Abcb11 | GeneID:83569 | Rattus norvegicus

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 83569 Official Symbol Abcb11
Locus N/A Gene Type protein-coding
Synonyms Bsep; Spgp
Full Name ATP-binding cassette, sub-family B (MDR/TAP), member 11
Description ATP-binding cassette, sub-family B (MDR/TAP), member 11
Chromosome N/A
Also Known As bile salt export pump; sister of P-glycoprotein
Summary acts as an ATP-dependent bile salt export pump; transports taurochenodeoxycholate, taurocholate, and other bile salts [RGD]

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0045177 Component apical part of cell
GO:0016324 Component apical plasma membrane
GO:0005794 Component Golgi apparatus
GO:0000139 Component Golgi membrane
GO:0016021 Component integral to membrane
GO:0046581 Component intercellular canaliculus
GO:0016020 Component membrane
GO:0005624 Component membrane fraction
GO:0005886 Component plasma membrane
GO:0016887 Function ATPase activity
GO:0042626 Function ATPase activity, coupled to transmembrane movement of substances
GO:0005524 Function ATP binding
GO:0015126 Function canalicular bile acid transmembrane transporter activity
GO:0015238 Function drug transporter activity
GO:0000166 Function nucleotide binding
GO:0005515 Function protein binding
GO:0015722 Process canalicular bile acid transport
GO:0046618 Process drug export
GO:0042493 Process response to drug
GO:0043627 Process response to estrogen stimulus
GO:0006979 Process response to oxidative stress
GO:0006810 Process transport

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_031760  UCSC Browser NP_113948
2 XM_579531  UCSC Browser XP_579531

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Transcript Cluster

[ - ] NCBI's UniGene

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Hayashi H, et al. (2009) "Short-chain ubiquitination is associated with the degradation rate of a cell-surface-resident bile salt export pump (BSEP/ABCB11)." Mol Pharmacol. 75(1):143-150. PMID:18829893
  2. [ + ] Yska MJ, et al. (2008) "The role of bile salt toxicity in the pathogenesis of bile duct injury after non-heart-beating porcine liver transplantation." Transplantation. 85(11):1625-1631. PMID:18551070
  3. [ + ] Kagawa T, et al. (2008) "Phenotypic differences in PFIC2 and BRIC2 correlate with protein stability of mutant Bsep and impaired taurocholate secretion in MDCK II cells." Am J Physiol Gastrointest Liver Physiol. 294(1):G58-G67. PMID:17947449
  4. [ + ] Fouassier L, et al. (2007) "Hypoxia-induced changes in the expression of rat hepatobiliary transporter genes." Am J Physiol Gastrointest Liver Physiol. 293(1):G25-G35. PMID:17615179
  5. [ + ] Zinchuk V, et al. (2007) "Ethanol consumption alters expression and colocalization of bile salt export pump and multidrug resistance protein 2 in the rat." Histochem Cell Biol. 127(5):503-512. PMID:17384956
  6. [ + ] Mochizuki K, et al. (2007) "Two N-linked glycans are required to maintain the transport activity of the bile salt export pump (ABCB11) in MDCK II cells." Am J Physiol Gastrointest Liver Physiol. 292(3):G818-G828. PMID:17082223
  7. [ + ] Donner MG, et al. (2007) "Obstructive cholestasis induces TNF-alpha- and IL-1 -mediated periportal downregulation of Bsep and zonal regulation of Ntcp, Oatp1a4, and Oatp1b2." Am J Physiol Gastrointest Liver Physiol. 293(6):G1134-G1146. PMID:17916651
  8. [ + ] Lam P, et al. (2007) "Levels of plasma membrane expression in progressive and benign mutations of the bile salt export pump (Bsep/Abcb11) correlate with severity of cholestatic diseases." Am J Physiol Cell Physiol. 293(5):C1709-C1716. PMID:17855769
  9. [ + ] Perez LM, et al. (2006) "Oxidative stress induces internalization of the bile salt export pump, Bsep, and bile salt secretory failure in isolated rat hepatocyte couplets: a role for protein kinase C and prevention by protein kinase A." Toxicol Sci. 91(1):150-158. PMID:16452108
  10. [ + ] Hirano M, et al. (2005) "Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin." J Pharmacol Exp Ther. 314(2):876-882. PMID:15901796
  11. [ + ] Crocenzi FA, et al. (2005) "Silibinin prevents cholestasis-associated retrieval of the bile salt export pump, Bsep, in isolated rat hepatocyte couplets: possible involvement of cAMP." Biochem Pharmacol. 69(7):1113-1120. PMID:15763547
  12. [ + ] Kubitz R, et al. (2004) "Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP kinase." Gastroenterology. 126(2):541-553. PMID:14762791
  13. [ + ] Ortiz DF, et al. (2004) "Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells." J Biol Chem. 279(31):32761-32770. PMID:15159385
  14. [ + ] Crocenzi FA, et al. (2003) "Estradiol-17beta-D-glucuronide induces endocytic internalization of Bsep in rats." Am J Physiol Gastrointest Liver Physiol. 285(2):G449-G459. PMID:12702498
  15. [ + ] Tomer G, et al. (2003) "Differential developmental regulation of rat liver canalicular membrane transporters Bsep and Mrp2." Pediatr Res. 53(2):288-294. PMID:12538788
  16. [ + ] Gerloff T, et al. (2002) "Functional analysis of the rat bile salt export pump gene promoter." Eur J Biochem. 269(14):3495-3503. PMID:12135489
  17. [ + ] Wang L, et al. (2002) "The role of bile salt export pump mutations in progressive familial intrahepatic cholestasis type II." J Clin Invest. 110(7):965-972. PMID:12370274
  18. [ + ] Tygstrup N, et al. (2002) "Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models." Biochem Biophys Res Commun. 290(1):518-525. PMID:11779202
  19. [ + ] Kipp H, et al. (2000) "Newly synthesized canalicular ABC transporters are directly targeted from the Golgi to the hepatocyte apical domain in rat liver." J Biol Chem. 275(21):15917-15925. PMID:10748167
  20. [ + ] Gerloff T, et al. (1998) "The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver." J Biol Chem. 273(16):10046-10050. PMID:9545351