Acan | GeneID:58968 | Rattus norvegicus

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 58968 Official Symbol Acan
Locus N/A Gene Type protein-coding
Synonyms Agc; Agc1
Full Name aggrecan
Description aggrecan
Chromosome 1q31
Also Known As aggrecan 1; aggrecan, structural proteoglycan of cartilage
Summary an extracellular matrix proteoglycan; cleaved by ADAMTS1 [RGD]

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 7227

ID Symbol Protein Species
GeneID:11595 Acan NP_031450.2 Mus musculus
GeneID:58968 Acan NP_071526.1 Rattus norvegicus
GeneID:280985 ACAN NP_776406.1 Bos taurus
GeneID:395798 ACAN XP_001232950.1 Gallus gallus
GeneID:403828 ACAN XP_536187.1 Canis lupus familiaris
GeneID:497505 agc1 XP_686182.3 Danio rerio
GeneID:559593 LOC559593 XP_688042.3 Danio rerio


[ - ] Monoclonal and Polyclonal Antibodies

No. Provider Product No. Description
1 abcam ab53731 Aggrecan antibody - Cleaved Asp369 (ab53731); Rabbit polyclonal to Aggrecan - Cleaved Asp369
2 abcam ab36861 Aggrecan antibody (ab36861); Rabbit polyclonal to Aggrecan
3 abcam ab3776 Aggrecan FFGxx antibody [BC-14] (ab3776); Mouse monoclonal [BC-14] to Aggrecan FFGxx
4 abcam ab3777 Aggrecan xxPEN antibody [BC-4] (ab3777); Mouse monoclonal [BC-4] to Aggrecan xxPEN
5 abcam ab16320 Aggrecan antibody (ab16320); Rabbit polyclonal to Aggrecan
6 abcam ab3773 Aggrecan ARGxx antibody [BC-3] (ab3773); Mouse monoclonal [BC-3] to Aggrecan ARGxx
7 sigma C8035 Monoclonal Anti-Chondroitin Sulfate antibody produced in mouse ;

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005604 Component basement membrane
GO:0031012 Component extracellular matrix
GO:0005576 Component extracellular region
GO:0005615 Component extracellular space
GO:0005578 Component proteinaceous extracellular matrix
GO:0005201 Function extracellular matrix structural constituent
GO:0005540 Function hyaluronic acid binding
GO:0005515 Function protein binding
GO:0005529 Function sugar binding
GO:0001502 Process cartilage condensation
GO:0007155 Process cell adhesion
GO:0007417 Process central nervous system development
GO:0002063 Process chondrocyte development
GO:0030199 Process collagen fibril organization
GO:0030166 Process proteoglycan biosynthetic process

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_022190  UCSC Browser NP_071526

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

J03485   M13518   NM_022190  

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Transcript Cluster

[ - ] NCBI's UniGene

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Cancel M, et al. (2009) "Effects of in vivo static compressive loading on aggrecan and type II and X collagens in the rat growth plate extracellular matrix." Bone. 44(2):306-315. PMID:18849019
  2. [ + ] Agrawal A, et al. (2007) "Normoxic stabilization of HIF-1alpha drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk." Am J Physiol Cell Physiol. 293(2):C621-C631. PMID:17442734
  3. [ + ] Carulli D, et al. (2007) "Upregulation of aggrecan, link protein 1, and hyaluronan synthases during formation of perineuronal nets in the rat cerebellum." J Comp Neurol. 501(1):83-94. PMID:17206619
  4. [ + ] Popp S, et al. (2003) "Localization of aggrecan and versican in the developing rat central nervous system." Dev Dyn. 227(1):143-149. PMID:12701107
  5. [ + ] Matthews RT, et al. (2002) "Aggrecan glycoforms contribute to the molecular heterogeneity of perineuronal nets." J Neurosci. 22(17):7536-7547. PMID:12196577
  6. [ + ] Doege K, et al. (2002) "A remote upstream element regulates tissue-specific expression of the rat aggrecan gene." J Biol Chem. 277(16):13989-13997. PMID:11834732
  7. [ + ] Rodriguez-Manzaneque JC, et al. (2002) "ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors." Biochem Biophys Res Commun. 293(1):501-508. PMID:12054629
  8. [ + ] Neame PJ, et al. (1987) "Cartilage proteoglycan aggregates. The link protein and proteoglycan amino-terminal globular domains have similar structures." J Biol Chem. 262(36):17768-17778. PMID:3693371
  9. [ + ] Doege K, et al. (1987) "Complete primary structure of the rat cartilage proteoglycan core protein deduced from cDNA clones." J Biol Chem. 262(36):17757-17767. PMID:3693370
  10. [ + ] Doege K, et al. (1986) "Partial cDNA sequence encoding a globular domain at the C terminus of the rat cartilage proteoglycan." J Biol Chem. 261(18):8108-8111. PMID:2424893