FN3K | GeneID:64122 | Homo sapiens

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 64122 Official Symbol FN3K
Locus N/A Gene Type protein-coding
Synonyms
Full Name fructosamine 3 kinase
Description fructosamine 3 kinase
Chromosome 17q25.3
Also Known As fructosamine-3-kinase
Summary FN3K catalyzes phosphorylation of fructosamines formed by glycation, the nonenzymatic reaction of glucose with primary amines followed by Amadori rearrangement. Phosphorylation of fructosamines may initiate metabolism of the modified amine and result in deglycation of glycated proteins (Delpierre et al., 2000 [PubMed 11016445]).[supplied by OMIM]

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 23336

ID Symbol Protein Species
GeneID:63828 Fn3k NP_071297.1 Mus musculus
GeneID:64122 FN3K NP_071441.1 Homo sapiens
GeneID:417335 FN3K XP_415601.1 Gallus gallus
GeneID:498034 Fn3k XP_573235.1 Rattus norvegicus
GeneID:539709 FN3K NP_001069650.1 Bos taurus
GeneID:608337 FN3K XP_850422.1 Canis lupus familiaris

Antibodies

[ - ] Monoclonal and Polyclonal Antibodies

No. Provider Product No. Description
1 abcam ab71718 FN3K antibody - C-terminal (ab71718); Rabbit polyclonal to FN3K - C-terminal
2 abgent AP7083b FN3K Antibody (C-term); Purified Rabbit Polyclonal Antibody (Pab)
3 abgent AP7083a FN3K Antibody (N-term); Purified Rabbit Polyclonal Antibody (Pab)
4 abnova H00064122-M01 FN3K monoclonal antibody (M01), clone 4F2; Mouse monoclonal antibody raised against a partial recombinant FN3K.
5 acris AP13665PU-N FN3K (C-term); antibody Ab
6 acris AP13664PU-N FN3K (N-term); antibody Ab
7 scbt FN3K FN3K Antibody / FN3K Antibodies;

Exon, Intron and UTRs

Exon, Intron and UTRs of FN3K Gene Transcript Isoforms

CpG near TSS

CpG dinucleotides near Transcription Start Site of FN3K Gene

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005575 Component cellular_component
GO:0030387 Function fructosamine-3-kinase activity
GO:0016740 Function transferase activity
GO:0030393 Process fructoselysine metabolic process

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_022158  UCSC Browser NP_071441

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Mutations and SNPs

[ - ] NCBI's dbSNP

Phenotypes

[ - ] Genes and Diseases - MIM at NCBI

Chemicals and Drugs

[ - ] Comparative Toxicogenomics Database from MDI Biological Lab

Curated [chemical–gene interactions|chemical–disease|gene–disease] data were retrieved from the Comparative Toxicogenomics Database (CTD), Mount Desert Island Biological Laboratory, Salisbury Cove, Maine. World Wide Web (URL: http://ctd.mdibl.org/). [Jan. 2009].
Chemical and Interaction
Acetaminophen
  • Acetaminophen affects the expression of FN3K mRNA
17562736

Gene and Diseases

[ - ] Gene and Diseases [Data source: CTD]

Curated [chemical–gene interactions|chemical–disease|gene–disease] data were retrieved from the Comparative Toxicogenomics Database (CTD), Mount Desert Island Biological Laboratory, Salisbury Cove, Maine. World Wide Web (URL: http://ctd.mdibl.org/). [Jan. 2009].
Disease Name Relationship PubMed
Hepatitis, Toxic inferred via Acetaminophen 2444490, 17562736, 14986274, 17522070, 16081117, 16177239, 15968718, 16227642
Hyperalgesia inferred via Acetaminophen 16870215
Liver Failure, Acute inferred via Acetaminophen 16871587, 17185352
Pain inferred via Acetaminophen 16870215

Transcript Cluster

[ - ] NCBI's UniGene

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Szwergold BS, et al. (2007) "Fructosamine-6-phosphates are deglycated by phosphorylation to fructosamine-3,6-bisphosphates catalyzed by fructosamine-3-kinase (FN3K) and/or fructosamine-3-kinase-related-protein (FN3KRP)." Med Hypotheses. 68(1):37-45. PMID:16920277
  2. [ + ] Delpierre G, et al. (2006) "Variability in erythrocyte fructosamine 3-kinase activity in humans correlates with polymorphisms in the FN3K gene and impacts on haemoglobin glycation at specific sites." Diabetes Metab. 32(1):31-39. PMID:16523184
  3. [ + ] Conner JR, et al. (2005) "Some clues as to the regulation, expression, function, and distribution of fructosamine-3-kinase and fructosamine-3-kinase-related protein." Ann N Y Acad Sci. 1043():824-836. PMID:16037310
  4. [ + ] Delpierrre G, et al. (2004) "Identification of fructosamine residues deglycated by fructosamine-3-kinase in human hemoglobin." J Biol Chem. 279(26):27613-27620. PMID:15102834
  5. [ + ] Ota T, et al. (2004) "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat Genet. 36(1):40-45. PMID:14702039
  6. [ + ] Delplanque J, et al. (2004) "Tissue distribution and evolution of fructosamine 3-kinase and fructosamine 3-kinase-related protein." J Biol Chem. 279(45):46606-46613. PMID:15331600
  7. [ + ] Conner JR, et al. (2004) "The expression of the genes for fructosamine-3-kinase and fructosamine-3-kinase-related protein appears to be constitutive and unaffected by environmental signals." Biochem Biophys Res Commun. 323(3):932-936. PMID:15381090
  8. [ + ] Gerhard DS, et al. (2004) "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14(10B):2121-2127. PMID:15489334
  9. [ + ] Delpierre G, et al. (2003) "Fructosamine 3-kinase, an enzyme involved in protein deglycation." Biochem Soc Trans. 31(Pt 6):1354-1357. PMID:14641062
  10. [ + ] Delpierre G, et al. (2002) "Fructosamine 3-kinase is involved in an intracellular deglycation pathway in human erythrocytes." Biochem J. 365(Pt 3):801-808. PMID:11975663
  11. [ + ] Strausberg RL, et al. (2002) "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." Proc Natl Acad Sci U S A. 99(26):16899-16903. PMID:12477932
  12. [ + ] Szwergold BS, et al. (2001) "Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo." Diabetes. 50(9):2139-2147. PMID:11522682
  13. [ + ] Delpierre G, et al. (2000) "Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase." Diabetes. 49(10):1627-1634. PMID:11016445