the Abp1 ADFH actin-binding domain reveals versatile in vivo adapter functions." Mol Biol Cell. 16(7):3128-3139. PMID:15872087
  10. [ + ] Germann M, et al. (2005) "Characterizing the sphingolipid signaling pathway that remediates defects associated with loss of the yeast amphiphysin-like orthologs, Rvs161p and Rvs167p." J Biol Chem. 280(6):4270-4278. PMID:15561700
  11. [ + ] Huckaba TM, et al. (2004) "Live cell imaging of the assembly, disassembly, and actin cable-dependent movement of endosomes and actin patches in the budding yeast, Saccharomyces cerevisiae." J Cell Biol. 167(3):519-530. PMID:15534003
  12. [ + ] Landgraf C, et al. (2004) "Protein interaction networks by proteome peptide scanning." PLoS Biol. 2(1):E14. PMID:14737190
  13. [ + ] Balcer HI, et al. (2003) "Coordinated regulation of actin filament turnover by a high-molecular-weight Srv2/CAP complex, cofilin, profilin, and Aip1." Curr Biol. 13(24):2159-2169. PMID:14680631
  14. [ + ] Zarrinpar A, et al. (2003) "Optimization of specificity in a cellular protein interaction network by negative selection." Nature. 426(6967):676-680. PMID:14668868
  15. [ + ] Ho Y, et al. (2002) "Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry." Nature. 415(6868):180-183. PMID:11805837
  16. [ + ] Fazi B, et al. (2002) "Unusual binding properties of the SH3 domain of the yeast actin-binding protein Abp1: structural and functional analysis." J Biol Chem. 277(7):5290-5298. PMID:11668184
  17. [ + ] Tong AH, et al. (2002) "A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules." Science. 295(5553):321-324. PMID:11743162
  18. [ + ] Kumar A, et al. (2002) "Subcellular localization of the yeast proteome." Genes Dev. 16(6):707-719. PMID:11914276
  19. [ + ] Warren DT, et al. (2002) "Sla1p couples the yeast endocytic machinery to proteins regulating actin dynamics." J Cell Sci. 115(Pt 8):1703-1715. PMID:11950888
  20. [ + ] Henry KR, et al. (2002) "Scd5p and clathrin function are important for cortical actin organization, endocytosis, and localization of sla2p in yeast." Mol Biol Cell. 13(8):2607-2625. PMID:12181333
  21. [ + ] Drees BL, et al. (2001) "A protein interaction map for cell polarity development." J Cell Biol. 154(3):549-571. PMID:11489916
  22. [ + ] Goode BL, et al. (2001) "Activation of the Arp2/3 complex by the actin filament binding protein Abp1p." J Cell Biol. 153(3):627-634. PMID:11331312
  23. [ + ] Rath A, et al. (2000) "The design of a hyperstable mutant of the Abp1p SH3 domain by sequence alignment analysis." Protein Sci. 9(12):2457-2469. PMID:11206067
  24. [ + ] Mintzer KA, et al. (1999) "The SH3 domain of the S. cerevisiae Cdc25p binds adenylyl cyclase and facilitates Ras regulation of cAMP signalling." Cell Signal. 11(2):127-135. PMID:10048790
  25. [ + ] Colwill K, et al. (1999) "In vivo analysis of the domains of yeast Rvs167p suggests Rvs167p function is mediated through multiple protein interactions." Genetics. 152(3):881-893. PMID:10388809
  26. [ + ] Cope MJ, et al. (1999) "Novel protein kinases Ark1p and Prk1p associate with and regulate the cortical actin cytoskeleton in budding yeast." J Cell Biol. 144(6):1203-1218. PMID:10087264
  27. [ + ] Wesp A, et al. (1997) "End4p/Sla2p interacts with actin-associated proteins for endocytosis in Saccharomyces cerevisiae." Mol Biol Cell. 8(11):2291-2306. PMID:9362070
  28. [ + ] Lila T, et al. (1997) "Evidence for physical and functional interactions among two Saccharomyces cerevisiae SH3 domain proteins, an adenylyl cyclase-associated protein and the actin cytoskeleton." Mol Biol Cell. 8(2):367-385. PMID:9190214
  29. [ + ] Goffeau A, et al. (1996) "Life with 6000 genes." Science. 274(5287):546, 563-546, 567. PMID:8849441
  30. [ + ] Freeman NL, et al. (1996) "A conserved proline-rich region of the Saccharomyces cerevisiae cyclase-associated protein binds SH3 domains and modulates cytoskeletal localization." Mol Cell Biol. 16(2):548-556. PMID:8552082
  31. [ + ] Holtzman DA, et al. (1994) "Mapping actin surfaces required for functional interactions in vivo." J Cell Biol. 126(2):423-432. PMID:8034743
  32. [ + ] Holtzman DA, et al. (1993) "Synthetic-lethal interactions identify two novel genes, SLA1 and SLA2, that control membrane cytoskeleton assembly in Saccharomyces cerevisiae." J Cell Biol. 122(3):635-644. PMID:8335689
  33. [ + ] Adams AE, et al. (1993) "Unexpected combinations of null mutations in genes encoding the actin cytoskeleton are lethal in yeast." Mol Biol Cell. 4(5):459-468. PMID:8334302
  34. [ + ] Oliver SG, et al. (1992) "The complete DNA sequence of yeast chromosome III." Nature. 357(6373):38-46. PMID:1574125
  35. [ + ] Drubin DG, et al. (1990) "Homology of a yeast actin-binding protein to signal transduction proteins and myosin-I." Nature. 343(6255):288-290. PMID:2405279
  36. [ + ] Drubin DG, et al. (1988) "Yeast actin-binding proteins: evidence for a role in morphogenesis." J Cell Biol. 107(6 Pt 2):2551-2561. PMID:3060468